NCT00184912

The Effect of Caffeine on Ischemic Preconditioning

Caffeine Reduces Acute Ischemic Preconditioning

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (planned)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor antagonist already at concentrations reached after regular coffee consumption, we aimed to assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle. 24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes) or saline before a protocol for IP.

Conditions

• Caffeine
• Ischemic Preconditioning
• Ischemia-Reperfusion Injury

Interventions

Type	Name	Description
DRUG	caffeine
DRUG	Technetium-TC99m-labeled Annexin A5
PROCEDURE	ten minutes forearm ischemia
PROCEDURE	ischemic forearm exercise

Timeline

• Start date: 2003-09-01
• Completion: 2006-01-01
• First posted: 2005-09-16
• Last updated: 2006-11-29

Locations

1 site across 1 country: Netherlands