| Not Yet Recruiting | A Study Of Clinical Implications Of Pulmonary Vascular Disease In Valvular Heart Disease NCT07483203 | Mayo Clinic | — |
| Not Yet Recruiting | Cardiovascular Acoustics for Early Disease Detection NCT07496775 | Cambridge University Hospitals NHS Foundation Trust | — |
| Recruiting | DELINEATE-Prospective NCT07197736 | Columbia University | — |
| Not Yet Recruiting | Longitudinal Validation of CIRC Technologies NCT07081711 | The Cleveland Clinic | — |
| Not Yet Recruiting | Comparison of Post-operation Cardiopulmonary Capacity of Patients Underwent Conventional and Robot-assisted Co NCT05430568 | Taichung Veterans General Hospital | — |
| Recruiting | Optimized Expansion of the Implanted Transcatheter Aortic Valve NCT07042529 | Ole De Backer | N/A |
| Not Yet Recruiting | MULTIVALVE : A Prospective Multicentre Study of Multiple and Mixed Valvular Heart Disease NCT07176507 | French Cardiology Society | — |
| Recruiting | Mechanism and Effect of Novel Metabolites on Valvular Heart Disease NCT07065500 | Sun Yat-sen University | — |
| Recruiting | Comparing Measurements of the Aortic Valve Taken During Surgery With Those Obtained Before Surgery Using Compu NCT07125469 | Maria Cecilia Hospital | N/A |
| Recruiting | Evaluation of Valvular Heart Disease Using Cardiac CT NCT06937125 | Toho University | — |
| Recruiting | Screening of Valvular Heart Disease Using Single-channel Electrocardiogram NCT07099417 | I.M. Sechenov First Moscow State Medical University | — |
| Recruiting | AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor NCT06699056 | Peerbridge Health, Inc | — |
| Not Yet Recruiting | a Foundational Model for Cardiovascular Disease Diagnosis and Prediction NCT06591923 | Shanghai Zhongshan Hospital | — |
| Recruiting | Abbott Structural Heart Device Registry NCT06590467 | Abbott Medical Devices | — |
| Recruiting | Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4) NCT05996120 | University of Leicester | N/A |
| Recruiting | Detection of Valvular Heart Disease Using Artificial Intelligence-based Stethoscope NCT06386016 | Xiao-dong Zhuang | — |
| Recruiting | Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer Population NCT06634121 | LMU Klinikum | N/A |
| Recruiting | Home-Based Cardiac Rehabilitation Using a Novel Mobile Health Exercise Regimen Following Transcatheter Heart V NCT06077201 | Vanderbilt University Medical Center | N/A |
| Active Not Recruiting | Can a Smartphone Listen to Your Heart? A Performance Study on Detecting Abnormalities in Your Heart Sounds NCT06070298 | Wong Chun Ka | — |
| Unknown | Milrinone on Right Ventricular Strain in Cardiac Surgery NCT06077721 | Konkuk University Medical Center | — |
| Enrolling By Invitation | Reviving Early Diagnosis of Cardiovascular Disease in the Utrecht Health Project NCT05775354 | UMC Utrecht | N/A |
| Recruiting | European Registry of Transcatheter Repair for Tricuspid Regurgitation NCT06307262 | LMU Klinikum | — |
| Unknown | Short Term Outcomes Of Tricuspid Valve Annuloplasty Using A Flexible Band NCT05936125 | Assiut University | N/A |
| Unknown | Middle East African Registry Women CardioVascular Disease NCT05869214 | Tunisian Society of Cardiology and Cardiovascular Surgery | — |
| Completed | NHLBI Transmural Electrosurgery LeafLet Traversal And Laceration Evaluation (TELLTALE) BASILICA-TAVR Trial NCT05666713 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Unknown | Evaluation and Validation of Management Strategy for Conductive Disorders After TAVR (EVATAVI) NCT05417464 | University Hospital, Montpellier | N/A |
| Recruiting | Vibrometer Based Pulse Wave Analysis for Arterial Stiffness and Ischemic Heart Disease Risk Assessment NCT06984211 | HJN Sverige AB/Neko Health | — |
| Unknown | Progression of Ascending Aorta Diameters in Bicuspid Aortic Valve After Transcatheter or Surgical Replacement. NCT05708118 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | Real-time Pressure Volume Loop Monitoring as a Guide for Enhanced Understanding of Changes in Elemental Cardio NCT06204783 | Erasmus Medical Center | — |
| Completed | Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surge NCT05708690 | Indonesia University | Phase 4 |
| Recruiting | Development of CIRC Technologies NCT05654272 | The Cleveland Clinic | — |
| Completed | Evaluation of an Automated Smartphone-based Digital Auscultation Application for Detecting Abnormal Heart Soun NCT05325723 | University Hospital, Basel, Switzerland | — |
| Unknown | Reliability of Artificial Intelligence (AI)-Augmented Point-of-care Cardiac Ultrasound in the Hands of Interni NCT05455541 | Sheba Medical Center | — |
| Unknown | Valvular Heart Disease in Jiangxi Province NCT05523193 | Xiao Huang | — |
| Unknown | Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy NCT05892588 | Azienda Ospedaliero-Universitaria Careggi | — |
| Active Not Recruiting | Age and Sex-Specific PREValence of AcqUirEd VALVular Heart DiseasE NCT05357404 | Cardiovascular Research Foundation, New York | — |
| Completed | Hemodynamic Effect of Topical Anesthesia During Induction in Patients Undergoing Cardiac Surgery NCT05323786 | Qianfoshan Hospital | N/A |
| Recruiting | Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure NCT05573997 | Aristotle University Of Thessaloniki | — |
| Completed | Regent China Post-Market Clinical Follow-up Study NCT05330468 | Abbott Medical Devices | — |
| Completed | Sugammadex Titration in Cardiac Surgery Patients NCT05246397 | University of Washington | Phase 4 |
| Active Not Recruiting | Echocardiographic Screening of Pregnant Women During Antenatal Care NCT04936815 | Thomas Pilgrim | N/A |
| Unknown | Impact in Quality of Care of the "STructural heARt NURSE" as New Interventional Cardiology Nursing Role in Spa NCT04301648 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Active Not Recruiting | Percutaneous Coronary Intervention Before Transcatheter Aortic Valve Implantation NCT05078619 | UMC Utrecht | N/A |
| Unknown | Study on Standard Evaluation System and Optimal Treatment Path of Senile Valvular Heart Disease NCT05044338 | Yongjian Wu | — |
| Unknown | Frailty of Elderly With Valvular Heart Disease and the Short Term Adverse Events NCT05014750 | Shanghai Zhongshan Hospital | — |
| Recruiting | PPG to Predict Ejection Fraction and Other Echographic Data in the General Population NCT04843371 | Tulane University | — |
| Unknown | Pathological Changes in the Cardiovascular System in Valvular Heart Disease NCT06060171 | University College, London | — |
| Recruiting | Simultaneous Cardiac Surgery and Micronet-covered Stent Carotid Revascularization in High Perioperative Stroke NCT04973579 | John Paul II Hospital, Krakow | — |
| Unknown | Copeptin and HFABP in Cardiac Surgery NCT04877795 | Heinrich-Heine University, Duesseldorf | — |
| Recruiting | Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging NCT05081115 | Fatebenefratelli Hospital | — |
| Completed | Effect of Topical Anesthesia on Hemodynamics During the Induction Period in Patients Undergo Cardiac Surgery. NCT04744480 | Qianfoshan Hospital | N/A |
| Completed | Impact of a PROgram of Cardiovascular Nurse interventionS in a VALVular haEmodynamic Unit (PROCESS-VALVE) on Q NCT05179278 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Completed | Prehabilitation and Heart Valve Surgery NCT04993963 | Riphah International University | N/A |
| Recruiting | Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study NCT04761120 | Abbott Medical Devices | — |
| Recruiting | In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation NCT06675448 | Inova Health Care Services | — |
| Completed | The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass. NCT04833283 | I.M. Sechenov First Moscow State Medical University | N/A |
| Completed | Whole-task Hybrid Simulation Improves Medical Student Competence in Cardiology Clerkship NCT05895799 | Royal College of Surgeons, Ireland | N/A |
| Active Not Recruiting | The Relationship Between Inflammatory ARTritis and CArdiac DIseAse NCT05647577 | University Hospital, Gentofte, Copenhagen | — |
| Unknown | Effect of Trunk Stabilizing Exercises on Patients With Median Sternotomy After Heart Valve Surgery NCT04632914 | Cairo University | N/A |
| Completed | Effectiveness of Simulation-based Training on Transoesophageal Echocardiography Learning NCT05564507 | Groupe des jeunes de la filiale d'imagerie cardiovasculaire | N/A |
| Completed | Prognostic Value of Lung Ultrasound in Predicting Intensive Care Unit Length of Stay in Adult Cardiac Surgery NCT04499027 | Fayoum University Hospital | — |
| Completed | The PROTEMBO C Trial NCT04618718 | Protembis GmbH | N/A |
| Recruiting | SMART Watch Facilitated Early Discharge in Patients Undergoing Transcatheter Aortic Valve Replacement NCT04454177 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | National Tunisian Registry of Valvulopathies (NATURE-VALVE) NCT04509479 | Dacima Consulting | — |
| Completed | Efficacy of Sternum Guard in Post Cardiac Surgery Patient NCT05229276 | Indonesia University | N/A |
| Unknown | Diagnostic Impact of Low-dose Dobutamine Echocardiography in Low-flow Low-gradient Aortic Stenosis NCT05015829 | Odense University Hospital | — |
| Terminated | Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Moda NCT03935178 | Dartmouth-Hitchcock Medical Center | — |
| Completed | Canadian EdoxAban(Lixiana®) Registry in Patients With ATrial Fibrillation/Flutter With Confirmed ValvUlar HeaR NCT03488420 | Montreal Heart Institute | — |
| Completed | Validation Study of an Advanced Blood Pressure Monitor NCT04030494 | Withings | N/A |
| Completed | Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) NCT03541213 | University Hospital, Angers | N/A |
| Unknown | The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Und NCT04080219 | Yonsei University | — |
| Unknown | Multicenter Registry Study of Aortic Valve Stenosis in Zhejiang Elderly（Mrs AVS） NCT03797820 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Safety and Efficacy of the Gastric Reactance (XL) in Patients Post-operated of Elective Cardiac Surgery NCT03799133 | Critical Perfusion Inc. | N/A |
| Unknown | Pre-habilitation of Patients Scheduled for Cardiac Valve Surgery NCT03571906 | Sheba Medical Center | N/A |
| Withdrawn | PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients NCT03399162 | Ottawa Heart Institute Research Corporation | N/A |
| Unknown | Fluid Status and T1-mapping by CMR NCT03372512 | Medical University of Vienna | — |
| Completed | Development and Validation of Automated Indicators on the Appropriateness of Oral Anticoagulant Prescriptions NCT02898090 | University Hospital, Bordeaux | — |
| Completed | The China Valvular Heart Disease Study NCT03484806 | China National Center for Cardiovascular Diseases | — |
| Terminated | Improving Mitral Repair for Functional Mitral Regurgitation NCT03366649 | Emory University | N/A |
| Completed | Implementation of a Trimodal Prehabilitation Program as a Preoperative Optimization Strategy in Cardiac Surger NCT03466606 | Hospital Clinic of Barcelona | N/A |
| Completed | Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery NCT03280745 | Insel Gruppe AG, University Hospital Bern | Phase 4 |
| Completed | Phono- and Electrocardiogram Assisted Detection of Valvular Disease NCT03458806 | University of California, San Francisco | — |
| Unknown | Fluid Status in Valvular Heart Disease NCT03371394 | Medical University of Vienna | — |
| Terminated | Benefits of ICD for the Primary Prevention in Patients With Valvular Cardiomyopathy NCT03590730 | Keimyung University Dongsan Medical Center | — |
| Completed | Impact of Perioperative Shedding of the Endothelial Glycocalyx on the Incidence of Postoperative Acute Kidney NCT03197051 | Yonsei University | — |
| Recruiting | Valvular Heart Disease Registry Study in Second Affiliated Hospital of ZheJiang University NCT03011697 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Unknown | Transcatheter Para-Valvular Leak Closure: An International Prospective Multicentre Registry NCT05089136 | Centre Chirurgical Marie Lannelongue | — |
| Completed | Genotype-guided Versus Standard for Warfarin Dosing NCT03479684 | China National Center for Cardiovascular Diseases | N/A |
| Unknown | Strategies for Revascularization in Patients Undergoing Heart Valve Surgery With Concomitant Coronary Artery D NCT02173860 | Portuguese Society of Cardiology | N/A |
| Completed | Inflammatory Mediator Profiles During Heart Valve Replacement Surgery NCT02727413 | Jena University Hospital | — |
| Unknown | Impact of Positive End-expiratory Pressure on Hepatic Venous Flow NCT02700581 | Konkuk University Medical Center | N/A |
| Completed | RIvaroxaban for Valvular Heart diseasE and atRial Fibrillation Trial -RIVER Trial NCT02303795 | Hospital do Coracao | Phase 2 |
| Completed | The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulm NCT02479581 | Xiangya Hospital of Central South University | Phase 2 |
| Recruiting | Valvular Heart Disease Registry NCT03488732 | Technical University of Munich | — |
| Completed | Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart Surgery NCT02490644 | Yonsei University | — |
| Completed | Predicting Aortic Stenosis Progression by Measuring Serum Calcification Propensity NCT02241109 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery NCT02136979 | Konkuk University Medical Center | Phase 4 |
| Withdrawn | Prolongation of the Interval Between Prothrombin Time Tests in Stable Patients II NCT01654042 | McMaster University | Phase 3 |
| Unknown | Effect of Desflurane on Cardiac Function During Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annula NCT02003885 | Konkuk University Medical Center | N/A |
| Unknown | Application of Remote Ischemic Preconditioning in Patients Undergoing Open Heart Surgeries NCT01906918 | University of Campinas, Brazil | N/A |
| Completed | Propofol Effects on Mitral Valve Annular Velocity NCT01826149 | Konkuk University Medical Center | Phase 4 |
| Completed | Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery NCT01825720 | Yonsei University | N/A |
| Completed | Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery NCT01819012 | Konkuk University Medical Center | N/A |
| Completed | ADVANCE Direct Aortic Study NCT01676727 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Completed | Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent NCT01681095 | Marc Sakwa, MD | Phase 2 |
| Completed | The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot NCT01623193 | Pam Trenholm | N/A |
| Completed | The Cortisol Levels During Cardiac Surgery. The Comparison Between Etomidate and Thiopentone NCT01495949 | Mahidol University | Phase 4 |
| Completed | Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery NCT01477151 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 4 |
| Completed | CoreValve Advance-II Study: Prospective International Post-market Study NCT01624870 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Completed | Normothermia Versus Hypothermia for Valvular Surgery Patients NCT01338961 | Meshalkin Research Institute of Pathology of Circulation | N/A |
| Completed | Prognostic Indicators as Provided by the EPIC ClearView NCT01476995 | Epic Research & Diagnostics, Inc. | — |
| Unknown | Severe Aortic Stenosis in Patients Referred for Valve Surgery NCT01794832 | Oslo University Hospital | — |
| Completed | The Bronx-Valve Registry NCT05453526 | Montefiore Medical Center | — |
| Completed | Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery NCT01511991 | Konkuk University Medical Center | EARLY_Phase 1 |
| Completed | Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease NCT00862043 | Hospital General Universitario Gregorio Marañon | Phase 4 |
| Unknown | Vigileo FloTrac vs Pulmonary Artery Catheter NCT00641290 | Hospital Sultanah Aminah Johor Bahru | — |
| Completed | Comparison of Goal-directed Algorithms of Hemodynamic Therapy After Combined Valve Repair NCT01276444 | Northern State Medical University | N/A |
| Completed | Randomized Study of the Use of Warfarin During Pacemaker or ICD Implantation in Patients Requiring Long Term A NCT00721136 | Johns Hopkins University | N/A |
| Unknown | Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement NCT03163836 | Guangzhou General Hospital of Guangzhou Military Command | — |
| Completed | Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery NCT01174719 | Medical University of Vienna | Phase 4 |
| Completed | Epidemiology and Long-term Outcome of Patients With VHD NCT04527367 | Medical University of Bialystok | — |
| Terminated | MPAACS: Magnesium for the Prevention of Atrial Arrhythmias After Cardiac Surgery NCT00250965 | University of British Columbia | Phase 3 |
| Completed | Observational Study of Prosthetic Tissue Aortic and Mitral Heart Valve NCT00329667 | Abbott Medical Devices | N/A |