NCT01942421

Ocular Surface Reconstruction With Cultivated Autologus Mucosal Epithelial Transplantation

Ocular Surface Reconstruction With Cultivated Autologus Mucosal Epithelial Transplantation.

• Status: Unknown
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to elucidate the appropriate condition of developing cultivated autologous oral mucosal epithelial graft and evaluate the surgical outcome of transplantation of the cultivated cells in the patients.

Detailed description

Ocular surface damage caused by severe ocular surface diseases. Corneal limbal stem cell transplantation has been demonstrated to improve the outcome of ocular surface reconstruction. However, the conventional management of allograft limbal transplantation generally has unsatisfactory outcome because of high risk of rejection and requires long-life immunosuppressive medications. Ocular surface reconstruction with cultivated autologous mucosal epithelial transplantation is served to improve the surgical results of ocular surface reconstruction and decrease the use of immunosuppressive medications

Conditions

• Ocular Surface Disease

Interventions

Type	Name	Description
PROCEDURE	Cultivated mucosal epithelial transplantation	cultivated autologous mucosal epithelium, then transplant to limbal stem cell deficiency patients.

Timeline

• Start date: 2008-01-01
• Primary completion: 2013-06-01
• Completion: 2013-12-01
• First posted: 2013-09-16
• Last updated: 2013-09-16

Locations

1 site across 1 country: Thailand