NCT03046849

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer Patients Meeting Chinese Lynch Syndrome Criteria: An Open-label and Multi-center Study.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to find out the proportion of patients diagnosed with Lynch syndrome in colorectal cacner patients meeting Chinese Lynch syndrome criteria. Besides, this study is aimed to analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population.

Detailed description

1. Detect germline mutation (by next-generation squencing) in probands. 2. Verify the germline mutation in blood relatives whose proband has known germline mutation(s). 3. Analyze the test data with clinical and family information. Diagnose Lynch syndrome in the included population. 4. Analyze the clinical characteristics and germline mutation of Lynch syndrome in Chinese population.

Conditions

• Lynch Syndrome

Interventions

Type	Name	Description
OTHER	next-generation sequencing	Use next-generation sequencing to test germline mutation.

Timeline

• Start date: 2017-03-08
• Primary completion: 2019-02-26
• Completion: 2019-02-26
• First posted: 2017-02-08
• Last updated: 2021-08-11

Locations

3 sites across 1 country: China