| Recruiting | The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis NCT07537426 | The First Affiliated Hospital of Zhejiang Chinese Medical University | N/A |
| Recruiting | Effect of Acoltremon Ophthalmic Solution 0.003% on Signs and Symptoms of Ocular Surface Disease in Stage I Neu NCT07502378 | University of South Florida | Phase 4 |
| Not Yet Recruiting | This is a Single Center, Open-label Prospective Study to Evaluate the Effect of Xiidra® (Lifitegrast Ophthalmi NCT07490535 | Pittsburgh Research Institute | Phase 4 |
| Not Yet Recruiting | Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive® NCT06375343 | Laboratorios Sophia S.A de C.V. | Phase 1 |
| Not Yet Recruiting | Wide Field OCTA in Ocular Diseases NCT07298174 | IRCCS San Raffaele | — |
| Not Yet Recruiting | Efficacy and Safety of Oral Probiotics on Ocular Symptoms and Gut Microbiome of Children with Vernal Keratocon NCT06793514 | Mohsen Pourazizi | Phase 1 |
| Completed | Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery NCT07067294 | Grigore T. Popa University of Medicine and Pharmacy | N/A |
| Recruiting | Eyelid Closure in Keratometry NCT07297849 | Vienna Institute for Research in Ocular Surgery | N/A |
| Completed | The Effect of Eye Care With Artificial Tears and Normal Saline on Ocular Surface Disease in Mechanically Venti NCT07000565 | Marmara University | N/A |
| Not Yet Recruiting | Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefr NCT06624384 | Mohsen Pourazizi | Phase 1 |
| Completed | Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Femto-Lasik Surgery NCT07181668 | Grigore T. Popa University of Medicine and Pharmacy | N/A |
| Recruiting | Clinical Application Research of Scleral Lenses in Ocular Surface Diseases NCT06555367 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Recruiting | Investigator-initiated Clinical Trial to Observe Conjunctival Goblet Cell Using an Anterior Segment Imaging De NCT06427629 | Seoul National University Hospital | N/A |
| Completed | Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Of NCT06370585 | Laboratorios Sophia S.A de C.V. | Phase 1 |
| Recruiting | The Pattern of Dry Eye Disease After Cataract Surgery NCT06298890 | Lithuanian University of Health Sciences | — |
| Active Not Recruiting | A Comparative Study Between Preservative With Benzalkonium Chloride vs Preservative Free Eye Drops on the Ocul NCT06404541 | Kasr El Aini Hospital | Phase 4 |
| Active Not Recruiting | A Cross-sectional Study of Ocular Manifestations During the Covid-19 Pandemic in Hubei Province NCT06355128 | Zhongnan Hospital | — |
| Active Not Recruiting | Comparison Between Lathe Cut Versus Cast Molding Soft Contact Lens Technique on Ocular Surface Integrity NCT06495112 | Superior University | N/A |
| Completed | Effects of HFMH-EMS on Ocular Artery Circulation NCT06861985 | Chung Shan Medical University | N/A |
| Unknown | Croatian Version of the Ocular Surface Disease Index Questionnaire (OSDI) NCT05938985 | University Hospital Sestre Milosrdnice | — |
| Unknown | Evaluation of the Safety and Efficacy of Rigid Breathable Scleral Contact Lenses for the Correction of Ametrop NCT06256770 | Tianjin Eye Hospital | — |
| Completed | AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye NCT06013436 | Chengdu University of Traditional Chinese Medicine | — |
| Completed | Ocular Surface Disease and IOP Monitoring With Travoprost Without Conservatives NCT05319470 | Democritus University of Thrace | — |
| Completed | Cool vs Room-temperature Artificial Tears NCT05832996 | University of Iowa | Phase 4 |
| Unknown | Pediatric Eye Care Investigated Team NCT05247099 | Zhongshan Ophthalmic Center, Sun Yat-sen University | — |
| Unknown | Optic Nerve Diameter and Intraocular Pressure Changes in Patients Undergoing Vitrectomy Under General Anesthes NCT05195801 | Akdeniz University | — |
| Unknown | Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necro NCT05145959 | Massachusetts Eye and Ear Infirmary | N/A |
| Completed | Preservative-free Fixed-dose Combination of Tafluprost 0.0015% / Timolol 0.5% in Patients With Open-angle Glau NCT04828057 | Santen Pharmaceutical (Taiwan) Co., LTD | — |
| Completed | Novel Use of Cyclosporine Ophthalmic Emulsion 0.05% in a PROSE Device NCT04918823 | Boston Sight | Phase 1 / Phase 2 |
| Recruiting | Analysis of Videodermatoscopic Parameters of Ocular, Periocular, Conjunctival and Palpebral Neoformations NCT06714799 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Withdrawn | Novel Use of Restasis and PROSE Devices NCT04735510 | Boston Sight | Phase 3 |
| Completed | Short and Long-term Results of Skin Versus Skin Plus Orbicularis Resection Blepharoplasty NCT05528016 | Marmara University | N/A |
| Completed | Effect on Ocular Surface Symptoms of Online Education NCT04960696 | Kahramanmaras Sutcu Imam University | — |
| Recruiting | Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications NCT04354545 | University of California, Los Angeles | — |
| Completed | Cyclosporine 0.1% Eye Drops as Prophylactic Treatment In Cataract Surgery NCT04812951 | Campus Bio-Medico University | EARLY_Phase 1 |
| Completed | Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye NCT04493658 | Johns Hopkins University | — |
| Unknown | Platelet Rich Plasma Eye Drops for Treatment of Ocular Surface Disease NCT04608084 | University Health Network, Toronto | Phase 4 |
| Completed | Evaluation of Ocular Surface in Hemodialysis Patients by Ocular Surface Analyzer NCT04949295 | XiaoYong Liu | — |
| Unknown | Pre-Surgical Ocular Surface Treatment With Intracanalicular Dexamethasone Insert And Effect On Intraocular Len NCT04530864 | Prism Vision Group | Phase 4 |
| Completed | Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fittin NCT04649177 | Boston Sight | N/A |
| Completed | Effect of Four Different Diagnostic Eye Drops on Tear Film Thickness NCT07230548 | Medical University of Vienna | Phase 3 |
| Completed | The Effects of Androgen Replacement Therapy on Tear Osmolarity and Ocular Surface Parameters in Androgen Defic NCT07168265 | Neon Hospital | N/A |
| Completed | Effects of Topical Low Dose Preservative-free Hydrocortisone on Intraocular Pressure NCT04536129 | University of Molise | N/A |
| Completed | Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients NCT04351100 | Chulalongkorn University | — |
| Unknown | Impact of Prematurity on the Optic Nerve NCT04067973 | Nantes University Hospital | — |
| Completed | Meibomian Gland Dysfunction Management With ZEST Protocol NCT03968731 | University of the Incarnate Word | N/A |
| Completed | The Effect of Punctal Plugs on Ocular Surface After Povidone-Iodine Preparation of Intravitreal Injection NCT03945071 | University of Oklahoma | N/A |
| Unknown | Ocular Function in Autism Spectrum Disorder NCT04010422 | National Taiwan University Hospital | — |
| Completed | A Phase III Multinational Multicenter Investigator-Masked Randomized Active-Controlled Trial Comparing the Eff NCT04133311 | Santen SAS | Phase 3 |
| Completed | Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface NCT03923244 | University Hospital, Clermont-Ferrand | N/A |
| Completed | Corneal Epithelial Stem Cells and Dry Eye Disease NCT03302273 | Sloan W. Rush, MD | N/A |
| Terminated | Study of Brimonidine Tartrate Nanoemulsion Eye Drops in Patients With Ocular Graft-vs-Host Disease NCT03591874 | Ocugen | Phase 3 |
| Completed | A Phase I Study of PP-001 Eye Drops in Healthy Adult Volunteers NCT03769454 | Panoptes Pharma GmbH | Phase 1 |
| Completed | Outcome of Omega 3 FA and Punctal Plugs on Ocular Surface Disease NCT03686059 | Benha University | Phase 4 |
| Completed | From Preserved, to Preservative-free Cyclosporine 0.1% Enhanced Triple Glaucoma Therapy NCT04673604 | Aristotle University Of Thessaloniki | N/A |
| Completed | Ocular Surface Disease Changes After iStent or iStent Inject Implantation With Phacoemulsification NCT04452279 | Vance Thompson Vision | N/A |
| Completed | Autologous Blood Treatment for Ocular Surface Disease NCT03659955 | NHS Lanarkshire | N/A |
| Completed | Validation of a Newly Developed Liquid Jet Aesthesiometer NCT02999035 | University of Applied Sciences and Arts Northwestern Switzerland | — |
| Unknown | Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear NCT02894489 | National Taiwan University Hospital | N/A |
| Completed | Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease NCT03364322 | Hallym University Kangnam Sacred Heart Hospital | — |
| Completed | Amelioration of Adverse Ocular Side Effects of Glaucoma Medications in Glaucoma Patients Using Topical GL101 NCT02656394 | Glia, LLC | Phase 2 |
| Completed | 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy NCT02802137 | Aristotle University Of Thessaloniki | Phase 4 |
| Completed | LK Scleral Lens for Patients With Intractable Ocular Surface Diseases NCT04535388 | Seoul National University Hospital | N/A |
| Withdrawn | Omega 3 Supplementation and Ocular Surface Disease in Glaucoma NCT01630551 | University of Illinois at Chicago | N/A |
| Completed | Management of Eyelid Disorders by Ophthalmologists in Usual Medical Practice NCT01552174 | Laboratoires Thea | — |
| Unknown | Hydroxypropylmethylcellulose 0.3% and Sodium Hyaluronate 0.18% for Ocular Surface Disease in Glaucoma NCT01284439 | Mahidol University | N/A |
| Completed | Safety and Efficacy Study of Catioprost® (Unpreserved Latanoprost 0.005% Emulsion) Compared to Travatan Z® to NCT01254370 | Santen SAS | Phase 2 |
| Completed | Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome. NCT01178242 | Federal University of São Paulo | N/A |
| Unknown | Ocular Surface Reconstruction With Cultivated Autologus Mucosal Epithelial Transplantation NCT01942421 | Mahidol University | Phase 2 / Phase 3 |
| Completed | Assessing Ocular Surface Changes After Changing Glaucoma Medications NCT00554411 | University of Colorado, Denver | — |
| Suspended | Transplantation of Cultivated Limbal Epithelium on Amniotic Membrane for Limbal Stem Cell Deficiency NCT00348114 | Singapore National Eye Centre | Phase 2 |
| Completed | Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation NCT00346450 | Singapore National Eye Centre | Phase 3 |