| Not Yet Recruiting | Human Models of Selective Insulin Resistance: Pancreatic Clamp NCT06558422 | Columbia University | Phase 1 |
| Not Yet Recruiting | Enhancing Mental and Physical Health of Women Veterans 3.0 NCT07356479 | VA Office of Research and Development | N/A |
| Recruiting | Effect of Insulin Lowering on Lipogenesis NCT07403604 | Columbia University | Phase 1 |
| Not Yet Recruiting | Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects NCT07377097 | Charite University, Berlin, Germany | N/A |
| Recruiting | Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center NCT06897982 | Cedars-Sinai Medical Center | N/A |
| Recruiting | Heat and Exercise in Aging as Therapy (HEAT) NCT06580964 | Texas Tech University | N/A |
| Recruiting | Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control NCT06118931 | University of Toronto | N/A |
| Recruiting | Role of Aging and Individual Variation in Exercise Training Responsiveness NCT06471569 | Duke University | N/A |
| Recruiting | PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes NCT06690788 | University of Utah | N/A |
| Recruiting | Antidiabetic Effect of Olive Pomace Oil NCT06723886 | Instituto de Ciencia y Tecnología de Alimentos y Nutrición | N/A |
| Recruiting | Effectiveness of the Brazilian Diabetes Prevention Program NCT06426277 | Beneficência Portuguesa de São Paulo | N/A |
| Completed | Feasibility and Preliminary Effects of Fasting-Mimicking Diet in Asian Americans With Prediabetes NCT06518798 | University of California, Irvine | N/A |
| Withdrawn | Dexamethasone/Pancreatic Clamp P&F NCT06126354 | Columbia University | Phase 1 |
| Not Yet Recruiting | Henagliflozin's Impact on Prediabetes Remission NCT06448130 | Shandong Provincial Hospital | Phase 4 |
| Recruiting | Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol) NCT06481020 | University of Valencia | N/A |
| Completed | Effects of Clinical Pilates Exercises on Glycemic Control, Blood Lipids and Physical Fitness Parameters in Pre NCT06452940 | Eastern Mediterranean University | N/A |
| Recruiting | Human Models of Selective Insulin Resistance: Alpelisib, Part I NCT06354088 | Columbia University | Phase 1 |
| Recruiting | Effect of Zinc on Glucose Homeostasis NCT05835037 | University of Maryland, Baltimore | Phase 4 |
| Unknown | Development of PI-ML Algorithm for Prediction of the Real-time Risk for Developing Pre-diabetes NCT06195566 | Jelizaveta Sokolovska | — |
| Completed | Family-based Prevention of Diabetes Through Eating Habits and Physical Activity NCT05694351 | Slagelse Hospital | N/A |
| Unknown | Evaluation of the Safety and Efficacy of SGLT2 Inhibitors in Pre-diabetic Patients NCT05914857 | Yangjin | Phase 2 |
| Completed | Pancreatic Clamp in NAFLD NCT05724134 | Columbia University | Phase 1 |
| Recruiting | Sleep for Health Study on the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk NCT06067139 | Kaiser Permanente | N/A |
| Not Yet Recruiting | Small Steps for Big Changes - Recipe for Health NCT05962983 | University of British Columbia | N/A |
| Completed | Glycemic Effect of Diazoxide in NAFLD NCT05729282 | Columbia University | Phase 1 |
| Active Not Recruiting | OXXYNEA® GS: Study for Glycaemia Management NCT05926947 | Fytexia | N/A |
| Completed | Characterization of the "Transfusion-dependent Prediabetes" Using Continuous Glucose Monitoring NCT06533618 | University of Campania Luigi Vanvitelli | N/A |
| Completed | Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile in Prediabetic and Healthy Subjects NCT05887791 | Rousselot BVBA | N/A |
| Unknown | Mobile App for Risk Reduction of Type 2 Diabetes NCT06117098 | Oslo Metropolitan University | N/A |
| Recruiting | Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes NCT02915198 | VA Office of Research and Development | Phase 4 |
| Completed | Brazilian Diabetes Prevention Program: Pilot Study NCT05689658 | Beneficência Portuguesa de São Paulo | N/A |
| Unknown | The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity. NCT05701813 | Azienda Ospedaliera Universitaria Integrata Verona | N/A |
| Completed | Couple-Based Lifestyle Intervention to Prevent Type 2 Diabetes NCT05695170 | University of Utah | N/A |
| Active Not Recruiting | Use of Empagliflozin to Treat Prediabetes NCT05426525 | Oregon State University | Phase 4 |
| Unknown | Acupuncture for Impaired Glucose Tolerance in Overweight/Obese Population NCT05347030 | Yan Yan | N/A |
| Recruiting | Genetics of the Acute Response to Oral Semaglutide NCT05340868 | Medical University of Bialystok | N/A |
| Completed | Clinical Study to Assess the Long-term Effect of Pep2Dia® on Glucose Homeostasis in Prediabetic Subjects NCT05391854 | Ingredia S.A. | N/A |
| Completed | Implementation and Evaluation of a Diabetes Prevention Clinical Pathway in Primary Care NCT05265312 | Johns Hopkins University | N/A |
| Recruiting | Exercise Training and Fat Metabolism in Postmenopausal Women NCT05351476 | Florida State University | N/A |
| Completed | Mode of Action (MoA) Study of TOTUM-63 in Individuals at Increased Cardio-metabolic Risk NCT05369585 | Valbiotis | N/A |
| Active Not Recruiting | Efficacy of High-intensity Exercise in Women With Prediabetes NCT05435196 | Universidad Popular Autónoma del Estado de Puebla | N/A |
| Completed | Feasibility of Prediabetes Remission in Adults With Coronary Heart Disease NCT05459987 | Montreal Heart Institute | N/A |
| Completed | Impact of Sorghum Rice on Beta-Cell Function and Insulin Resistance in Prediabetes NCT07298304 | Dr. Soetomo General Hospital | N/A |
| Completed | Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes NCT05193578 | Jan Frystyk | Phase 2 |
| Withdrawn | Healthy Hearts: Leveraging the Diabetes Prevention Program to Decrease Health Disparities in Women of Reproduc NCT05379296 | The University of Texas Medical Branch, Galveston | N/A |
| Completed | mHealth Intervention to Prevent Type 2 Diabetes Mellitus (Phase II Study) NCT05110625 | Fundació d'investigació Sanitària de les Illes Balears | N/A |
| Unknown | Flaxseed Supplementation in Prediabetic Adults (LINAPRED) NCT05245825 | Centro Universitario de Ciencias de la Salud, Mexico | N/A |
| Active Not Recruiting | Enhancing Mental and Physical Health of Women Veterans NCT05050266 | VA Office of Research and Development | N/A |
| Completed | Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Prog NCT05056376 | Johns Hopkins University | N/A |
| Recruiting | Restoring 24-hour Substrate Rhythmicity to Improve Glycemic Control by Timing of Lifestyle Factors NCT05123963 | Université de Sherbrooke | N/A |
| Completed | IMplementation of the Family Support PRogramme A Healthy School Start to Prevent OVErweight and Obesity (IMPRO NCT04984421 | Karolinska Institutet | N/A |
| Unknown | Mobile Health Application of Screening and Early Intervention for Prediabetic Patient at Primary Health Cares NCT04979559 | Gadjah Mada University | N/A |
| Completed | Clinical Trial to Evaluate the Efficacy and Safety of the Probiotic Strains Limosilactocillus Reuteri DSM 3291 NCT04767789 | Novozymes A/S | N/A |
| Unknown | Study to Assess the Effects of Non Digestible Carbohydrates on Long-Term Glucose Homeostasis in Untreated Pred NCT04767672 | Tereos | N/A |
| Completed | Effectiveness of a Nurse-led Personalized Telephone Intervention on Lifestyle Changes in Diabetes Prevention. NCT04735640 | University of the Balearic Islands | N/A |
| Unknown | Effects of TCM on Beta-cell Function and Insulin Resistance in High Risk Chinese Individuals for T2D (TCM_PDia NCT04441216 | Chinese University of Hong Kong | N/A |
| Completed | Effect of Totum-63 on Glucose and Lipid Homeostasis in Subjects With Dysglycemia (REVERSE-IT) NCT04423302 | Valbiotis | N/A |
| Completed | Antimicrobial Photodynamic Therapy in Chronic Periodontitis and Diabetes Mellitus NCT04857346 | King Saud University | Phase 2 / Phase 3 |
| Terminated | Effects of dapaglifloziN Therapy on Myocardial Perfusion Reserve in Prediabetic Patients With Stable coronarY NCT04330079 | CHEOL WHAN LEE, M.D., Ph.D | Phase 4 |
| Completed | Investigation of Milk Peptides (Pep2Dia®) on Postprandial Blood Glucose Profile in Prediabetic Subjects NCT04375449 | Ingredia S.A. | N/A |
| Unknown | Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D NCT04335513 | University of Colorado, Denver | N/A |
| Completed | Impact of Digital Therapeutic on Metabolic Parameters NCT04573296 | Vitadio s.r.o. | N/A |
| Active Not Recruiting | Evaluation of a Telehealth DPP With Medicare Patients at the University of Mississippi Medical Center NCT04822480 | University of Mississippi Medical Center | — |
| Unknown | Effect of Real-time Continuous Glucose Monitoring System in Overweight or Obese Adults With Prediabetes NCT04099550 | Pusan National University Hospital | N/A |
| Completed | Effectiveness of Diabetes Prevention Education Program on Diabetes Prevention Among Prediabetes Population in NCT04074148 | Norwegian University of Science and Technology | N/A |
| Unknown | Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes NCT04131582 | Universidad de Guanajuato | Phase 3 |
| Unknown | Effect of Low Dose Combination of Linagliptin + Metformin to Prevent Diabetes NCT04134650 | Universidad de Guanajuato | Phase 3 |
| Completed | The Effect of Black Currant on Postprandial Glucose Metabolism NCT04150926 | University of Eastern Finland | N/A |
| Completed | Presessions for the National Diabetes Prevention Program NCT04022499 | Denver Health and Hospital Authority | N/A |
| Completed | Effects of 2 Weeks Treatment With Dapagliflozin in Subjects With an Impaired Glucose Homeostasis on Nocturnal NCT03721874 | Maastricht University | Phase 4 |
| Completed | STAR Study Investigating Performance and Safety of the Medical Device SiPore15™ NCT03823027 | Sigrid Therapeutics AB | N/A |
| Unknown | High Intensity Interval Training in Prediabetes NCT03773731 | Medical University of Vienna | N/A |
| Completed | Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals NCT03823664 | Hacettepe University | — |
| Completed | A Mediterranean Intervention on Prediabetic Children NCT05424107 | Pilar Aparicio Martinez | N/A |
| Completed | Effects of Whey Protein Pre-meals on Post-prandial Glucose NCT05112146 | Société des Produits Nestlé (SPN) | N/A |
| Unknown | China Protection Trial of Glucose Metabolism by Pitavastatin in Patients With Prediabetes and Hypertension NCT03532620 | Jun Tao | Phase 4 |
| Completed | The Effects of Light on Glucose Metabolism NCT03829982 | Maastricht University | N/A |
| Completed | United for Health: Type 2 Diabetes Prevention in Latino Teens NCT03527641 | Colorado State University | N/A |
| Completed | RCT of a Polyherbal Dietary Supplement for Prediabetes NCT03388762 | University of Maryland, Baltimore | N/A |
| Unknown | PRuDENTE; Diabetes Prevention Via Exercise, Nutrition and Treatment NCT03194009 | Instituto Nacional de Salud Publica, Mexico | N/A |
| Unknown | Evaluation of a Community Health Program for the Prevention of Type 2 Diabetes and Other Cardio-metabolic Risk NCT03049839 | Universidad del Norte | N/A |
| Completed | A Mobile Phone-based Program for Adults With Prediabetes NCT03025607 | University of Michigan | N/A |
| Completed | Diabetes Prevention for Mexican Americans NCT03208010 | University of Texas at Austin | N/A |
| Completed | Effects of Branch Chain Amino Acids on Glucose Tolerance in Obese Pre-Diabetic Subjects NCT02684565 | University of California, Los Angeles | N/A |
| Completed | Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine NCT04088461 | Universidad de Guanajuato | Phase 4 |
| Unknown | Effect of Melatonin on Cardiometabolic Risk- FULL NCT02681887 | Brigham and Women's Hospital | Phase 3 |
| Unknown | Serum Sphingolipidomic Analyses in Healthy, Diabetic and Prediabetic Subjects NCT02826759 | First Affiliated Hospital Xi'an Jiaotong University | — |
| Completed | Health Outcomes of Teens Participating in Summer Employment Immersion Programs NCT02886208 | Indiana University | N/A |
| Withdrawn | Autoimmune Diabetes Accelerator Prevention Trial NCT02881528 | University of Exeter | Phase 4 |
| Unknown | Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples NCT04011228 | Medical University of Vienna | — |
| Completed | The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes NCT02695810 | Steno Diabetes Center Copenhagen | Phase 2 |
| Completed | Coronary Artery Disease Progression in Patients With Prediabetes NCT02744976 | Pauls Stradins Clinical University Hospital | Phase 4 |
| Completed | Pilot Stair Climbing Study NCT02827383 | Jennifer Gay | N/A |
| Terminated | Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population. NCT02631148 | Brigham and Women's Hospital | Phase 2 |
| Completed | Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes NCT03004612 | Universidad de Guanajuato | Phase 4 |
| Completed | Finding the Patient's Voice Diabetes Prevention Programs NCT02700503 | Indiana University | N/A |
| Completed | Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes NCT02678390 | Université de Sherbrooke | N/A |
| Completed | Improving Physical Activity Through a mHealth Intervention in Cardio-metabolic Risk Patients NCT02551640 | Massachusetts General Hospital | N/A |
| Unknown | Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics) NCT02561377 | Nanjing University of Traditional Chinese Medicine | N/A |
| Completed | ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus NCT02330549 | Tobira Therapeutics, Inc. | Phase 2 |
| Completed | A Pharmacist-Coordinated Implementation of the Diabetes Prevention Program NCT02384109 | University of California, Los Angeles | N/A |
| Unknown | Meta-analyses of Liquid Versus Solid Calories and Body Weight NCT02702440 | John Sievenpiper | — |
| Terminated | Prevention Trial: Immune-tolerance With Alum-GAD (Diamyd) and Vitamin D3 to Children With Multiple Islet Autoa NCT02387164 | Lund University | Phase 2 |
| Withdrawn | The Effect of Liraglutide in Patients With Prediabetes and Kidney Failure NCT02284230 | Bo Feldt-Rasmussen | Phase 2 |
| Completed | Culturally-adapted Diabetes Prevention Lifestyle Intervention for Latinos (E-LITE Latinos) NCT02459691 | Palo Alto Medical Foundation | N/A |
| Terminated | Effect of Exercise on Insulin Resistance NCT01941277 | Alere San Diego | N/A |
| Completed | Use of Track Health Function of the MyHealthevet Personal Health Record NCT02921425 | VA Office of Research and Development | N/A |
| Completed | Lifestyle-Related Health Outcomes in Prediabetes and Diabetes NCT02535169 | Indiana University | N/A |
| Completed | Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes NCT02754739 | Samsung Medical Center | Phase 4 |
| Completed | Text Messaging for Weight Loss NCT02063048 | Denver Health and Hospital Authority | N/A |
| Completed | Physical Activity and Obesity NCT02060240 | Oregon Health and Science University | N/A |
| Recruiting | Wake Forest Alzheimer's Disease Clinical Core NCT03140865 | Wake Forest University Health Sciences | — |
| Completed | Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism. NCT01956929 | Mayo Clinic | Phase 1 |
| Completed | Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease NCT01884545 | Duke University | N/A |
| Completed | Minnesota Medicaid Incentives to Prevent Chronic Disease NCT02422420 | Minnesota Department of Human Services | N/A |
| Completed | Macronutrient Effects on Alzheimer's Disease (MEAL-2) NCT02463084 | Wake Forest University Health Sciences | N/A |
| Completed | Evaluating for Type-2 Diabetes in the Very Early Postpartum Period NCT01988987 | NYU Langone Health | — |
| Completed | Diabetes Screening & Prevention for People With Learning (Intellectual) Disabilities:STOP Diabetes Study NCT02513277 | University of Leicester | — |
| Completed | Use of Mobile Technology to Promote Sustained Lifestyle Changes to Prevent Type 2 Diabetes in India and the UK NCT01570946 | India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals | N/A |
| Completed | Multicomponent Telecare Model for Supporting Prediabetes Patients NCT01671293 | Pontificia Universidad Catolica de Chile | N/A |
| Completed | Glucose Metabolism Effects of Vitamin D Supplementation in Prediabetes NCT01479933 | University of Eastern Finland | N/A |
| Terminated | DPP-4 Inhibition and TZD for DM Prevention NCT01006018 | Emory University | N/A |
| Completed | Effect of Atorvastatin on Glycemic Control in Prediabetic Patients NCT02470455 | Shri Ramachandra Bhanj Medical College | — |
| Completed | Evaluation of the Translation of the DE-PLAN Program for the Primary Prevention of Type 2 Diabetes in Routine NCT01365013 | Basque Health Service | Phase 4 |
| Completed | Effect of Mulberry Leaf Extract on Blood Glucose NCT01385865 | Ewha Womans University | N/A |
| Completed | Safety & Effectiveness on Vascular Structure and Function of ACZ885 in Atherosclerosis and Either T2DM or IGT NCT00995930 | Novartis Pharmaceuticals | Phase 2 |
| Completed | The Effect of Vitamin K Supplementation on Glucose Metabolism NCT00960973 | Seoul National University Hospital | Phase 4 |
| Completed | Opportunistic Screening for Prediabetes and Early Diabetes in Primary Care NCT00787839 | US Department of Veterans Affairs | — |
| Completed | Antihypertensive Medication Exposure as Risk for Impaired Glucose Tolerance: A PEAR Sub-Study NCT01099397 | University of Florida | — |
| Completed | Undiagnosed Diabetes in a Dental Setting NCT01711385 | Columbia University | N/A |
| Completed | Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation NCT00470262 | VA Office of Research and Development | N/A |
| Completed | Can Structured Education Promote Physical Activity in Those Identified With an Increased Risk of Developing Di NCT00566319 | University Hospitals, Leicester | N/A |
| Terminated | Rimonabant In Prediabetic Subjects To Delay Onset Of Type 2 Diabetes NCT00325650 | Sanofi | Phase 3 |
| Completed | Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS) NCT00455403 | Washington University School of Medicine | N/A |
| Completed | Efficacy and Safety of Vildagliptin in Subjects With Impaired Glucose Tolerance NCT00237250 | Novartis | Phase 3 |
| Completed | Translating the DPP Into the Community NCT00302042 | Northwestern University | N/A |
| Completed | Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance NCT00122447 | Emory University | N/A |
| Unknown | Pancreatic Islet Function, Insulin Sensitivity, and Chronic Complications in Pre-Diabetes NCT00172796 | National Taiwan University Hospital | — |
| Completed | Education, Counseling, and Drug Therapy to Reduce Symptoms of Metabolic Syndrome NCT00129792 | Oregon Health and Science University | N/A |
| Completed | Noninvasive Skin Spectroscopy for Diabetes Screening NCT00358254 | InLight Solutions | — |
| Terminated | Instrument Development of Screening Prediabetes Patients NCT00308646 | China Medical University Hospital | — |
| Completed | Chloroquine to Treat People With Metabolic Syndrome Aim2 (ARCH-MS) NCT00455325 | Washington University School of Medicine | Phase 2 |
| Completed | Chromium Picolinate for the Treatment of Metabolic Syndrome NCT00128154 | National Center for Complementary and Integrative Health (NCCIH) | N/A |
| Completed | Study of Vanadium Supplement in Patients With Impaired Glucose Tolerance NCT00561132 | Unidad de Investigacion Medica en Epidemiologia Clinica | Phase 3 |
| Completed | A Study of Attitudes About the Risk of Developing Type 2 Diabetes NCT00323349 | Eastern Virginia Medical School | N/A |
| Completed | Type 2 Diabetes Primary Prevention for At Risk Girls NCT00063674 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Phase 2 / Phase 3 |
| Completed | Live Enterovirus Vaccine and Type 1 Diabetes NCT02961595 | Tampere University | Phase 1 |