NCT00960973

The Effect of Vitamin K Supplementation on Glucose Metabolism

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 42 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: Male
• Age: 20 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.

Detailed description

Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.

Conditions

• Diabetes
• Prediabetic State

Interventions

Type	Name	Description
DRUG	Menatetrenone	Menatetrenone 30 mg, 3 times a day for 4 weeks
DRUG	Placebo	Placebo

Timeline

• Start date: 2009-09-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2009-08-18
• Last updated: 2011-08-10

Locations

1 site across 1 country: South Korea