NCT01819012

Effect of Isoflurane on Tissue Doppler Imaging of Mitral Annulus During Cardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Konkuk University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine Isoflurane's dose-dependent effect on left ventricular (LV) systolic function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular systolic velocity at three different isoflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE) in cardiac surgery patients.

Detailed description

Isoflurane is widely used in cardiac surgery patients due to its beneficial effects, but many studies have shown that isoflurane reduces myocardial contractility in a dose-dependent manner, and compromises left ventricular (LV) function. Tissue Doppler imaging (TDI) of mitral annular velocity during the cardiac cycle has been introduced as a reliable method for analysis of systolic and diastolic LV long-axis function. Efficacy of systolic and diastolic TDI profiles, including systole (S'), early early relaxation (E')and atrial contraction (A') have been suggested to be useful in predicting the impact of isoflurane on LV systolic and diastolic function. The investigators hypothesized that isoflurane, even at a clinical dosage, would affects intraoperative LV systolic function in a dose-dependent manner and thus produce significant changes int the TDI profiles of systolic mitral annular velocity (S'). So the investigators planned to study the changes in S' of lateral mitral annulus at the clinical isoflurane dosage during remifentanil based anesthesia for cardiac surgery.

Conditions

• Valvular Heart Disease
• Ischemic Heart Disease

Interventions

Type	Name	Description
DRUG	Isoflurane 1.0 MAC	10 min-inhalation of each concentration of isoflurane, 1.0 MAC
DRUG	Isoflurane 1.5 MAC	10 min-inhalation of each concentration of isoflurane, 1.5 MAC
DRUG	Isoflurane 2.0 MAC	10 min-inhalation of each concentration of isoflurane, 2.0 MAC

Timeline

• Start date: 2013-03-01
• Primary completion: 2013-11-01
• Completion: 2014-03-01
• First posted: 2013-03-27
• Last updated: 2016-11-02

Locations

1 site across 1 country: South Korea