NCT05493722

Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Minnesota · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.

Conditions

• Refractory Epilepsy
• Deep Brain Stimulation

Interventions

Type	Name	Description
OTHER	PS and OS stimulation order 1	PS, OS, OS
OTHER	PS and OS stimulation order 2	OS, PS, OS
OTHER	PS and OS stimulation order 3	OS, OS, PS

Timeline

• Start date: 2023-09-15
• Primary completion: 2028-01-15
• Completion: 2030-01-15
• First posted: 2022-08-09
• Last updated: 2025-10-24

Locations

1 site across 1 country: United States