NCT03379779

Evaluation the Association of Microbiome Between Respiratory Tract Samples and Stool Samples in Pneumonic Patients Accompanied by Respiratory Failure

Department of Critical Care Medicine, Taichung Veterans General Hospital

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 200 (actual)
• Sponsor: Taichung Veterans General Hospital · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

A prospective observational study. Enrolled participants admitted to ICU due to pneumonia and respiratory failure need mechanical ventilator support. Investigators collected the residual specimens, such as sputum from endotrachea aspiration, bronchoalveolar lavage fluid in those participants as the usual care in the ICU. Those residual samples were sent to extract RNA and sequence by using high-throughput sequencing (next-generation sequencing) method. Investigators will compared the microbiome feature between lower respiratory tract and stool specimens in those participants diagnosed as pneumonia with respiratory failure.

Conditions

• Microbiota
• Pneumonia, Bacterial
• Respiratory Failure
• Lower Resp Tract Infection

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	16s RNA sequence of sputum, bronchoalveolar lavage fluid (options), stool	We will check the microbiome in lower respiratory samples (sputum and bronchoalveolar lavage fluid) and stool by using 16S RNA sequencing

Timeline

• Start date: 2017-08-28
• Primary completion: 2019-09-01
• Completion: 2019-09-01
• First posted: 2017-12-20
• Last updated: 2019-09-16

Locations

1 site across 1 country: Taiwan