NCT01511991

Sevoflurane's Effect on Mitral Valve Annular Velocity in Cardiac Surgery

Sevoflurane's Effect on Tissue Doppler Profiles of Lateral Mitral Annulus During Cardiac Surgery

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Konkuk University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine sevoflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different sevoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE)in cardiac surgery patients.

Detailed description

Following data would be determined after 10 min-exposure to each dosage of sevoflurane with 1.0, 2.0 and 3.0 inspired vol% (T1, T2 and T3, respectively) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=14): 1. TDI of lateral mitral annulus at systole (S'), early filling (E') and atrial contraction (A') 2. transmitral flow Doppler at early filling (E), atrial contraction (A), deceleration time; 3. LV-ejection fraction (EF) 4. bispectral index (BIS) 5. phenylephrine-infusion rate 6. other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (CVP), pulmonary capillary wedge pressure (PCWP), mixed venous O2 saturation (SvO2), cardiac index (CI) and stroke volume index (SVI)

Conditions

• Valvular Heart Disease

Interventions

Type	Name	Description
DRUG	Sevoflurane dosage titration	comparisons of the effect of the 10 min-inhalation of each concentration of sevoflurane, 1.0 inspired vol%, 2.0 inspired vol% and 3.0 inspired vol% (T1, T2 and T3)

Timeline

• Start date: 2009-05-01
• Primary completion: 2014-05-01
• Completion: 2014-05-01
• First posted: 2012-01-19
• Last updated: 2015-02-24

Locations

1 site across 1 country: South Korea