NCT01826149

Propofol Effects on Mitral Valve Annular Velocity

The Effect of Propofol on Tissue Doppler Imaging of Mitral Valve Annular Velocity During Remifentanil-based Cardiac Anesthesia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Konkuk University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is primarily to determine the effects of propofol at different concentration on the mitral valve annulus by using Tissue Doppler Imaging

Detailed description

The purpose of this study is to evaluate the effects of different concentration of propofol on patients who are undergoing cardiac surgery. The patients will receive infusion remifentanil 0.5mcg/kg/min with different target-site propofol concentration namely 1.0ng/ml, 2.0ng/ml and 3.0ng/ml. Tissue Doppler Imaging by transesophageal echocardiography will be done to assess the changes in cardiac function.

Conditions

• Valvular Heart Disease
• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	Propofol 1.0mcg	Propofol dosage titration to achieve effect site concnetration at 1.0 mcg/ml using target controlled infusion.
DRUG	Propofol 2.0mcg	Propofol dosage titration to achieve effect site concnetration at 2.0 mcg/ml using target controlled infusion.
DRUG	Propofol 3.0mcg	Propofol dosage titration to achieve effect site concnetration at 3.0 mcg/ml using target controlled infusion

Timeline

• Start date: 2013-04-01
• Primary completion: 2015-12-01
• First posted: 2013-04-08
• Last updated: 2016-04-20

Locations

1 site across 1 country: South Korea