Trials / Unknown
UnknownNCT05726513
Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- Università degli Studi di Ferrara · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical ventilation for acute respiratory failure. The main question\[s\] it aims to answer are: * to evaluate which weaning trial is associated to a better regional ventilation distribution * to evaluate which weaning trial can be comparable to ventilation distribution after extubation Participants will undergo 3 clinically used weaning trials in a random order (cross-over trial). Researchers will compare the different steps to see if regional ventilation distribution is different among the different trial .
Conditions
- Acute Respiratory Failure
- Mechanical Ventilation Complication
- Ventilator-Induced Lung Injury
- Weaning Failure
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Weaning trial - Low support, high Positive end-expiratory pressure | The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with low pressure support ventilation and a positive end expiratory pressure of 5 cmH2O |
| DIAGNOSTIC_TEST | Weaning trial - Low support, zero positive end-expiratory pressure | The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with low pressure support ventilation and a positive end expiratory pressure of 0 cmH2O |
| DIAGNOSTIC_TEST | Weaning trial - Zero support, zero positive end-expiratory pressure | The researcher will evaluate the readiness to be weaned of the patient using a weaning trial with 0 pressure support ventilation and a positive end expiratory pressure of 0 cmH2O |
Timeline
- Start date
- 2023-02-15
- Primary completion
- 2024-05-30
- Completion
- 2024-12-31
- First posted
- 2023-02-14
- Last updated
- 2023-02-14
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT05726513. Inclusion in this directory is not an endorsement.