NCT05561361

The Effect of SAAE on Vascular Endothelial Function in PA Patients

The Effect of Selective Adrenal Artery Embolism on Vascular Endothelial Function in Patients With Primary Aldosteronism Based on Brachial Artery Flow-mediated Relaxation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Second Affiliated Hospital of Nanchang University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation

Detailed description

After being informed about the study and potential risks,all patients giving written informed consent will undergo a 2-week screening period to determine eligibility for study entry.At week 0,patients who meet the eligibility requirements will be divided into Superselective adrenal arterial embolization group or spironolactone therapy group,according to the patient's surgical indications and wishes.

Conditions

• Primary Aldosteronism

Interventions

Type	Name	Description
PROCEDURE	Super selective adrenal artery embolization	Superselective adrenal arterial embolization is an operation to inject embolic agent into adrenal artery through catheter to embolize part of adrenal gland, so as to reduce the secretion of adrenal hormone and reduce blood pressure.
DRUG	Spironolactone	Aldosterone receptor antagonists are recommended by guidelines for the treatment of bilateral primary aldosteronism.

Timeline

• Start date: 2022-10-01
• Primary completion: 2026-11-30
• Completion: 2026-12-31
• First posted: 2022-09-30
• Last updated: 2025-12-15

Locations

1 site across 1 country: China