Trials / Completed
CompletedNCT02463084
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
Macronutrient Effects on Alzheimer's Disease: HTN and IR (Hypertension and Insulin Resistance) (MEAL-2)
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Wake Forest University Health Sciences · Academic / Other
- Sex
- All
- Age
- 45 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain structure, function, and perfusion, as well as on blood and cerebrospinal fluid levels of amyloid-beta (Aβ), insulin, lipids (total cholesterol, HDL, LDL, oxidized LDL, and triglycerides), cytokines, apolipoprotein E (ApoE), apolipoprotein J, cortisol, soluble low density lipoprotein receptor-related protein (sLRP), and glucose in middle-aged adults (45-65 years of age) with normal cognition or mild cognitive impairment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Low Diet | a 28-day course of 3 meals per day plus 2 snack that are either low in saturated fats, glycemic index and salt. |
| OTHER | High Diet | a 28-day course of 3 meals per day plus 2 snack that are either high in saturated fats, glycemic index and salt. |
Timeline
- Start date
- 2013-03-01
- Primary completion
- 2016-06-01
- Completion
- 2016-06-01
- First posted
- 2015-06-04
- Last updated
- 2018-08-09
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02463084. Inclusion in this directory is not an endorsement.