NCT04194450

Exogenous Ketones in Type 2 Diabetes

The Effect of Acute Exogenous Oral Ketone Supplementation on Blood Glucose Levels in Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 20 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

Exogenous ketone supplements are proposed to have glucose-lowering potential, provide an alternative fuel for the brain and to enhance cognitive function. No studies have tested whether exogenous ketones can lower blood glucose in people with type 2 diabetes. In addition, the impact of exogenous ketones on brain blood flow, cognitive function or brain-derived neurotrophic factor in humans is unknown. The purpose of this study is to determine if acutely ingesting exogenous ketones, in the form of a ketone monoester drink, can lower glucose and improve measures of brain/cognitive function in humans with type 2 diabetes. Participants will consume a ketone monoester drink or placebo with blood samples, brain blood flow, and cognitive function assessed over 180 minutes. The researchers will also test how the ketone monoester drink impacts appetite and measures of inflammation.

Conditions

• Ketosis
• Type 2 Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone monoester	Acute ingestion of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate prior to assessment of outcomes.
DIETARY_SUPPLEMENT	Placebo	Acute ingestion of taste-matched placebo prior to assessment of outcomes.

Timeline

• Start date: 2020-01-15
• Primary completion: 2022-05-20
• Completion: 2022-05-20
• First posted: 2019-12-11
• Last updated: 2025-05-30
• Results posted: 2023-12-11

Locations

1 site across 1 country: Canada