NCT05501080

The Effect of SAAE on Ventricular Remodeling in PA Patients

The Effect of Selective Adrenal Artery Embolization and Spironolactone on Ventricular Remodeling in Nondominant Lateral Secretory Primary Aldosteronism： A Randomized Controlled Clinical Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 112 (estimated)
• Sponsor: Second Affiliated Hospital of Nanchang University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.

Detailed description

After being informed about the study and potential risks,all patients giving written informedconsent will undergo a 2-week screening period to determine eligibility for study entry.Atweek 0,patients who meet the eligibility requirements will be randomized in a 1:1 ratio to Superselective adrenal arterial embolization group or spironolactone therapy group.

Conditions

• Primary Aldosteronism

Interventions

Type	Name	Description
OTHER	Super selective adrenal artery embolization	Superselective adrenal arterial embolization is an operation to inject embolic agent into adrenal artery through catheter to embolize part of adrenal gland, so as to reduce the secretion of adrenal hormone and reduce blood pressure.
DRUG	Spironolactone	Aldosterone receptor antagonists are recommended by guidelines for the treatment of bilateral primary aldosteronism.

Timeline

• Start date: 2022-09-01
• Primary completion: 2025-09-01
• Completion: 2025-12-31
• First posted: 2022-08-15
• Last updated: 2025-05-16

Locations

1 site across 1 country: China