NCT04661683

Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol

Investigating the Secondhand Effects of Hookah Smoking and Vaping

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 21 Years – 49 Years
• Healthy volunteers: Accepted

Summary

In the United States, secondhand smoke is the third leading preventable cause of death. Flavored hookah (waterpipe) tobacco smoking, a highly social activity common in hookah bars, is a key source of SHS exposure. While smoke-free air laws have decreased exposure to secondhand smoke, the majority of laws do not include hookah smoking. Thus, as a social outlet for youth and young adults, hookah smoke exposure may harm non-smokers, including women of reproductive age or pregnant, hookah bar workers, children, and individuals with heart and lung disease. While more is known on the acute effects of active hookah smoking and the literature is emerging on active e-hookah vaping, little is known about the acute vascular effects of secondhand exposure to hookah smoke and aerosol. The study aims to examine the acute effects of secondhand exposure of hookah smoke and aerosol on endothelial and vascular function. Eligible volunteers will be invited to participate in a total of 3 study visits (2-3 hours each): e-hookah aerosol exposure, charcoal-heated hookah smoke exposure and smoke-free room air. Non-invasive blood pressure and blood flow measurements will be taken before and after the exposure sessions.

Conditions

• Hookah Smoking
• Secondhand Aerosol
• Vascular Stiffness
• Vaping

Interventions

Type	Name	Description
OTHER	Combustible Hookah Smoke	Exposure to combustible hookah smoke for a duration of 60 minutes.
OTHER	Electronic Hookah Aerosol	Exposure to electronic hookah aerosol for a duration of 60 minutes.
OTHER	Clean Room Air	Exposure to room air for a duration of 60 minutes.

Timeline

• Start date: 2021-06-25
• Primary completion: 2026-12-15
• Completion: 2027-04-15
• First posted: 2020-12-10
• Last updated: 2026-01-16

Locations

1 site across 1 country: United States