Trials / Unknown
UnknownNCT02700581
Impact of Positive End-expiratory Pressure on Hepatic Venous Flow
Impact of Moderate Positive End-expiratory Pressure on Hepatic Venous Flow in Patients Undergoing Cardiac Surgery
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- Sponsor
- Konkuk University Medical Center · Academic / Other
- Sex
- All
- Age
- 19 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine the difference in the impact of moderate positive end-expiratory pressure (PEEP) on hepatic venous flow Doppler in patients undergoing cardiac surgery: conventional versus protective ventilation strategy The possible changes in forward and backward flows (Doppler profiles) of hepatic venous flow at different degrees of PEEP in conventional and protective ventilation strategies are analyzed by using intraoperative transesophageal echocardiography (TEE) in patients undergoing cardiac surgery .
Detailed description
Following data would be determined after 5 min-exposure volume controlled ventilation employing tidal volume of 10 ml/kg and 6 ml/kg with low PEEP (with 2 mmHg) and moderate PEEP (7 mmHg) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=12) 1. sum of forward hepatic venous flow 2. sum of backward hepatic venous flow 3. peak velocity of diastolic hepatic venous flow 4. lung compliance 5. peak airway pressure 6. mean airway pressure 7. other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (CVP), pulmonary capillary
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | low PEEP conventional ventilation | |
| PROCEDURE | moderate PEEP conventional ventilation | |
| PROCEDURE | low PEEP protective ventilation | |
| PROCEDURE | moderate PEEP protective ventilation |
Timeline
- Start date
- 2016-03-01
- Primary completion
- 2016-04-01
- Completion
- 2016-05-01
- First posted
- 2016-03-07
- Last updated
- 2016-03-07
Source: ClinicalTrials.gov record NCT02700581. Inclusion in this directory is not an endorsement.