| Not Yet Recruiting | Characterising the Network-Specific Effects of Piriform Cortex Stimulation Via SEEG NCT07305311 | Xuanwu Hospital, Beijing | N/A |
| Recruiting | Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application NCT06425029 | Dartmouth-Hitchcock Medical Center | N/A |
| Recruiting | Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG NCT06524479 | Xuanwu Hospital, Beijing | N/A |
| Completed | Investigating the Role and Electrophysiological Characteristics of the Human Claustrum Based on SEEG NCT06575413 | Xuanwu Hospital, Beijing | N/A |
| Not Yet Recruiting | Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy NCT06387186 | Elizabeth Anne Thiele | Phase 1 |
| Recruiting | High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Refractory Epilepsy NCT06241963 | Anhui Medical University | N/A |
| Active Not Recruiting | An Automated Navigation System for Deep Brain Electrode Implantation NCT06396494 | Beijing Tiantan Hospital | — |
| Recruiting | Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy NCT05493722 | University of Minnesota | EARLY_Phase 1 |
| Recruiting | Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy NCT06304389 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Recruiting | Optimal Stimulation Parameters to Disrupt Epileptiform Activity NCT06141668 | Massachusetts General Hospital | N/A |
| Unknown | Fenfluramine for the Treatment of Different Types of Developmental and Epileptic Encephalopathies: a Pilot Tri NCT05232630 | Hospital Ruber Internacional | Phase 4 |
| Withdrawn | A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy NCT04753983 | Mayo Clinic | N/A |
| Recruiting | The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy NCT05019885 | Madeline Fields | Phase 2 |
| Completed | Modulation of Emotion Perception in Humans Via Amygdala Stimulation NCT05292183 | Dartmouth-Hitchcock Medical Center | N/A |
| Completed | Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy NCT04770337 | Neuroelectrics Corporation | N/A |
| Terminated | Exercise as Adjunctive Treatment for Refractory Epilepsy NCT04607317 | Wake Forest University Health Sciences | N/A |
| Unknown | Localization of the Reward Positivity to ACC NCT04684797 | University Hospital, Ghent | N/A |
| Withdrawn | Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy NCT03636958 | Assistance Publique Hopitaux De Marseille | N/A |
| Unknown | Galactose Supplementation for the Treatment of MOGHE NCT04833322 | Hospital Ruber Internacional | N/A |
| Unknown | Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Intractable Epilepsy NCT04771065 | University Hospital, Montpellier | — |
| Completed | The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy NCT04545346 | American University | N/A |
| Unknown | Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children NCT04542629 | Assiut University | Phase 4 |
| Terminated | Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Tempora NCT04153175 | Cerebral Therapeutics LLC | Phase 2 |
| Unknown | Tele-epic (Telemedicine for Epilepsy Care) NCT04496310 | Azienda Usl di Bologna | N/A |
| Completed | Safety of Using NaviFUS System in Patients With Drug Resistant Epilepsy NCT03860298 | NaviFUS Corporation | N/A |
| Unknown | Novel Network Analysis of Intracranial Stereoelectroencephalography NCT03916848 | Great Ormond Street Hospital for Children NHS Foundation Trust | N/A |
| Unknown | Feasibility of HOBSCOTCH Telehealth Intervention in Refractory Epilepsy NCT04240977 | Kessler Foundation | N/A |
| Terminated | European Non-interventional Study on Refractory Epilepsy With Developmental Delay NCT04398667 | Zogenix, Inc. | — |
| Unknown | Clinical Utility of Automated Electric Source Imaging in Presurgical Evaluation NCT04218812 | Sándor Beniczky | N/A |
| Unknown | Voronistat in Pediatric Patients With Drug Resistant Epilepsy NCT03894826 | University of Calgary | Phase 2 |
| Terminated | Randomized Controlled Trial on Cardiovascular Exercise in Uncontrolled Epilepsy: NCT03570489 | Vastra Gotaland Region | N/A |
| Completed | Acute and Long Term Effects of VNS on Memory in Patients With Refractory Epilepsy NCT05031208 | University Hospital, Ghent | N/A |
| Recruiting | Atlas of Human Cognition by SEEG (MAPCOG-SEEG) NCT03644732 | University Hospital, Grenoble | — |
| Unknown | Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortic NCT03321240 | University Hospital, Strasbourg, France | — |
| Unknown | Trial to Evaluate the Safety and Effectiveness of Vagus Nerve Stimulation for Children With Refractory Epileps NCT03062514 | Beijing Pins Medical Co., Ltd | N/A |
| Completed | Safety and Therapeutic Measures of Tdcs in Patients With Refractory Focal Epilepsy NCT02866240 | Neuroelectrics Corporation | N/A |
| Withdrawn | Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus NCT03115489 | University of Alabama at Birmingham | Phase 2 / Phase 3 |
| Terminated | Effect of Short-term Theta Frequency Stimulation of the Vagus Nerve on Cognition in Patients With Refractory E NCT03331939 | University of California, Davis | N/A |
| Unknown | Effect of Outpatient Classic Ketogenic Diet in Epileptic Children and Adolescent. NCT03031028 | Tehran University of Medical Sciences | Phase 2 |
| Completed | Long Term Follow-up of Hippocampal DBS for Refractory Epilepsy NCT03404128 | University Hospital, Ghent | — |
| Completed | Clinical Utility of ESI in Presurgical Evaluation of Patients With Epilepsy NCT03533530 | Rigshospitalet, Denmark | N/A |
| Completed | Intrathecal Autologous ADRC Treatment of Autoimmune Refractory Epilepsy NCT03676569 | Mossakowski Medical Research Centre Polish Academy of Sciences | Phase 1 |
| Terminated | Bioavailability, Safety and Tolerability of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®) NCT02474407 | Acorda Therapeutics | Phase 2 |
| Unknown | Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Refractory Epilepsy NCT02602899 | Beijing Pins Medical Co., Ltd | N/A |
| Unknown | Clinical Trial of Vagus Nerve Stimulation for Treatment of Refractory Epilepsy NCT02378792 | Beijing Pins Medical Co., Ltd | EARLY_Phase 1 |
| Completed | Retrospective Evaluation of Perampanel in a French Neurology and Epileptology Department (Hospices Civil de Ly NCT02876289 | Hospices Civils de Lyon | — |
| Unknown | Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy NCT01932502 | St. Joseph's Hospital and Medical Center, Phoenix | Phase 4 |
| Completed | Evaluation of the Modified Atkins Diet in Young Children With Refractory Epilepsy NCT01880333 | Lady Hardinge Medical College | Phase 2 / Phase 3 |
| Completed | Efficacy of a Simplified Modified Atkins Diet in Children With Refractory Epilepsy NCT01899898 | Lady Hardinge Medical College | Phase 2 / Phase 3 |
| Completed | Product Surveillance Registry- Deep Brain Stimulation for Epilepsy NCT01521754 | MedtronicNeuro | — |
| Completed | A Controlled Clinical Trial of Cathodal Transcranial Direct Current Stimulation in Patients With Refractory Ep NCT01763294 | El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez | Phase 2 |
| Unknown | Low Glycemic Index Diet Therapy in Children With Refractory Epilepsy NCT01645072 | All India Institute of Medical Sciences | Phase 3 |
| Completed | Thalidomide Low Threshold in Epilepsy NCT01061866 | National Institute of Neurology and Neurosurgery, Mexico | Phase 1 / Phase 2 |
| Completed | Safety and Efficacy of 333369 in the Treatment of Partial Epilepsy NCT00228969 | SK Life Science, Inc. | Phase 2 |
| Completed | Cardiac Rhythm Abnormalities in Patients With Refractory Epilepsy at High Risk for Sudden Death NCT00203333 | Thomas Jefferson University | — |
| No Longer Available | Expanded Use of Cannabidiol Oral Solution NCT03196934 | MultiCare Health System Research Institute | — |