NCT03577964

Development of Pneumonia Due to Alveolar Glucose Levels in Systemic Hyperglycemia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 61 (actual)
• Sponsor: University of Ulm · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Incidence of Pneumonia in Patients with high systemic glucose levels.

Detailed description

Clinical and mechanistic studies have shown that a hyperglycaemic metabolic condition is associated with a higher incidence of infection and consecutive increased morbidity and mortality. The underlying mechanisms in detail are not completely understood. So far it is not clear whether systemic increased glucose levels are caused by a stress reaction of the body through a catabolic metabolism situation as well as a "stress-induced insulin resistance", or infections are promoted by hyperglycemia. From in vivo and in vitro studies, a glucose threshold for the lung is known (147 mg / dL), similar to that in the kidney. It can be hypothesized, that an intra-alveolar glucose in turn promotes bacterial growth as a nutrient substrate. The aim of the study is to determine the concentration of glucose in the alveolar space in connection with hyperglycemic conditions, and to demonstrate a higher incidence of pneumonia in this patient group. The study will enroll cardiac surgery patients receiving surgical treatment and expected postoperative ventilation. Systemic blood glucose monitoring is recorded throughout hospitalization, as well as the removal of bronchial aspirates intraoperatively and during ventilation to measure glucose levels and bacterial levels. The incidence of pneumonia is recorded during the postoperative period by means of radiological examinations and / or microbiological examinations.

Conditions

• Glucose Metabolism Disorders
• Pneumonia, Bacterial

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Glucose Measurements,	Measurement of glucose Levels in bronchio alveolar secretions

Timeline

• Start date: 2017-09-01
• Primary completion: 2019-04-25
• Completion: 2020-04-25
• First posted: 2018-07-05
• Last updated: 2019-04-26

Locations

1 site across 1 country: Germany