| Not Yet Recruiting | Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion NCT06369350 | Milton S. Hershey Medical Center | EARLY_Phase 1 |
| Recruiting | DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes NCT07263347 | Hubei Cancer Hospital | — |
| Not Yet Recruiting | A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Fun NCT06582485 | iCoat Medical AB | Phase 2 / Phase 3 |
| Recruiting | A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney I NCT07164833 | Bilix Co.,Ltd. | Phase 2 |
| Recruiting | Hypertonic Lactate After Cardiac Arrest NCT05004610 | Erasme University Hospital | Phase 2 |
| Not Yet Recruiting | Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage. NCT06523920 | University of Cagliari | N/A |
| Recruiting | Safety and Efficacy of Remote Ischemic Conditioning for Patients Taking Off-pump Coronary Artery Bypass Grafti NCT06141525 | First Affiliated Hospital Xi'an Jiaotong University | N/A |
| Completed | A Study to Evaluate the Safety and Pharmacokinetics of BX-001N in Healthy Participants NCT06097702 | Bilix Co.,Ltd. | Phase 1 |
| Recruiting | Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries. NCT06895798 | Beijing Tsinghua Chang Gung Hospital | — |
| Unknown | Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery NCT05327348 | University of Malaya | Phase 3 |
| Completed | Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Ope NCT05598177 | Affiliated Hospital of Nantong University | Phase 4 |
| Unknown | Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury NCT05585255 | Nanfang Hospital, Southern Medical University | — |
| Recruiting | Auricular Vagus Stimulation and STEMI NCT05992259 | Bakulev Scientific Center of Cardiovascular Surgery | N/A |
| Completed | Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study. NCT05215743 | University of Chile | Phase 1 |
| Completed | FIH Phase I/IIa Trial Evaluating Safety of TUM012 to Minimize Ischemic Reperfusion Injury in Kidney Transplant NCT05246618 | iCoat Medical AB | Phase 1 / Phase 2 |
| Recruiting | Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys NCT05430620 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Phase 3 |
| Withdrawn | Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients NCT04531592 | Westat | Phase 2 |
| Withdrawn | Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Trauma Patients NCT04531579 | Westat | Phase 2 |
| Recruiting | NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial NCT04750616 | Kaiser Permanente | Phase 2 |
| Completed | Non-invasive Remote Ischemic PreConditioning (RIPC) in Free Flaps for Breast Reconstruction NCT07487220 | Ruhr University of Bochum | N/A |
| Unknown | Remote Ischemic Preconditioning in Cardiac Surgery NCT04647370 | Assiut University | N/A |
| Unknown | Pneumoperitoneum Preconditioning for the Prevention of Renal Function After Laparoscopic Partial Nephrectomy NCT03822338 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Recruiting | Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transpl NCT04005469 | Rhode Island Hospital | Phase 1 / Phase 2 |
| Recruiting | OSA as a Remote Ischemic Preconditioning in Vascular Surgery NCT04630535 | St. Anne's University Hospital Brno, Czech Republic | — |
| Completed | Intracoronary Administration of Glucocorticoids as a Treatment Method for No-Glucocorticoid Treatment for No-R NCT06552442 | Amosov National Institute of Cardiovascular Surgery | Phase 2 |
| Withdrawn | Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Pr NCT04388761 | Tambi Jarmi | Phase 1 |
| Unknown | Functional and Metabolic Effects of Ketone Bodies on Human Atrial Tissue in Patients With and Without Heart Fa NCT04379934 | University of Aarhus | N/A |
| Withdrawn | The Effect of Remote Ischemic Preconditioning on Ischemia/Reperfusion Injury in a Liver Transplant Recipient NCT03758352 | Rigshospitalet, Denmark | N/A |
| Completed | Dexmedetomidine on Tourniquet Induced -Systemic Effects NCT04307290 | Wonkwang University Hospital | Phase 4 |
| Completed | Role of Oxidative Stress in Ovarian Tissue After CO2-pneumoperitoneum Application-induced I/R NCT04493983 | Ismet Hortu | N/A |
| Not Yet Recruiting | Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation NCT03946852 | London Health Sciences Centre | N/A |
| Completed | Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery. NCT03772054 | University of Chile | N/A |
| Completed | Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response. NCT03743584 | Oslo University Hospital | N/A |
| Completed | The Effect of Pregabalin Given Preoperatively on the Tourniquet Induced Ischemia-reperfusion NCT03482544 | Baskent University | Phase 4 |
| Completed | Tongue Depressor-related Ischemia-Reperfusion Injury in Tongue NCT04205253 | Selcuk University | — |
| Unknown | Remote Ischemic Conditioning Using the autoRIC NCT03318575 | CellAegis US, Inc. | N/A |
| Active Not Recruiting | Intravenous Estrogen in Kidney Transplant Study NCT03663543 | University of Pennsylvania | Phase 1 / Phase 2 |
| Completed | The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy NCT03386435 | Asan Medical Center | N/A |
| Completed | Effects of Dexmedetomidine on the Liver Injury After Hepatectomy NCT02833688 | Chinese PLA General Hospital | Phase 4 |
| Completed | The Del Nido Versus Cold Blood Cardioplegia in Aortic Valve Replacement NCT03818126 | Pawel Buszman | N/A |
| Completed | Desflurane Preconditioning in Hepatectomies NCT03848780 | Aristotle University Of Thessaloniki | N/A |
| Completed | Immune Modulation by Ischemic Pre-conditioning in Healthy Individuals: Intracellular Signalling in Regulatory NCT03541239 | University of Aarhus | N/A |
| Unknown | Intermittent Portal and Graft Purge in Living Donor Liver Transplantation NCT02845154 | Mansoura University | N/A |
| Unknown | The Renal Transplant Outcome Prediction and Validation Study NCT03978065 | Medical University Innsbruck | N/A |
| Completed | Intrahepatic Blood Flow Occlusion and Cardiac Injury Risk in Partial Hepatectomy NCT06753461 | Beijing Tsinghua Chang Gung Hospital | — |
| Completed | The Effect of EPLerenone on Ischemia Reperfusion Injury in Human myoCARDium NCT02118753 | Radboud University Medical Center | N/A |
| Completed | Perioperative Time Course of MMP-9 and Its Inhibitor During Carotid Artery Stenting and Carotid Endarterectomy NCT03410576 | University of Pecs | — |
| Completed | Microcirculation and Anesthesia in Vascular Surgery NCT03510793 | Università Politecnica delle Marche | — |
| Completed | The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction NCT01172171 | Herlev Hospital | Phase 2 |
| Completed | Pediatric Remote Ischemic Pre-conditioning Prior to Complex Cardiac Surgery NCT01739088 | University of Alberta | N/A |
| Completed | Purge Vs no Purge in Living Donor Liver Transplantation Recipients NCT02540447 | Mansoura University | N/A |
| Completed | Safety and Efficacy of Treprostinil in Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplantati NCT01481974 | Abhinav Humar, MD | Phase 1 |
| Terminated | Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal Artery NCT01755858 | Stealth BioTherapeutics Inc. | Phase 1 / Phase 2 |
| Completed | Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Sur NCT04284592 | José García de la Asunción | N/A |
| Completed | The Metformin-FMD Trial NCT01610401 | Radboud University Medical Center | Phase 4 |
| Completed | Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Dono NCT01430156 | University of Edinburgh | Phase 3 |
| Completed | Perioperative Evaluation of MMP-9-TIMP-1 System in Vascular Surgery Regarding Ischemic-reperfusion Injury NCT03397732 | University of Pecs | — |
| Completed | Ischemia-reperfusion Injury Model on Healthy Volunteers and Measurement of Oxidative and Inflammatory Markers NCT01486212 | Herlev Hospital | — |
| Terminated | TOP-Study (Tacrolimus Organ Perfusion): Treatment of Ischemia Reperfusion Injury in Marginal Organs With an ex NCT01564095 | Ludwig-Maximilians - University of Munich | Phase 2 / Phase 3 |
| Unknown | Thymoglobulin Induction in Kidney Transplant Recipients NCT01239563 | University of Oxford | Phase 3 |
| Completed | The Safety of Vardenafil in Patients Undergoing Cardiac Surgery NCT01260285 | McGuire Research Institute | Phase 1 |
| Unknown | Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model NCT00691613 | University Medical Center Groningen | N/A |
| Terminated | Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transpla NCT00948194 | University of Colorado, Denver | N/A |
| Completed | Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury NCT00987974 | Radboud University Medical Center | Phase 4 |
| Unknown | Heme Arginate in Functional Magnetic Resonance Imaging (fMRI) NCT01461512 | MWolzt | Phase 2 |
| Withdrawn | Role of Intraoperative Thymoglobulin in Decreasing Ischemia-Reperfusion Injury in Pediatric Heart Transplant R NCT00709293 | University of California, Los Angeles | N/A |
| Unknown | YSPSL for Prevention of Ischemic Reperfusion Injury in Patients Undergoing Cadaveric Orthotopic Liver Transpla NCT00876902 | Y's Therapeutics, Inc. | Phase 2 |
| Completed | Gut Oxygenation and Laparoscopy NCT01040013 | University of Milano Bicocca | Phase 2 |
| Completed | Tacrolimus During the Implantation and the Effect on Ischemia-reperfusion Injury in Liver Transplantation NCT00609388 | Medical University of Vienna | Phase 4 |
| Withdrawn | Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise NCT00441714 | Radboud University Medical Center | N/A |
| Unknown | The Effects of Post-Conditioning and Administration of Vitamin C on Intramuscular High Energy Phosphate Levels NCT00534924 | Medical University of Vienna | N/A |
| Completed | Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury? NCT00457652 | Radboud University Medical Center | Phase 4 |
| Completed | Does a Seven Day Treatment With Dipyridamole Induce Protection Against Ischemia-Reperfusion Injury? NCT00457405 | Radboud University Medical Center | Phase 4 |
| Completed | The Effect of Rosiglitazone on Ischemia-reperfusion-injury Using Annexin A5 Scintigraphy. NCT00405015 | Radboud University Medical Center | Phase 2 |
| Completed | Does Atorvastatin Reduce Ischemia-Reperfusion Injury in Humans in-Vivo? NCT00441597 | Radboud University Medical Center | Phase 4 |
| Completed | Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury? NCT00430170 | Radboud University Medical Center | Phase 4 |
| Completed | Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation NCT00248040 | Dompé Farmaceutici S.p.A | Phase 2 |
| Completed | Repertaxin in Prevention of Primary Graft Dysfunction After Lung Transplantation NCT00224406 | Dompé Farmaceutici S.p.A | Phase 2 |
| Completed | Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation NCT01073202 | Shanghai Jiao Tong University School of Medicine | N/A |
| Unknown | The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery NCT00796588 | Royal Free Hampstead NHS Trust | N/A |
| Suspended | Adenosine Receptors Influence Ischemia-Reperfusion Injury NCT00184847 | Radboud University Medical Center | N/A |
| Unknown | Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion NCT00526695 | University of Zurich | Phase 4 |
| Suspended | Opioid Receptors Influence Ischemia-Reperfusion Injury NCT00184938 | Radboud University Medical Center | N/A |
| Completed | Ischemic Injury and Ischemic Preconditioning in Diabetes NCT00184821 | Radboud University Medical Center | — |
| Completed | The Effect of Caffeine on Ischemic Preconditioning NCT00184912 | Radboud University Medical Center | N/A |
| Terminated | Inhaled Nitric Oxide in Prevention/Treatment of Ischemia-Reperfusion Lung Injury Related to Lung Transplantati NCT00060450 | Mallinckrodt | Phase 3 |