NCT00526695

Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: Male
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Detailed description

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations. Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Conditions

• Ischemia/Reperfusion Injury

Interventions

Type	Name	Description
DRUG	Sevoflurane (Preconditioning)	Inhalation of sub-anesthetic doses of sevoflurane

Timeline

• Start date: 2005-01-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2007-09-10
• Last updated: 2008-07-18

Locations

1 site across 1 country: Switzerland