NCT03954665

Ketone Supplementation and Exercise Performance

Can Ketone Supplementation Enhance Exercise Performance?

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Western University, Canada · Academic / Other
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).

Detailed description

Some believe very high fat diets (\>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (\>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to \~15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests.

Conditions

• Ketosis
• Exercise Performance
• Ketoses, Metabolic

Interventions

Type	Name	Description
BEHAVIORAL	10 km time trial	10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time
BEHAVIORAL	30s Wingate	30s all-out test to measure peak power output
DIETARY_SUPPLEMENT	Ketone	Supplement containing exogenous ketone salts
BEHAVIORAL	Baseline 10 km time trial	A baseline 10 km Cycling time trial test will be conducted
BEHAVIORAL	Baseline 30s Wingate	A baseline 30s all-out test to measure peak power output

Timeline

• Start date: 2019-09-01
• Primary completion: 2020-01-01
• Completion: 2020-03-01
• First posted: 2019-05-17
• Last updated: 2019-07-23

Locations

1 site across 1 country: Canada