NCT06425029

Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

SONATA: Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Dartmouth-Hitchcock Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a prospective, placebo-controlled, double-blinded randomized study of self-administered auditory intervention in a naturalistic home environment.

Detailed description

This study aims to replicate and extend findings from prior electrophysiological studies that demonstrated a reduction in epileptiform discharges and seizures in patients living with drug-resistant (medications are not effective) epilepsy after listening to specific music. It is believed to be the first study to examine the effect of daily, self-administered musical stimuli in reduction of epileptiform event detections over days to weeks. The study will enroll a cohort of patients already implanted with NeuroPace Responsive Neurostimulator (RNS) device to treat their epilepsy. This device uses continuous, outpatient electrocorticographic recording data to provide immediate (or 'responsive') closed loop neurostimulation. Primary hypothesis is that patients with drug resistant epilepsy, implanted with RNS, will have fewer epileptic activity episodes (RNS 'long episodes') during the weeks of experimental music intervention. The study team expect to see improvement with daily listening to specific music intervention (experimental, Music A), but not with active comparators (Music B or C). The effect, if any, of music intervention is expected to last at least one week after the intervention period (block) (for each music piece) ends. Secondary hypothesis is that the music listening every day will be associated with improved self-report of mood, quality of life, and self-reported measures of cognition. The study team suspects that this effect will not be limited to just one specific musical piece. This study will also look to determine the feasibility of an at-home, self-administered auditory intervention in drug resistant epilepsy.

Conditions

• Epilepsy
• Refractory Epilepsy
• Music

Interventions

Type	Name	Description
OTHER	Experimental Intervention (Music A)	Participants will be asked to listen to Music A on their personal device daily, at a time most convenient for them.
OTHER	Active Comparator Intervention (Music B)	Participants will be asked to listen to music B on their personal device daily, at a time most convenient for them.
OTHER	Active Comparator Intervention (Music C)	Participants will be asked to listen to music C on their personal device daily, at a time most convenient for them.

Timeline

• Start date: 2025-07-22
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2024-05-22
• Last updated: 2026-01-16

Locations

2 sites across 1 country: United States