| Not Yet Recruiting | A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Infants Receiv NCT07406347 | GlaxoSmithKline | Phase 1 |
| Not Yet Recruiting | A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Toddlers 12 to NCT07406334 | GlaxoSmithKline | Phase 1 |
| Recruiting | Trial to Evaluate Safety and Immune Response of an Investigational Pneumococcal Vaccine in Adults Aged 50 To 6 NCT07428759 | GlaxoSmithKline | Phase 1 |
| Not Yet Recruiting | MP101 in Adults With Acute Pseudomonas Aeruginosa Pneumonia NCT07492771 | MicrobiotiX Co., Ltd | Phase 1 |
| Completed | Artificial Intelligence-Based Evaluation of Chest X-Rays in Ventilator-Associated Pneumonia NCT07509697 | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | — |
| Not Yet Recruiting | Urine Pneumococcal Antigen Project NCT07181200 | Liverpool School of Tropical Medicine | — |
| Active Not Recruiting | A Trial to Evaluate the Safety and Immune Response of an Investigational Pneumococcal Vaccine in Adults 50 To NCT07105722 | GlaxoSmithKline | Phase 1 |
| Not Yet Recruiting | Antimicrobial Therapeutic Drug Monitoring During Lung Transplant Perioperative Phase NCT06583642 | Policlinico Hospital | — |
| Recruiting | Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia - ToolCAP NCT06670833 | University of Bern | N/A |
| Not Yet Recruiting | " a Randomized Pilot Study of the Benefit of Nebulized Amikacin in the Treatment of Gram-negative Bacillus Pne NCT06602557 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | Comparison Between the Progostic Value of the Procalcitonin and the Platelet/Total Leukocytic Count Ratio in S NCT06991686 | Ain Shams University | — |
| Recruiting | Rapid De-escalation of Anti-MRSA Therapy Guided by S. Aureus Nares Screening in Case of Pneumonia NCT06238297 | University of Bari Aldo Moro | N/A |
| Completed | Pneumonia Direct Pilot NCT06181669 | Duke University | — |
| Unknown | Diagnostic Accuracy of Pocket-size Lung Ultrasound in Pneumonia Etiology and Complications in Hospitalized Chi NCT06296693 | Centro Hospitalar Universitário de Santo António | N/A |
| Unknown | Eravacycline Combination Therapy for MRAB NCT06282835 | Fujian Medical University Union Hospital | — |
| Completed | Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients NCT05976581 | Jonathan Baghdadi | N/A |
| Completed | CPAP Therapy Through a Helmet or a Full Face Mask in Patients With Acute Hypoxemic Respiratory Failure: Cross- NCT06113432 | I.M. Sechenov First Moscow State Medical University | N/A |
| Active Not Recruiting | Blinded Efficacy and Safety Study of CAL02 IV Plus SOC in Subjects With Severe Community-Acquired Bacterial Pn NCT05776004 | Eagle Pharmaceuticals, Inc. | Phase 2 |
| Recruiting | Different Methods of Aerosolized Polymyxin B Inhalation for Treating Carbapenem-Resistant Gram-Negative Bacter NCT07086391 | Fujian Medical University Union Hospital | — |
| Withdrawn | Cultures in PICU Patients Compared to Healthy Children NCT03418272 | State University of New York at Buffalo | — |
| Terminated | Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic Fi NCT05561764 | Hartford Hospital | Phase 4 |
| Completed | Application of the Recommendations of the SPLIF (French Society of Infectious Pathology) in a Geriatric Popula NCT06307730 | Centre Hospitalier de Saint-Denis | — |
| Completed | A Phase 2 Study to Evaluate the Safety, Tolerability, and Immune Response of AFX3772 Vaccine in Healthy Infant NCT05412030 | GlaxoSmithKline | Phase 2 |
| Unknown | Avoidable Hospitalizations/ Emergency Department Visits- Systematic Review and Meta-synthesis of Qualitative R NCT05456906 | Kaohsiung Medical University | — |
| Completed | Cefiderocol Pharmacokinetics in Adult Patients With Cystic Fibrosis NCT05314764 | Hartford Hospital | Phase 4 |
| Completed | Prevalence and Serotype of Streptococcus Pneumoniae Hospitalized Adult With Community-Acquired Pneumonia NCT05173727 | Dr Cipto Mangunkusumo General Hospital | — |
| Completed | Derivation and Validation of the Risk Evaluation Score for Pneumonia Involving Resistant Entities (RESPIRE) NCT07425561 | Azienda Ospedaliero-Universitaria Careggi | — |
| Completed | Effectiveness of Oral Management Strategies on Improving Oral Frailty and Oral Bacteria NCT05407532 | National Cheng-Kung University Hospital | N/A |
| Terminated | Pediatric Helmet CPAP Pilot Study NCT04764929 | Columbia University | N/A |
| Completed | Diagnostic Accuracy of Infection Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia NCT04652167 | University of Southern Denmark | — |
| Completed | The Effect of a Point-of-care Sputum Specimen Assay at the Emergency Department for Patients Suspected of Pneu NCT04651712 | University of Southern Denmark | N/A |
| Completed | Aerosolized Colistin to Mechanical Ventilated Patients With Pneumonia NCT04633317 | Chang Gung University | N/A |
| Completed | Enhancing Electronic Health Systems to Decrease the Burden of Colon Cancer, Lung Cancer, Obesity, Vaccine-Prev NCT04540081 | University of California, Davis | N/A |
| Completed | Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Patients With Hospital-acquir NCT03711331 | University Hospital, Lille | N/A |
| Active Not Recruiting | Discharge Stewardship in Children's Hospitals NCT05826873 | Children's Hospital of Philadelphia | N/A |
| Completed | PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT NCT04158804 | Massachusetts General Hospital | N/A |
| Completed | Determinants of COVID-19 Pneumonia (MC-19) NCT04387799 | Catholic University of the Sacred Heart | — |
| Unknown | Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized P NCT04229511 | SCARE (Study group for carbapenem resistance) | — |
| Completed | Influence of Pneumonia on Delayed Cerebral Ischemia After Subarachnoid Hemorrhage . SAH-CIP (SubArrachnoid Hem NCT05094349 | University Hospital, Brest | — |
| Completed | Pneumonia in the ImmunoCompromised - Use of the Karius Test for the Detection of Undiagnosed Pathogens NCT04047719 | Karius, Inc. | — |
| Completed | Impact of Pharmacist-led Educational Intervention on Pneumococcal Vaccination Rates in Cancer Patients NCT05229081 | Hacettepe University | N/A |
| Enrolling By Invitation | Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial NCT04178915 | The Republican Research and Practical Center for Epidemiology and Microbiology | — |
| Unknown | Sphingosine-1-phosphate and Pneumonia NCT04007328 | Taipei Medical University WanFang Hospital | Phase 2 / Phase 3 |
| Unknown | Relation Between the Volume of Subglottic Secretion and Risk of Extubation Failure in ICU Patients (SEGEX) NCT03946371 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia NCT03996967 | Boston University | — |
| Completed | A Single Ascending Dose Study in Adults (Stage 1) and Single Ascending Dose-Finding Study (Stage 2) in Elderly NCT03803202 | GlaxoSmithKline | Phase 1 / Phase 2 |
| Unknown | Search for Biomarkers of Infection and Inflammation in Patients With Acute Stroke. NCT03812666 | Jakob Ström | — |
| Completed | Evaluation of an Infant Immunization Encouragement Program in Nigeria NCT03870061 | GiveWell | N/A |
| Completed | Defining Antibiotic Treatment Duration for Ventilator - Associated Lung Infection NCT03382548 | University of Oxford | Phase 3 |
| Completed | Vaccination Education Through Pharmacists and Senior Centers (VEPSC) NCT03239665 | Rutgers, The State University of New Jersey | N/A |
| Completed | Phase I to Test a New Pneumococcal Vaccine NCT03303976 | LimmaTech Biologics AG | Phase 1 |
| Unknown | Development of Pneumonia Due to Alveolar Glucose Levels in Systemic Hyperglycemia NCT03577964 | University of Ulm | — |
| Completed | Evaluation the Association of Microbiome Between Respiratory Tract Samples and Stool Samples in Pneumonic Pati NCT03379779 | Taichung Veterans General Hospital | — |
| Completed | Urease Breath Test for Rapid Characterization of Pneumonia NCT03100760 | University of New Mexico | — |
| Unknown | Pneumonia Due to Stenotrophomonas Maltophilia in ICUs NCT03506191 | Groupe Hospitalier Pitie-Salpetriere | — |
| Recruiting | Fosfomycin I.v. for Treatment of Severely Infected Patients NCT02979951 | Infectopharm Arzneimittel GmbH | — |
| Unknown | Thermal Images on Smartphones to Diagnose Bacterial Pneumonia in Children in Pakistan NCT02908399 | Massachusetts General Hospital | N/A |
| Completed | Efficacy and Safety of Nemonoxacin vs Levofloxacin in Adult Patients With Community-Acquired Pneumonia NCT03551210 | R-Pharm | Phase 3 |
| Completed | Thermal Imaging of the Lung on a Smartphone to Differentiate Bacterial From Non Bacterial Causes of Pneumonia NCT02778672 | Boston University | — |
| Completed | CTTI Risk Factors for HABP/VABP Study NCT02689531 | Duke University | — |
| Completed | Modulation of Steroid Immunosuppression by Alveolar Efferocytosis NCT03034642 | VA Ann Arbor Healthcare System | N/A |
| Completed | A Study to Assess the Pharmacokinetic Profile, the Safety, and the Tolerability of ME1100 Inhalation Solution NCT02459158 | Meiji Seika Pharma Co., Ltd. | Phase 1 |
| Terminated | Systematic Search for Primary Immunodeficiency in Adults With Infections NCT02972281 | University Hospital, Lille | N/A |
| Completed | Use of Mobile Phones for Thermal Imaging of the Chest to Save Lives of Children With Pneumonia in Nagpur, Indi NCT02381431 | Massachusetts General Hospital | N/A |
| Completed | Procalcitonin in Early Antibiotic Interruption in Patient With Bacterial Pulmonary infeCtion and Acute Heart F NCT02787603 | University of Sao Paulo General Hospital | N/A |
| Completed | Thermal Imaging to Diagnose and Monitor Suspected Bacterial Infections NCT02292498 | Massachusetts General Hospital | N/A |
| Withdrawn | Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative and / or Gram-posit NCT02218359 | Cardeas Pharma | Phase 2 |
| Completed | Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia NCT01969799 | Cardeas Pharma | Phase 2 |
| Completed | Inhaled Amikacin Solution BAY41-6551 as Adjunctive Therapy in the Treatment of Gram-Negative Pneumonia NCT01799993 | Bayer | Phase 3 |
| Completed | Pharmacodynamic of Ceftaroline and Levofloxacin Against Pathogens Associated With Community Acquired Bacterial NCT01524302 | Gary E. Stein, Pharm.D. | Phase 4 |
| Unknown | Duration of Antibiotic Therapy in Community - Acquired Pneumonia NCT01492387 | University of Milan | Phase 4 |
| Completed | Five Versus Seven Day Antibiotic Course for the Treatment of Pneumonia in the Intensive Care Unit NCT01554657 | Washington University School of Medicine | N/A |
| Terminated | A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pn NCT01110421 | Janssen Research & Development, LLC | Phase 3 |
| Completed | The Study of Unasyn-S 12g/Day for Community Acquired Pneumonia (CAP) NCT01189487 | Pfizer | Phase 3 |
| Unknown | Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 NCT01747369 | Agence de Médecine Préventive, France | — |
| Completed | A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicat NCT01763008 | Janssen Pharmaceutica | — |
| Completed | A Study Of Intravenous Sulopenem And Oral PF-03709270 In Community Acquired Pneumonia That Requires Hospitaliz NCT00797108 | Pfizer | Phase 2 |
| Terminated | Study Evaluating Safety and Efficacy of Tigecycline Versus Imipenem/Cilastatin Subjects With Hospital-Acquired NCT00707239 | Pfizer | Phase 2 |
| Unknown | Intravenous Colistin Versus Intravenous Colistin Plus Nebulized Colistin in VAP Due MDR Acinetobacter Baumanni NCT00645723 | Hospitales Universitarios Virgen del Rocío | Phase 3 |
| Completed | Study Evaluating the Pharmacokinetics (PK), Safety, and Tolerability of Tigecycline in Patients 8 to 11 Years NCT00488345 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 2 |
| Completed | A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia NCT00515034 | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 2 |
| Completed | Outcomes of Patients Not Responding to Antibiotics in the Community NCT00245427 | CPL Associates | N/A |
| Withdrawn | Outpatient Registry Trial of Respiratory Tract Infections in Adults NCT00245453 | CPL Associates | Phase 4 |
| Completed | Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Child NCT00724828 | Wyeth is now a wholly owned subsidiary of Pfizer | — |
| Completed | A Study to Assess Beta-Lactam in the Treatment of Hospitalized Patients With Bacterial Pneumonia NCT00111644 | Hoffmann-La Roche | Phase 2 |
| Completed | Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acq NCT00540072 | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 3 |
| Completed | Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe C NCT00538694 | Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 3 |
| Completed | Effects of Hormone Therapy on the Immune Systems of Postmenopausal Women With Chronic Infections NCT00001890 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 |
| Completed | Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis NCT00406198 | Hopital Lariboisière | Phase 4 |