NCT04991961

Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism

Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Primary Aldosteronism：a Prospective Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 341 (actual)
• Sponsor: Chongqing Medical University · Academic / Other
• Sex: All
• Age: 10 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

To evaluate the effect of anti-hypertensive medication on efficiency of primary aldosteronism screening and confirmatory test, and to determine the appropriate diagnostic cutoff value for Chinese hypertension patients during antihypertensive drugs therapy.

Detailed description

Aldosterone-Renin ratio (ARR)is currently the most reliable means available for screening for primary aldosterone（PA）while captopril challenging test is the widely used confirmatory test. However, some antihypertensive drugs may interfer aldosterone and renin levels. Thus, PA guidelines suggest that antihypertensive drugs should be withdraw or change therapy before screening. But withdraw/changing the therapy is inconvenient for patients. The investigators prepare to start a prospective study through recruiting hypertension patients, completing the ARR screening and captopril challenging test before and after withdraw/change therapy.

Conditions

• Hypertension
• Primary Aldosteronism

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	withdraw antihypertensive drugs	patients need to withdraw of all antihypertensive drugs or change therapy to Doxazosin/Diltiazem for 2-4 weeks prior

Timeline

• Start date: 2020-09-15
• Primary completion: 2024-10-31
• Completion: 2024-10-31
• First posted: 2021-08-05
• Last updated: 2025-08-14

Locations

2 sites across 1 country: China