| Not Yet Recruiting | Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder NCT06807918 | University of Pennsylvania | Phase 2 / Phase 3 |
| Recruiting | Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder NCT06559995 | University of Pennsylvania | Phase 2 / Phase 3 |
| Not Yet Recruiting | Ketogenic Metabolic Therapy in Schizophrenia, Bipolar Disorder, Major Depressive Disorder: Deep Omic Profiling NCT06748950 | Stanford University | N/A |
| Recruiting | Effects of Ketone Supplement and Alcohol on Brain Metabolism NCT06815237 | University of Pennsylvania | Phase 2 / Phase 3 |
| Completed | Exogenous Ketosis and Muscle Protein Synthesis During Exercise Recovery NCT06769100 | McGill University | N/A |
| Completed | The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young M NCT06683547 | McGill University | N/A |
| Recruiting | Effects of Exogenous Ketosis on Proteinuria and Renal Function NCT06867471 | Gødstrup Hospital | N/A |
| Completed | Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity NCT06418074 | Gødstrup Hospital | N/A |
| Completed | The Effect of Butanediol Ingestion on Skeletal Muscle Angiogenesis in Hypoxia NCT06472427 | KU Leuven | N/A |
| Completed | Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal F NCT06318299 | University of Aarhus | N/A |
| Recruiting | The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis NCT06338969 | The Society of Bariatric and Metabolic Surgeons of Kazakhstan | N/A |
| Enrolling By Invitation | Effects of Ketone Supplementation on Acute Alcohol Withdrawal NCT06173973 | University of Pennsylvania | Phase 2 / Phase 3 |
| Unknown | Intermittent Exogenous Ketosis (IEK) at High Altitude NCT06097754 | Jozef Stefan Institute | N/A |
| Completed | Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More NCT06053138 | Central Jutland Regional Hospital | N/A |
| Completed | Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subj NCT05980858 | Gødstrup Hospital | N/A |
| Unknown | Examining the Feasibility of Prolonged Ketone Concentrate Supplement Drink Consumption in Adults With Type 2 D NCT05983562 | University of British Columbia | N/A |
| Recruiting | Variations in Ketone Metabolism NCT05924295 | Ohio State University | N/A |
| Active Not Recruiting | Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies NCT05501366 | Ohio State University | N/A |
| Unknown | Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With R NCT04921293 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | N/A |
| Completed | Effect of Ketone Ester Supplementation on Sleep and Recovery in Hypoxia NCT06060093 | KU Leuven | N/A |
| Completed | Ketogenic Intervention in Depression NCT06080932 | Ohio State University | N/A |
| Unknown | Exogenous Ketosis in a Fed and a Fasted State NCT06320522 | University of Oxford | N/A |
| Completed | Metabolomic Signature of Exogenous Ketosis NCT05699707 | University of British Columbia | N/A |
| Completed | Pre-meals of 3-hydroxybutyrate in Type 2 Diabetes NCT05581043 | University of Aarhus | N/A |
| Completed | The Effects of Acute Ketone Monoester Supplementation on Exercise Efficiency and the Influence of Dose and Int NCT05665855 | McMaster University | N/A |
| Completed | Effect of Ketone Ester Supplementation on Hypoxic Tolerance NCT05588427 | KU Leuven | N/A |
| Unknown | Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers NCT05656339 | Federal University of Mato Grosso | N/A |
| Unknown | Examining the Feasibility of Prolonged Ketone Supplement Drink Consumption in Adults With Type 2 Diabetes NCT05477368 | University of British Columbia | N/A |
| Completed | The Effect of a Ketone Drink on Liver Glucose Production in People With Type 2 Diabetes NCT05518448 | University of Exeter | N/A |
| Completed | Ketogenic Diet Health and Longevity NCT05939011 | University of Kansas Medical Center | N/A |
| Completed | The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals NCT05273411 | University of British Columbia | N/A |
| Completed | Development of Ketoacidosis During the Perioperative Period: an Observational Study 'The DKAP Study' NCT05225467 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | The Effects of Acute Ketone Monoester Supplementation on 20-Minute Time-Trial Performance in Trained Cyclists NCT05226962 | McMaster University | N/A |
| Completed | Efficacy of Acute Intake of Ketones on Performance in Professional Road Cyclists NCT05294939 | Universidad Católica San Antonio de Murcia | N/A |
| Completed | MI-CBT Adherence Program for Lifestyle Interventions in Older Adults NCT04817176 | Florida State University | N/A |
| Completed | Time-Restricted Feeding NCT04884659 | Rockefeller University | N/A |
| Completed | Ketone Ester Supplementation on Neuro-cardiovascular Responses to Stress in Humans NCT04881526 | University of Guelph | N/A |
| Unknown | Effect of Exogenous Ketosis During Ultra-endurance Exercise NCT05407753 | KU Leuven | Phase 2 |
| Unknown | Exogenous Ketones for Acutely Decompensated HEart Failure NCT04698005 | Institute for Clinical and Experimental Medicine | Phase 3 |
| Unknown | Ketone Supplements and Substrate Oxidation and Physical Performance NCT04737694 | United States Army Research Institute of Environmental Medicine | N/A |
| Unknown | Weight-Adjusted Dosing of 3-OHB in Patients With Chronic Heart Failure NCT04594265 | University of Aarhus | Phase 2 |
| Unknown | Exogenous Ketone Supplementation and Cognitive Function During Exercise NCT04576026 | Western University, Canada | N/A |
| Completed | Ketones and Muscle Protein Synthesis NCT04565444 | McGill University | N/A |
| Unknown | Does a Ketogenic Dietary Supplement Reduce Alcohol Withdrawal Symptoms in Humans? NCT03878225 | Anders Fink-Jensen, MD, DMSci | N/A |
| Completed | Exogenous Ketones in Type 2 Diabetes NCT04194450 | University of British Columbia | N/A |
| Unknown | Markers of Appetite Regulation During Exogenous Ketosis NCT04156477 | Central Jutland Regional Hospital | N/A |
| Completed | Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status NCT04130724 | Readout, Inc. | — |
| Completed | The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune R NCT05558488 | Katarzyna Siedzik | N/A |
| Completed | Effect of Ketone Esters in Parkinson's Disease NCT04477161 | University of Florida | N/A |
| Unknown | Ketone Supplementation and Exercise Performance NCT03954665 | Western University, Canada | N/A |
| Unknown | Ketone Supplementation, Glycogen Replenishment and Time Trial Performance Following Glycogen Lowering Exercise NCT04004676 | Western University, Canada | N/A |
| Completed | Metabolic Differences of an Oral and Intravenous Dose of 3-hydroxybutyrate (3-OHB). NCT03935841 | University of Aarhus | N/A |
| Unknown | Exogenous Ketone Supplementation and Exercise Performance NCT03895892 | Western University, Canada | N/A |
| Unknown | Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Chronic Heart Failure: NCT04443426 | University of Aarhus | Phase 2 |
| Completed | Market Research - Acceptability Study for New MCT Fat Products NCT04309214 | Dr. Schär AG / SPA | N/A |
| Completed | Market Research - Acceptability Study for a Range of MCT Products NCT04309149 | Dr. Schär AG / SPA | N/A |
| Terminated | Betaquik as an Adjunct to Dietary Management of Epilepsy in Adults on the Modified Atkins Diet NCT03790436 | University of Southern California | N/A |
| Unknown | Ketone Esters for Optimization of Cognitive Performance in Hypoxia NCT03659825 | HVMN Inc | N/A |
| Withdrawn | Oral Glucose Intervention for Children With Gastroenteritis and Ketosis NCT02729870 | University of Florida | — |
| Completed | Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females NCT04744142 | KU Leuven | N/A |
| Completed | Comparison Between Breath Acetone and Blood Beta-Hydroxybutyrate NCT03299543 | Medamonitor | — |
| Unknown | Does a Ketogenic Diet Causes Ketosis in Patients on Intensive Care? NCT02763553 | University Hospitals Bristol and Weston NHS Foundation Trust | Phase 2 |
| Unknown | Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity NCT03564002 | University Of Perugia | — |
| Unknown | Ketone Supplementation in Individuals With PTSD NCT04083352 | Augusta University | N/A |
| Completed | Enhanced vs. Routine Clear Liquid Intake in Labor NCT02524002 | Temple University | N/A |
| Completed | A Trial of Intravenous Fluids During Labor NCT01110005 | Milton S. Hershey Medical Center | N/A |