| Not Yet Recruiting | A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism NCT07470983 | Shandong Suncadia Medicine Co., Ltd. | Phase 2 |
| Recruiting | Prognosis of Primary Aldosteronism: A Prospective Cohort Study NCT07378176 | Xinjiang Medical University | — |
| Enrolling By Invitation | Genetic Predisposition to High Blood Pressure NCT07181213 | Linkoeping University | N/A |
| Recruiting | The Association Between Primary Aldosteronism and Cognitive Dysfunction NCT07304674 | Xinjiang Medical University | — |
| Recruiting | Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE) NCT07298954 | Shumin Yang | N/A |
| Recruiting | Multi-omics Studies of Primary Aldosteronism NCT07111351 | Peking University First Hospital | — |
| Recruiting | PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism NCT07027254 | Seoul National University Hospital | N/A |
| Not Yet Recruiting | Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Imp NCT06980753 | University of Sao Paulo General Hospital | N/A |
| Recruiting | Steroids-Based Screening for Primary Aldosteronism NCT06941116 | Qifu Li | — |
| Recruiting | Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent Wit NCT06955286 | Qifu Li | — |
| Not Yet Recruiting | The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism. NCT06756737 | Shanghai East Hospital | — |
| Not Yet Recruiting | The Comparison of Single Catheter and Double Catheter Adrenal Vein Sampling Methods Based on the Upper Limb Ap NCT06737848 | Army Medical University, China | N/A |
| Recruiting | Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate NCT06616142 | University Medical Center Groningen | Phase 1 / Phase 2 |
| Recruiting | Overnight Dexamethasone in Primary Aldosteronism Screening NCT06740838 | Medical University of Gdansk | — |
| Enrolling By Invitation | Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors NCT07182175 | Peking University First Hospital | — |
| Recruiting | Statin Combined with Amlodipine Treats Primary Aldosteronism NCT06523465 | Third Military Medical University | Phase 4 |
| Not Yet Recruiting | Study on Postoperative Adrenal Function Assessment in Patients With Primary Aldosteronism NCT06534268 | Ruijin Hospital | — |
| Recruiting | 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism NCT06833437 | Qifu Li | N/A |
| Recruiting | Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy NCT06513585 | Xinjiang Medical University | N/A |
| Recruiting | Finerenone for Patients With Primary Aldosteronism (FAIRY) NCT06457074 | Qifu Li | Phase 4 |
| Recruiting | Dynamic Hormone Profiling and Multimodal Data Capture in Primary Aldosteronism NCT06495983 | Haukeland University Hospital | — |
| Not Yet Recruiting | Evaluation of [68Ga]Ga-PentixaFor PET Imaging for the Identification of Unilateral Adrenal Secretion of ALdost NCT06478875 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Recruiting | REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study NCT06108427 | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | N/A |
| Recruiting | Super Selective Adrenal Artery Embolization for Primary Aldosteronism: a Prospective Cohort Study(SAAE-PA) NCT06513676 | Xinjiang Medical University | — |
| Active Not Recruiting | Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With Hypertension NCT05925569 | Brigham and Women's Hospital | N/A |
| Completed | The Clinical Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism NCT06381323 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 4 |
| Recruiting | Outcome of 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Primary Aldosteronism NCT06238232 | Qifu Li | N/A |
| Recruiting | New Screening and Diagnostic Cut-off Points of PA Patients NCT06571084 | China National Center for Cardiovascular Diseases | — |
| Recruiting | A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery NCT06250699 | Zhe Meng | N/A |
| Recruiting | Application of Al18F-NOTA-Pentixafor PET/CT for Primary Aldosteronism NCT06773663 | Peking Union Medical College Hospital | Phase 1 / Phase 2 |
| Recruiting | Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat NCT06569589 | Jens Titze | — |
| Unknown | Efficacy and Safety of Finerenone vs. Spironolactone in Patients With Primary Aldosteronism NCT06164379 | Shanghai Jiao Tong University School of Medicine | Phase 4 |
| Recruiting | Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day Me NCT06750172 | Peking Union Medical College Hospital | — |
| Recruiting | Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism NCT06597630 | Qifu Li | — |
| Recruiting | Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization NCT06228677 | First Affiliated Hospital of Chengdu Medical College | — |
| Unknown | Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone NCT06047912 | Dr Ian B Wilkinson | — |
| Unknown | CXCR4 Targeted PET Imaging in the Diagnosis and Identification of Primary Aldosteronism NCT06183554 | Xiao Chen | — |
| Completed | Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism NCT05924620 | Chongqing Medical University | Phase 4 |
| Completed | Primary Aldosteronism LC-MS/MS-specific Cutoffs NCT05959863 | Chongqing Medical University | — |
| Completed | Aldosterone Renin Ratio (ARR) Test to Increase Case-detection of Primary Aldosteronism (PA) NCT05757076 | The Cleveland Clinic | — |
| Unknown | Comparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary Aldosteronism NCT05814770 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 4 |
| Completed | Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism NCT05686993 | Queen Mary University of London | N/A |
| Recruiting | Preoperative Supine Time for Adrenal Venous Sampling NCT05658705 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Recruiting | Diagnosing Variable Primary Aldosteronism. NCT05765786 | Queen Mary University of London | — |
| Unknown | Untargeted Metabolomics for Primary Aldosteronism NCT06076473 | Liverpool University Hospitals NHS Foundation Trust | — |
| Recruiting | Nuclear Imaging for Subtype Diagnosis of Primary Aldosteronism NCT05472493 | University of Calgary | Phase 2 |
| Recruiting | Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study NCT05030545 | Brigham and Women's Hospital | Phase 4 |
| Recruiting | The Effect of SAAE on Vascular Endothelial Function in PA Patients NCT05561361 | Second Affiliated Hospital of Nanchang University | — |
| Recruiting | The Effect of SAAE on Ventricular Remodeling in PA Patients NCT05501080 | Second Affiliated Hospital of Nanchang University | N/A |
| Recruiting | Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA NCT05405101 | Queen Mary University of London | N/A |
| Completed | The Plasma Metabolomics Profiling of Primary Aldosteronism NCT06500000 | Third Military Medical University | — |
| Recruiting | Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary Aldosteronism NCT05368090 | Haukeland University Hospital | N/A |
| Unknown | Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World Data NCT06229405 | Seoul National University Hospital | — |
| Recruiting | Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary Aldosteronism NCT07137364 | Third Military Medical University | — |
| Unknown | The Long-term Effect of SAAE and Medical Treatment for Primary Aldosteronism NCT05262660 | First Affiliated Hospital of Chengdu Medical College | — |
| Recruiting | A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China NCT05638269 | Zhujiang Hospital | — |
| Completed | The Diagnostic Performance of 24-hour Urinary Aldosterone for Primary Aldosteronism NCT06236698 | Zhiming Zhu | — |
| Active Not Recruiting | Postmortem Evaluation of Adrenal and Other Endocrine Tumors in Patients With Sudden Death NCT05446779 | Helsinki University Central Hospital | — |
| Completed | 68Ga-Pentixafor PET/CT for the Subtyping Diagnosis of Primary Aldosteronism NCT05131061 | Qifu Li | — |
| Unknown | Prevalence of Primary Aldosteronism in Atrial Fibrillation NCT05973604 | Aristotle University Of Thessaloniki | — |
| Unknown | Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism NCT05826080 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | — |
| Completed | A Study of CIN-107 in Adults With Primary Aldosteronism NCT04605549 | AstraZeneca | Phase 2 |
| Completed | AVS After 1mg DST to Determine Subtype in PA NCT04709185 | Shanghai Zhongshan Hospital | N/A |
| Completed | Renal Cysts and Primary Aldosteronism NCT05435703 | Tampere University Hospital | — |
| Completed | Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism NCT04991961 | Chongqing Medical University | — |
| Completed | Calcium Channel Blockade in Primary Aldosteronism NCT04179019 | Brigham and Women's Hospital | Phase 2 |
| Unknown | CETO First in Human Trial NCT04529018 | University of Cambridge | N/A |
| Completed | Corticotropin Stimulation in Adrenal Venous Sampling for Patients With Primary Aldosteronism(ADOPA) NCT04461535 | Chongqing Medical University | N/A |
| Completed | Prevalence of Primary Aldosteronism Among Hypertensive Patients With Atrial Arythmia NCT04115280 | Centre Hospitalier de PAU | N/A |
| Active Not Recruiting | 11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours NCT06100367 | Changi General Hospital | Phase 2 / Phase 3 |
| Recruiting | Effects of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism NCT04409431 | Third Military Medical University | N/A |
| Completed | Comparison of Three Confirmatory Tests in the Diagnosis of Primary Aldosteronism NCT04193137 | Chongqing Medical University | — |
| Completed | DP13 - A Phase II Study in Patients With Primary Aldosteronism NCT04007406 | Damian Pharma AG | Phase 2 |
| Completed | Clinical and Genetic Investigation of the Association Between Primary Aldosteronism and Thyroid Cancer NCT06068101 | Instituto do Cancer do Estado de São Paulo | — |
| Recruiting | Primary Aldosteronism: Prospective Screening Registry in China NCT04020783 | Shanghai Jiao Tong University School of Medicine | — |
| Unknown | Adrenal Artery Ablation for Primary Aldosteronism NCT03653845 | Third Military Medical University | Phase 3 |
| Completed | Primary Aldosteronism and Surgically Curable Forms in Hypertension Patients Using 11C-Metomidate NCT03990701 | Changi General Hospital | EARLY_Phase 1 |
| Completed | Prevalence of Primary Aldosteronism in Patients With Stroke NCT03789357 | Changi General Hospital | — |
| Completed | Adrenal Artery Ablation Treats Primary Aldosteronism NCT03398785 | Third Military Medical University | Phase 3 |
| Completed | Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism NCT03500120 | Chongqing Medical University | — |
| Completed | Prevalence of Primary Aldosteronism in Young Adults With Acute Stroke NCT04203420 | Chongqing Medical University | — |
| Completed | Open-label Study on Treatment of Primary Aldosteronism With Everolimus NCT03174171 | University Hospital, Basel, Switzerland | Phase 2 |
| Completed | Screening for Primary Aldosteronism in a Population of Patients With Hypertension NCT03105531 | Uppsala University | — |
| Completed | Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldoster NCT03174847 | Changi General Hospital | — |
| Completed | Prospective Evaluation of Confirmatory Testing for Primary Aldosteronism NCT04422756 | University of Calgary | — |
| Completed | IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients NCT02945904 | Queen Mary University of London | — |
| Completed | Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism NCT02756754 | University Hospital, Toulouse | N/A |
| Unknown | Outcome of Patients With Primary Aldosteronism NCT04428827 | Changi General Hospital | — |
| Recruiting | Chongqing Primary Aldosteronism Study NCT03224312 | Chongqing Medical University | — |
| Completed | Study of CS-3150 in Patients With Primary Aldosteronism NCT02885662 | Daiichi Sankyo Co., Ltd. | N/A |
| Completed | Predicting Reduction of Hypertension After Adrenalectomy for Primary Aldosteronism: a Multicenter Analysis NCT04761354 | UMC Utrecht | — |
| Completed | Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism NCT04269928 | Third Military Medical University | — |
| Completed | Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas NCT02362308 | Vanderbilt University | — |
| Unknown | Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study NCT02257450 | International Islamic University Malaysia | — |
| Withdrawn | Microvascular Function in Primary Aldosteronism NCT02096939 | Maastricht University Medical Center | — |
| Completed | The Effect of Disease-specific Treatment on Bone Turnover Markers in Patients With Primary Aldosteronism NCT02216721 | University Malaysia Sarawak | — |
| Completed | Optimizing Diagnosis Of Primary Aldosteronism NCT02755519 | Chongqing Medical University | — |
| Completed | Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment NCT01728493 | Radboud University Medical Center | — |
| Unknown | Prospective Study on Primary Aldosteronism in Resistant Hypertension NCT04213963 | University of Turin, Italy | — |
| Unknown | Influence of Synacthen Infusion on the Results of Adrenal Venous Sampling in Patient With Primary Aldosteronis NCT02127840 | Charles University, Czech Republic | Phase 4 |
| Unknown | Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin A NCT00917345 | National Taiwan University Hospital | — |
| Unknown | Metabolic Syndrome and Insulin Resistance in Primary Aldosteronism NCT00173082 | National Taiwan University Hospital | — |
| Completed | Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldostero NCT04378387 | University of Turin, Italy | — |
| Completed | Short- and Long-term Outcomes of Adrenalectomy for Primary Aldosteronism NCT06192810 | University College London Hospitals | — |