NCT04576026

Exogenous Ketone Supplementation and Cognitive Function During Exercise

Effect of Exogenous Ketone Supplementation on Cognitive Function During Exercise After Induced Mental Fatigue

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: Western University, Canada · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

15 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Ketone esters supplementation and iso-caloric carbohydrate. The purpose of this study is to evaluate the effect of ketone esters on cognitive function during exercise after induced mental fatigue

Detailed description

mental fatigue is often seen in sports of moderate to long duration. its onset is associated with detriments in cognitive function which leads to poor decision making and detriments in specific sport skills. Ketones can serve as a powerful brain fuel source so they may have the potential to delay/ revert the onset of mental fatigue. in this experiment, we will induce mental fatigue in individuals who will be performing 45 minutes of intermittent exercise right after. During exercise cognitive function will be measured under 2 condition, Ketone supplementation and placebo. The purpose of this study is to see if ketones can play a role in reverting that initial mental fatigue during exercise, compared to placebo.

Conditions

• Ketonemia
• Mental Fatigue
• Ketosis

Interventions

Type	Name	Description
BEHAVIORAL	mental fatiguing task	a 30-minute computerized Stroop test will be used to induce mental fatigue before exercise intervention
BEHAVIORAL	45 - minute simulated soccer game	an intermittent running protocol using intensities and speeds seen in soccer will be used to simulate the physiological demands of the sport
BEHAVIORAL	cognitive function	The Stroop test and a complex reaction time test will be used to assess cognitive function during exercise.

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-10-01
• Completion: 2021-10-01
• First posted: 2020-10-05
• Last updated: 2020-10-05

Locations

1 site across 1 country: Canada