| Not Yet Recruiting | Preventive Dendritic Cell Vaccination for Lynch Syndrome NCT07412197 | Radboud University Medical Center | Phase 1 / Phase 2 |
| Not Yet Recruiting | Study Aiming to Test Whether Non-invasive Liquid Biopsies Can Safely Reduce Invasive Surveillance Methods in L NCT07360834 | UNICANCER | N/A |
| Not Yet Recruiting | Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer NCT07436312 | Gustave Roussy, Cancer Campus, Grand Paris | N/A |
| Not Yet Recruiting | Overcoming Barriers to Uptake of Cascade Screening NCT07304063 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | Evaluation of Capsule Colonoscopy in Patients With Lynch Syndrome NCT07445828 | Region Skane | — |
| Not Yet Recruiting | Determining the Prevalence of Muir-Torre Syndrome in Patients With Lynch Syndrome NCT07201012 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Recruiting | Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome NCT07220239 | Jessica D. St. Laurent, MD | N/A |
| Not Yet Recruiting | Clinical Validation of Sophia Genetics Assay NCT07160010 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Enrolling By Invitation | Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome NCT07106359 | University of Alabama at Birmingham | N/A |
| Recruiting | First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived NCT07163403 | Fundacion Clinic per a la Recerca Biomédica | Phase 1 |
| Recruiting | Assessing Uterine Cancer Risk in Lynch Syndrome Carriers Using Vaginal Self-sampling and a Health Questionnair NCT07194551 | University of British Columbia | N/A |
| Enrolling By Invitation | Patient Centered Clinical Decision Support for Hereditary Cancer Syndromes NCT06914726 | HealthPartners Institute | N/A |
| Not Yet Recruiting | Lynch Syndrome in Colorectal Cancer Surgery NCT06990633 | Izmir Ataturk Training and Research Hospital | — |
| Recruiting | Small Bowel Capsule Endoscopy in Lynch Syndrome NCT07472686 | Assistance Publique - Hôpitaux de Paris | — |
| Not Yet Recruiting | Predictive Value of PREMM5, MMRpredict, and Universal Tumor Screening for Lynch Syndrome in Vietnam NCT06863038 | University of Medicine and Pharmacy at Ho Chi Minh City | — |
| Not Yet Recruiting | DYNAMICS-LYNCH：DNA Methylation Analysis in Stool for Screening of Lynch Syndrome-Associated Colorectal Cancer NCT06772844 | Sun Yat-sen University | — |
| Enrolling By Invitation | The Yield of Artificial Intelligence (GI Genius) in Lynch Syndrome - A Randomized Tandem-colonoscopy Trial NCT06654128 | Sheba Medical Center | N/A |
| Recruiting | Lynch Syndrome Integrative Epidemiology and Genetics NCT06582914 | University of Colorado, Denver | — |
| Not Yet Recruiting | EC_ItaLynch: Mainstreaming the Diagnosis of Lynch Syndrome NCT06501417 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | PSYLIVED: the Psychological Impacts of Living With an Inherited Colorectal Cancer Predisposition Syndrome NCT06447961 | London North West Healthcare NHS Trust | — |
| Recruiting | CAD-EYE System for the Detection of Neoplastic Lesions in Patients With Lynch Syndrome NCT05963191 | PERROD Guillaume | N/A |
| Recruiting | Video Capsule Examination in Patients With Lynch Syndrome NCT06712095 | Royal Marsden NHS Foundation Trust | N/A |
| Completed | Colonoscopy Check-up in People With Lynch Syndrome NCT06126120 | Imperial College London | — |
| Recruiting | Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease NCT07450612 | San Raffaele University | — |
| Enrolling By Invitation | Strategy for Management of Patients With Hereditary Cancer Syndromes (HCS) in a Rural Environment NCT07381985 | University of Vermont Medical Center | N/A |
| Unknown | Perception About Benefits and Risks Related to Combined Hormonal Contraceptives Use in Patients With Lynch Syn NCT05909410 | Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia | — |
| Recruiting | Lynch Syndrome X-Talk of Enteral Mucosa With Immune System NCT06708429 | San Raffaele University | — |
| Active Not Recruiting | Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome NCT05419011 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention NCT05677048 | M.D. Anderson Cancer Center | N/A |
| Recruiting | Urothelial Cancer Screening in Individuals With Lynch Syndrome Using a Urine Tumor DNA Panel (LS-URO Study) NCT06218433 | Tampere University Hospital | N/A |
| Recruiting | A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule NCT07219537 | Massachusetts General Hospital | N/A |
| Recruiting | A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in NCT05411718 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | Scalable Communication Modalities for Returning Genetic Research Results NCT04407611 | Boston University | N/A |
| Active Not Recruiting | Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients NCT05078866 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Active Not Recruiting | The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics NCT05692596 | H. Lee Moffitt Cancer Center and Research Institute | — |
| Recruiting | Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients NCT06523582 | Universidad Nacional Autonoma de Mexico | — |
| Recruiting | Prospective Multicenter Registry Study to Assess the Frequency of Lynch Syndrome Among Patients With Colorecta NCT05495776 | State Scientific Centre of Coloproctology, Russian Federation | — |
| Unknown | Inherited Cancer Early Diagnosis (ICED) Study NCT06163365 | Royal Marsden NHS Foundation Trust | — |
| Recruiting | Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patient NCT05410977 | Mayo Clinic | — |
| Recruiting | Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome NCT04920149 | Ann-Sofie Backman | Phase 2 |
| Withdrawn | Evaluating the Cologuard Test for Use in Lynch Syndrome NCT04778566 | Geisinger Clinic | — |
| Unknown | Evaluation of ArTificial Intelligence System (Gi-Genius) for adenoMa dEtection in Lynch Syndrome. NCT04909671 | Hospital Clinic of Barcelona | N/A |
| Completed | Overcoming Barriers to the Uptake of Cascade Screening for Lynch Syndrome: Workbook Feasibility Study NCT04978350 | UNC Lineberger Comprehensive Cancer Center | N/A |
| Terminated | Tislelizumab for the Treatment of Recurrent Mismatch Repair Deficient Endometrial Cancer NCT04906382 | Floor Backes, MD | EARLY_Phase 1 |
| Unknown | Faecal Microbiota Characterization in Lynch Syndrome (LS) Patients With or Without Colorectal Neoplasia NCT04791644 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian NCT04508764 | Washington University School of Medicine | N/A |
| Unknown | DNA Adductomics for Colorectal Cancer Investigation NCT04865601 | University of Copenhagen | — |
| Withdrawn | Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and You NCT04500548 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Pediatric Reporting of Adult-Onset Genomic Results NCT03832985 | Geisinger Clinic | EARLY_Phase 1 |
| Unknown | PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients NCT04711434 | Sun Yat-sen University | Phase 3 |
| Completed | Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome NCT04452266 | University Hospital, Lille | — |
| Unknown | Family History Study on Cancer Risk NCT04145388 | Kaiser Permanente | N/A |
| Recruiting | Identifying and Caring for Individuals With Inherited Cancer Syndrome NCT04494945 | OHSU Knight Cancer Institute | N/A |
| Recruiting | Prostate Cancer Genetic Risk Evaluation and Screening Study NCT05129605 | Massachusetts General Hospital | — |
| Active Not Recruiting | Direct Information to At-risk Relatives NCT04197856 | Umeå University | N/A |
| Unknown | Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation NCT04516083 | RWJ Barnabas Health at Jersey City Medical Center | — |
| Completed | Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants NCT04131062 | Geisinger Clinic | N/A |
| Recruiting | Registry of Subjects at Risk of Pancreatic Cancer NCT04095195 | Associazione Italiana per lo Studio del Pancreas | — |
| Completed | Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome NCT05257057 | WellSpan Health | — |
| Unknown | Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE) NCT03831698 | University of Kansas Medical Center | Phase 2 |
| Unknown | MSI in Circulatory DNA of Endometrial Cancer NCT03744962 | Lei Li | — |
| Recruiting | Videocapsule Endoscopy in Lynch Syndrome NCT05704010 | San Raffaele University | N/A |
| Terminated | Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy NCT03631641 | John Hays | Phase 2 |
| Completed | Atorvastatin ± Aspirin in Lynch Syndrome Syndrome NCT04379999 | Fox Chase Cancer Center | EARLY_Phase 1 |
| Completed | Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care NCT03460483 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Linked Color Imaging Versus High-definition White Light Endoscopy for the Detection of Polyps in Patients With NCT03344289 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Active Not Recruiting | Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch S NCT02813824 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Active Not Recruiting | Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Def NCT02912559 | National Cancer Institute (NCI) | Phase 3 |
| Recruiting | Liquid Biopsy Evaluation and Repository Development at Princess Margaret NCT03702309 | University Health Network, Toronto | — |
| Recruiting | Familial Investigations of Childhood Cancer Predisposition NCT03050268 | St. Jude Children's Research Hospital | — |
| Recruiting | Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland NCT03124212 | University of Basel | — |
| Completed | Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Cri NCT03046849 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Completed | Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer NCT03047226 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Active Not Recruiting | Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrom NCT04125914 | M.D. Anderson Cancer Center | N/A |
| Completed | High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome. NCT02951390 | Hospital Clinic of Barcelona | N/A |
| Completed | NBI Versus Indigo Carmine During Colonoscopy in Lynch Syndrome NCT02570516 | Assistance Publique - Hôpitaux de Paris | N/A |
| Unknown | Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer NCT02494791 | University Health Network, Toronto | N/A |
| Active Not Recruiting | Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diff NCT02359565 | National Cancer Institute (NCI) | Phase 1 |
| Active Not Recruiting | Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Poly NCT02371135 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool NCT02645084 | Prof. Evelien Dekker, MD, PhD | N/A |
| Active Not Recruiting | Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Sy NCT02194387 | M.D. Anderson Cancer Center | N/A |
| Completed | Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes NCT02198092 | University of Pennsylvania | — |
| Active Not Recruiting | Pancreatic Cancer Early Detection Program NCT02206360 | White Plains Hospital | — |
| Unknown | Prostate Cancer Screening Among Men With High Risk Genetic Predisposition NCT02053805 | Rabin Medical Center | N/A |
| Completed | Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome NCT02052908 | National Cancer Institute (NCI) | Phase 1 |
| Recruiting | The Cancer of the Pancreas Screening-5 CAPS5)Study NCT02000089 | Johns Hopkins University | Phase 3 |
| Recruiting | Integrated Cancer Repository for Cancer Research NCT02012699 | University of Nebraska | — |
| Completed | Ohio Colorectal Cancer Prevention Initiative NCT01850654 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Molecular Screening for Lynch Syndrome in Denmark NCT01845753 | Vejle Hospital | — |
| Completed | Hereditary Colorectal and Associated Tumor Registry Study NCT00633607 | University of Pittsburgh | — |
| Completed | Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting NCT01582841 | Kaiser Permanente | N/A |
| Completed | I-Scan For Colon Polyp Detection In HNPCC NCT01823471 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Completed | Molecular Screening for Lynch Syndrome in Southern Denmark NCT01216930 | Vejle Hospital | — |
| Withdrawn | Biomarkers in Samples From Patients With Endometrial Cancer NCT01199250 | Gynecologic Oncology Group | — |
| Completed | Capsule Endoscopy to Screen for Small Bowel Neoplasia in Lynch Syndrome NCT00898768 | University Medical Center Groningen | EARLY_Phase 1 |
| Completed | Chromoendoscopy to Decrease the Risk of Colorectal Neoplasia in Lynch Syndrome NCT00905710 | University Medical Center Groningen | N/A |
| Completed | Telemedicine vs. Face-to-Face Cancer Genetic Counseling NCT00609505 | Duke University | N/A |
| Unknown | Familial Colorectal Cancer Registry in Hispanics NCT00927680 | University of Puerto Rico | — |
| Completed | Registry for Women Who Are At Risk Or May Have Lynch Syndrome NCT00508573 | M.D. Anderson Cancer Center | — |
| Recruiting | The GEOLynch Cohort Study NCT03303833 | Wageningen University | — |
| Active Not Recruiting | Multi-Organ Screening Recommendations in Patients With Lynch Syndrome NCT00582296 | Memorial Sloan Kettering Cancer Center | — |