| Not Yet Recruiting | Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) NCT07145866 | Massachusetts General Hospital | Phase 4 |
| Withdrawn | Persistence of Oral DNA Adducts in Smokers and Vapers NCT06983392 | University of Minnesota | N/A |
| Not Yet Recruiting | Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues NCT07348224 | Insel Gruppe AG, University Hospital Bern | N/A |
| Recruiting | The Use of tDCS for Vaping Reduction NCT06885606 | Centre for Addiction and Mental Health | N/A |
| Not Yet Recruiting | A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth D NCT07162155 | Christopher Williams | N/A |
| Enrolling By Invitation | A Virtual Reality Vaping Prevention Intervention for Adolescents NCT07362069 | Yale University | — |
| Recruiting | A Trial of Varenicline for E-cigarette Cessation NCT07040566 | Yale University | Phase 2 |
| Recruiting | Perceived Effectiveness of Vaping Prevention Ads Among Adolescents and Young Adults NCT07116837 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Completed | A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping NCT07413432 | Yale University | N/A |
| Recruiting | Vape Use Among Younger & Older Smokers NCT07214168 | Abramson Cancer Center at Penn Medicine | — |
| Enrolling By Invitation | Understanding Vape Marketing Study NCT07129265 | Boston Children's Hospital | — |
| Recruiting | The Canadian Lung Outcomes in Users of Vaping Devices Study NCT06819969 | University of British Columbia | — |
| Completed | Influencer Marketing and Adolescent E-cigarette Use NCT07420842 | University of Southern California | N/A |
| Recruiting | Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration NCT05999383 | University of California, San Francisco | Phase 2 |
| Recruiting | Behavioral Intervention for Youth to Promote Vaping Cessation NCT06765291 | Massachusetts General Hospital | N/A |
| Recruiting | Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study NCT06804109 | Temple University | N/A |
| Enrolling By Invitation | Nicotine and Cannabis Vape Labeling Experiment - Spring 2025 NCT06919276 | University of Southern California | N/A |
| Completed | Human Factors Validation and Usability Testing of the IKE Age-Gating System NCT06952569 | IKE Tech | — |
| Completed | Responses to E-cigarette Message Source and Presentation NCT06274723 | University of Massachusetts, Worcester | N/A |
| Completed | Point-of-Care Ultrasound (POCUS) Findings and Impact on Vaping NCT06335329 | Medical University of South Carolina | N/A |
| Active Not Recruiting | Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users NCT06164678 | Ottawa Heart Institute Research Corporation | N/A |
| Completed | Social Media Vaping Cessation Pilot With Peer Mentors NCT07437196 | University of California, San Francisco | N/A |
| Completed | Vaping Prevention and Vaping in Youth (Vapechat) NCT06003439 | Boston University | N/A |
| Completed | Social Media Anti-Vaping Messages to Reduce ENDS Use Among Sexual and Gender Minority Teens NCT06308081 | Abramson Cancer Center at Penn Medicine | N/A |
| Completed | Responses to Message Source and Presentation Using Psychophysiology NCT06269003 | University of Massachusetts, Worcester | N/A |
| Completed | Influencer Marketing: a Survey-based Experiment Among Adolescents NCT06501937 | University of Southern California | N/A |
| Recruiting | Concentration Impact Nicotine Salt NCT04725656 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults NCT05897242 | Fred Hutchinson Cancer Center | N/A |
| Recruiting | The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes Study NCT06297005 | University College Dublin | — |
| Recruiting | Implementing an Adolescent and Young Adult (AYA) mHealth Vaping Cessation Program Into Oncology Clinics NCT05967585 | St. Jude Children's Research Hospital | N/A |
| Unknown | Investigating Exposure to Toxicants From Smoking and Vaping NCT05953220 | King's College London | — |
| Completed | Adolescent Inpatient Tobacco and ENDS Intervention NCT05936099 | Children's Mercy Hospital Kansas City | N/A |
| Active Not Recruiting | Perioperative Vaping Complications NCT05912023 | Navy Medical Center San Diego | — |
| Completed | Influencer Marketing: a Survey-based Experiment NCT06433466 | University of Southern California | N/A |
| Completed | A Brief Digital Screening Tool to Address Tobacco and E-cigarette Use in Pediatric Medical Care NCT05366790 | St. Justine's Hospital | N/A |
| Withdrawn | Feasibility of Treatment for Vaping Cessation NCT04317300 | Mayo Clinic | EARLY_Phase 1 |
| Completed | Vaper to Vaper: A Multimodal Mobile Peer Driven Intervention to Support Adolescents in Quitting Vaping NCT05140915 | University of Massachusetts, Worcester | N/A |
| Withdrawn | Characterization of the Pharmacodynamic Response to Vaped THC NCT04340700 | Massachusetts General Hospital | Phase 3 |
| Active Not Recruiting | Testing a School-Based E-cigarette, Tobacco, and Betel (Areca) Nut Use Prevention Curriculum for Guam Youths NCT05037656 | University of Guam | N/A |
| Recruiting | Early Detection of Vaping-related Vascular Diseases NCT05454267 | University of Miami | — |
| Completed | Reduced HPHC Exposure in Cigarette Smokers Switching to P4M3 Gen. 2.0 Compared to Continuing Smoking, or Smoki NCT05487456 | Philip Morris Products S.A. | N/A |
| Completed | A Study of Cytisinicline for Vaping Cessation in Adult Smokers NCT05431387 | Achieve Life Sciences | Phase 2 |
| Completed | Varenicline for Nicotine Vaping Cessation in Adolescents NCT05367492 | Massachusetts General Hospital | Phase 4 |
| Completed | Nicotine Pharmacokinetics Following Use of the P4M3 Gen 2.0 E-Cigarette Compared to Smoking Cigarettes NCT05383508 | Philip Morris Products S.A. | N/A |
| Unknown | Smoking Prevention Program in Poland NCT05488743 | Wroclaw Medical University | — |
| Completed | The e-BILD Study: Effects of E-cigarettes on Lung Health in Teenagers. NCT05105555 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | Cessation of Smoking Trial in the Emergency Department NCT04854616 | Norfolk and Norwich University Hospitals NHS Foundation Trust | N/A |
| Completed | Social Media Intervention to Stop Nicotine and Cannabis Vaping Among Adolescents NCT04707911 | University of California, San Francisco | N/A |
| Recruiting | Vaping Adverse Lung and Heart Events Cohort NCT06291597 | Laval University | — |
| Completed | Text Message Quit Vaping Intervention for Adolescents NCT04919590 | Truth Initiative | N/A |
| Completed | Graphic Messages to Prevent E-Cigarette Use Among Black and Latino Adolescents NCT04899999 | University of Rochester | N/A |
| Completed | Impact of Vaping Prevention Advertisements NCT04836455 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Recruiting | Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol NCT04661683 | University of California, Los Angeles | N/A |
| Completed | Menthol and Mint Experimental Tobacco Marketplace (ETM) Study NCT04879225 | Wake Forest University Health Sciences | N/A |
| Terminated | Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents NCT04602494 | Massachusetts General Hospital | Phase 4 |
| Completed | Acute Effects of TCIG vs ECIG in PLWH NCT04568395 | University of California, Los Angeles | N/A |
| Active Not Recruiting | Network Intervention to Prevent Vaping NCT04678245 | University of Rochester | N/A |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1 NCT05958979 | University of Southern California | N/A |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2 NCT05958992 | University of Southern California | N/A |
| Unknown | Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation NCT04645914 | University Hospital Muenster | N/A |
| Completed | PACE Vape Messaging Study NCT04450537 | University of Vermont | N/A |
| Completed | Acute Effects of Vaping Nicotine on Cognition in Young Adults NCT04901208 | Yale University | N/A |
| Terminated | To Vape or Not to Vape NCT05240027 | Methodist Health System | N/A |
| Completed | Assessment of Smoking, Vaping, and Alcohol Consumption Behavior NCT04150510 | Pennington Biomedical Research Center | — |
| Completed | Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes NCT04053868 | University of California, San Francisco | N/A |
| Completed | Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1 NCT04399031 | University of Southern California | N/A |
| Completed | A Virtual Reality Videogame for E-cigarette Prevention in Teens NCT04054765 | Yale University | N/A |
| Completed | Modeling Stress-precipitated Vaping Behavior NCT04522362 | Clemson University | N/A |
| Completed | Study to Investigate the Nicotine Pharmacokinetic Profiles and Pharmacodynamic Effects of P4M3 Variants NCT03379740 | Philip Morris Products S.A. | N/A |