NCT03406936

Sedation and Ease of Weaning From Mechanical Ventilation

Daily Interruption of Sedation Versus Non Sedation in Mechanically Ventilated Respiratory Failure Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.

Detailed description

there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .

Conditions

• Respiratory Failure
• Midazolam Overdose
• Chronic Obstructive Pulmonary Disease
• Weaning Failure

Interventions

Type	Name	Description
DRUG	Daily interruption of midazolam	daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done

Timeline

• Start date: 2016-08-20
• Primary completion: 2017-06-28
• Completion: 2017-10-30
• First posted: 2018-01-23
• Last updated: 2018-01-23

Locations

1 site across 1 country: Egypt