NCT05939011

Ketogenic Diet Health and Longevity

Pilot Investigation of the Ketogenic Diet's Health Effects Through Multi-Omics Assessment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Kansas Medical Center · Academic / Other
• Sex: All
• Age: 30 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The goal of this pilot intervention is to learn about how a well-formulated ketogenic diet (WFKD) impacts various health factors in generally healthy adults. The main questions it aims to answer are: * Establish whether an 8-week isocaloric, WFKD improves body composition and metabolic biomarkers in adults without chronic disease. * Examine changes in transcriptomic sequencing pathways pre- and post-WFKD intervention. * Explore gut microbial changes in adults without chronic disease that consume a WFKD. Participants will follow a well-formulated ketogenic diet for 8-weeks. Study procedures include: * Weekly body weight tracking * Daily urinary ketone assessment * Pre/post stool samples for gut microbiota analyses * Pre/post DXA scans * Diet quality tracking through 3-day food records

Conditions

• Ketogenic Dieting
• Ketoses, Metabolic
• Ketosis

Interventions

Type	Name	Description
BEHAVIORAL	Well-formulated Ketogenic Diet	1:1 ketogenic diet that is focused on intake of high-quality fats (nuts/seeds, fatty fish, avocado) and reduction in processed food.

Timeline

• Start date: 2022-04-08
• Primary completion: 2023-09-15
• Completion: 2023-09-15
• First posted: 2023-07-11
• Last updated: 2023-11-28

Locations

1 site across 1 country: United States