NCT03895892

Exogenous Ketone Supplementation and Exercise Performance

The Effect of Exogenous Ketone Supplementation on 20 km Time Trial and Wingate Performance in Recreationally Active Individuals

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Western University, Canada · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

20 healthy recreationally active men and woman aged 18-35 will participate in the study. There will be three treatments involved: Caffeinated ketone supplements, non-caffeinated ketone supplement and water-placebo. Participants will complete the protocol three times and the treatment order will be systematically rotated to avoid any order effect. The three main trials will be separated by at least 1 week. After providing the corresponding treatment, participants will be given 30 minutes and after, they will perform a standardized 10-minute warm-up, followed by the 20 km time trial and a 30-second all-out Wingate test.

Detailed description

Some researchers support that a state of ketosis, reached through the use of ketogenic diet, has the potential to improve athletic. To attain such state, individuals must restrict carbohydrate intake to a maximum of 50g/ day or 10% while keeping protein intake moderate. One of the biggest challenges to achieve and maintain ketosis is complying with the diet due to its restrictive nature. Consequently, manufacturers have developed supplements that can induce a state of ketosis acutely (\~1 hour). Unfortunately, there is very little evidence supporting the use of these supplements to enhance athletic performance. Hyperketonemia (blood ketone concentration \> 0.2 Mm) seems to elevate the rate of utilization of ketone bodies. These changes in substrate utilization may allow athletes to preserve, something that would be advantageous for exercise performance. Ketone salts have been shown to elevate the concentration of ketones in blood and as such they may allow the body benefit from the apparent sparing of carbohydrates. Manufacturers now provide ketones salts combined with other ingredients such as caffeine. However it is unknown whether or not the addition of these ingredients has any positive or negative effect on athletic performance. Caffeine alone has been shown to improve athletic performance in several studies. Therefore, the purpose of this study is to compare the effectiveness of a caffeine free ketone salt supplement vs a caffeinated ketone salt supplement and their effects on a 20km time trial and a 30 second all-out Wingate test.

Conditions

• Ketonemia
• Ketosis

Interventions

Type	Name	Description
BEHAVIORAL	20 km time trial	20 km time trial cycling test will be conducted to measure the effect of different drinks on time
BEHAVIORAL	Wingate test	30 second all-out effort on a bike will be conducted to measure the effect of different drinks on peak power output
DIETARY_SUPPLEMENT	Ketone/Caffeine	Dietary supplement containing ketone salts and caffeine
DIETARY_SUPPLEMENT	Ketone	Dietary supplement containing only ketone salts
DIETARY_SUPPLEMENT	Water Placebo	Dietary supplement containing only water

Timeline

• Start date: 2019-05-15
• Primary completion: 2019-12-01
• Completion: 2019-12-01
• First posted: 2019-03-29
• Last updated: 2019-10-02

Locations

1 site across 1 country: Canada