NCT05273411

The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals

The Effect of Different Ketone Supplements on Blood Beta-hydroxybutyrate (β-OHB) and Blood Glucose in Healthy Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, there are different types of ketone supplements that differ in how they are metabolized in the body. Little is known about how these supplements affect blood ketone and blood glucose levels. The main objective of this study is to determine the effect of three different ketone supplements on blood ketones and blood glucose. The results of this pilot study will be used to guide future research for larger and more extensive studies on ketone supplements.

Conditions

• Ketosis
• Blood Glucose

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	(R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester	Single-dose pharmacokinetic study over 4 hours.
DIETARY_SUPPLEMENT	Beta-hydroxybutyric acid	Beta-hydroxybutyric acid
DIETARY_SUPPLEMENT	1,3-Butanediol	1,3-Butanediol

Timeline

• Start date: 2022-03-24
• Primary completion: 2022-05-18
• Completion: 2022-05-18
• First posted: 2022-03-10
• Last updated: 2024-08-01
• Results posted: 2024-08-01

Locations

1 site across 1 country: Canada