| Active Not Recruiting | Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset E Focal Onset Seizure | Phase 4 | 2024-10-14 |
| Completed | A Randomized, Open-label, Three-way Crossover Study to Evaluate the Relative Bioavailability of 200 Mg Cenobam Healthy Volunteers | Phase 1 | 2022-09-27 |
| Terminated | Safety, Tolerability, PK/PD & Preliminary Efficacy of SKL27969 in Advanced Solid Tumors Patients Advanced Solid Tumor | Phase 1 / Phase 2 | 2022-09-12 |
| Recruiting | Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Chi Seizures, Lennox Gastaut Syndrome | Phase 3 | 2022-04-28 |
| Active Not Recruiting | Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Sei Partial Epilepsy | Phase 3 | 2022-01-14 |
| Completed | Safety Study of Cenobamate in Subjects With Normal Hepatic Function and Subjects With Severe Hepatic Impairmen Hepatic Impairment | Phase 1 | 2021-06-17 |
| Completed | Dose-Escalation Study of Cenobamate (YKP3089) in Pediatric Subjects With Partial-Onset Seizures Partial Epilepsy | Phase 1 | 2021-05-27 |
| Unknown | Randomized, Double-blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in POS Partial Seizure, Focal Seizure | Phase 3 | 2021-03-08 |
| Completed | Bioavailability and Food Effect Study of Cenobamate as an Oral Suspension and Tablet Healthy | Phase 1 | 2020-12-21 |
| Completed | Bioavailability and Food Effect Study of 3 Types of Carisbamate Healthy Subjects | Phase 1 | 2020-08-27 |
| Completed | Single-Dose Escalation Study Followed by a Multiple-Dose Escalation Study of SKL24741 in Healthy Subjects Healthy | Phase 1 | 2020-02-13 |
| Enrolling By Invitation | Cenobamate Open-Label Extension Study for YKP3089C025 Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy | Phase 3 | 2019-08-13 |
| Completed | Carisbamate Safety Study in Adult and Pediatric Subjects With Lennox-Gastaut Syndrome Lennox Gastaut Syndrome | Phase 1 | 2019-05-03 |
| Completed | Carisbamate in Adult & Pediatric Subjects With Lennox-Gastaut Syndrome Lennox Gastaut Syndrome | Phase 1 | 2019-02-07 |
| Completed | Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizur Primary Generalized Epilepsy | Phase 3 | 2018-09-21 |
| Completed | A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users Healthy Volunteer | Phase 1 | 2017-03-08 |
| Completed | Assess the Influence of Cenobamate on the PK of Cytochrome P450 (CYP) Probe Drugs As a Means of Predicting Dru Healthy | Phase 1 | 2017-02-22 |
| Completed | Safety and Pharmacokinetic Study of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures Partial Epilepsy | Phase 3 | 2016-08-03 |
| Completed | A Safety, Tolerability, PK and PD Study of Multiple Oral Doses of SKL15508 in Subjects With Stable Schizophren Schizophrenia | Phase 1 / Phase 2 | 2014-07-01 |
| Completed | A Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week, Dose-Range-Finding Trial of YKP10811 Cap Chronic Idiopathic Constipation | Phase 2 | 2013-10-01 |
| Completed | A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects Wit Partial Epilepsy | Phase 2 | 2013-07-31 |
| Completed | A Phase 2 Study to Evaluate Pharmacodynamics of YKP10811 in Patients With Chronic or Functional Constipation Chronic Constipation, Functional Constipation | Phase 2 | 2012-03-01 |
| Completed | A Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study for the Pain of Diabetic Peripheral Painful Diabetic Neuropathy | Phase 2 | 2012-01-01 |
| Completed | Efficacy and Safety of YKP3089 in Subjects With Treatment Resistant Partial Onset Seizures Partial Epilepsy | Phase 2 | 2011-07-06 |
| Completed | An Efficacy and Safety Study of Carisbamate in the Treatment of Nerve Pain in Diabetics Diabetic Neuropathies | Phase 2 | 2009-05-01 |
| Completed | An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Epilepsy, Partial, Motor, Epilepsy, Complex Partial, Epilepsy, Simple Partial | Phase 3 | 2009-01-01 |
| Completed | A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Parti Epilepsy, Partial, Motor, Epilepsy, Complex Partial, Epilepsy, Simple Partial | Phase 3 | 2009-01-01 |
| Completed | Long Term Effectiveness and Safety Study for RWJ-333369 as Adjunctive Therapy in Korean and Japanese Patients Seizures | Phase 3 | 2008-03-01 |
| Terminated | Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability Epilepsy, Seizures | Phase 3 | 2007-11-01 |
| Terminated | Effectiveness and Safety Study for RWJ-333369 as Adjunctive Therapy in Korean and Japanese Patients With Parti Seizures | Phase 3 | 2007-10-01 |
| Completed | A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor Essential Tremor, Movement Disorders | Phase 2 | 2007-08-01 |
| Completed | Efficacy of YKP3089 in Patients With Photosensitive Epilepsy Epilepsy | Phase 2 | 2007-08-01 |
| Completed | Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neurop Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy | Phase 2 | 2007-03-01 |
| Completed | An Effectiveness and Safety Study With RWJ-333369 (Carisbamate) for the Study of Postherpetic Neuralgia (PHN). Postherpetic Neuralgia, Neuralgia, Herpes Zoster | Phase 2 | 2007-03-01 |
| Completed | An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in P Epilepsy, Complex Partial Seizures, Epilepsy, Complex Partial | Phase 3 | 2007-02-01 |
| Completed | A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. Epilepsy, Epilepsy, Focal, Seizure Disorder | Phase 3 | 2006-11-01 |
| Completed | A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures. Epilepsy, Epilepsy, Focal, Seizure Disorder | Phase 3 | 2006-11-01 |
| Completed | An Open-Label Extension Study of the Effectiveness and Safety of the Investigational Compound RWJ-333369 in Pa Epilepsy, Epilepsies, Partial | Phase 2 | 2005-05-01 |
| Completed | Safety and Efficacy of 333369 in the Treatment of Partial Epilepsy Refractory Epilepsy | Phase 2 | 2005-02-01 |
| Completed | An Open-Label Extension Study to Evaluate the Safety and Effectiveness of RWJ 333369 in Patients With Epilepsy Epilepsy, Epilepsies, Partial | Phase 2 | 2004-07-01 |
| Completed | A Study of the Efficacy of RWJ-333369 in the Prevention of Migraine Migraine Headaches | Phase 2 | 2002-03-01 |
| Approved For Marketing | Cenobamate Expanded Access Program (EAP) Partial Epilepsy | — | — |