NCT03829982

The Effects of Light on Glucose Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Maastricht University · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose and/or impaired glucose tolerance.

Detailed description

Light has a major influence on the biological clock and several studies suggest that bright light during the day and dim light in the evening are beneficial for the circadian timing system. Nowadays, large parts of the population spend 90% of their time indoors and are thereby exposed to artificial lighting instead of daylight. The artificial light levels are relatively low during the day and continue relatively late in the evening. The lack of a clear natural light-dark cycle could results in delayed timing of the biological clock relative to the behaviour. Optimizing the lighting conditions under controlled laboratory settings might lead to better alignment of the biological clock, which in turn could improve metabolic parameters such as glucose control.

Conditions

• Diabetes Mellitus, Type 2
• Glucose Intolerance
• Prediabetic State

Interventions

Type	Name	Description
BEHAVIORAL	Exposure to bright light during the day	Participants will be exposed to bright light (1250 lux) between 8:00 and 18:00 and to dim light (5 lux) between 18:00 and 23:00.
BEHAVIORAL	Exposure to dim light during the day	Participants will be exposed to dim light (10 lux) between 8:00 and 18:00 and to dim light (1250 lux) between 18:00 and 23:00.

Timeline

• Start date: 2018-07-13
• Primary completion: 2020-02-07
• Completion: 2020-02-07
• First posted: 2019-02-04
• Last updated: 2020-09-24

Locations

1 site across 1 country: Netherlands