| Not Yet Recruiting | Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing Gener NCT07536568 | Cairo University | N/A |
| Not Yet Recruiting | Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support NCT07456670 | Queen's University | Phase 2 |
| Not Yet Recruiting | Caffeine Strategies and Fat Oxidation NCT07402902 | Universidad Rey Juan Carlos | N/A |
| Active Not Recruiting | Effects of Caffeine Ingestion on Morning Cognitive and 4-km Time Trial Performance in Males NCT07469852 | Liverpool John Moores University | Phase 1 / Phase 2 |
| Recruiting | Effects of Variations in Caffeinated Beverages on Well-being NCT07404254 | GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC. | N/A |
| Enrolling By Invitation | Effects of Caffeine Ingestion on Morning Cognitive and Muscle Repeated Sprint Performance in Males NCT07466732 | Liverpool John Moores University | EARLY_Phase 1 |
| Recruiting | Effects of Caffeinated Beverages on Well-being NCT07357818 | GUAYAKI SUSTAINABLE RAINFOREST PRODUCTS, INC. | N/A |
| Not Yet Recruiting | The Effects of Caffeine on Exercise Physiology and Time-trial Performance in a Hot Environment NCT07129200 | St. Mary's University, Twickenham | N/A |
| Completed | Oral Caffeine and Spinal-Induced Hypotension NCT07076654 | Cairo University | N/A |
| Not Yet Recruiting | The Repeatability of the Effect of Caffeine Supplementation on Submaximal Physiological Responses and Cycling NCT06935214 | St. Mary's University, Twickenham | N/A |
| Completed | 5 vs 10-Minute Chewing of Caffeinated Gum: Plasma Caffeine Pharmacokinetics NCT07386899 | Ege University | N/A |
| Completed | Effect of Low-Dose Caffeine on Performance in Elite Sitting Volleyball Players NCT07056231 | Ulaç Can YILDIRIM | N/A |
| Not Yet Recruiting | Investigating the Acute and Chronic Effects of a Supplement Containing Caffeine, Vitamins, Minerals and Botani NCT06780774 | Northumbria University | N/A |
| Completed | Caffeine and Sport Climbing Performance NCT07333443 | University of Alcala | N/A |
| Completed | Caffeinated Chewing Gum on Special Forces Performance NCT06638372 | National Taiwan Sport University | N/A |
| Completed | The Effect of Turkish Coffee on Postural Control and Hand-eye Coordination in Young Adults NCT06561113 | Bezmialem Vakif University | N/A |
| Completed | Acute Effects of Beetroot Juice and Caffeine Co-ingestion on Lower-limb Strength and Muscular Endurance in Fem NCT06758323 | Jose Manuel Jurado Castro | N/A |
| Completed | Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine NCT06441695 | Applied Science & Performance Institute | N/A |
| Completed | Caffeinated Chewing Gum & Wrestling Performance NCT06758336 | National Taiwan Sport University | N/A |
| Withdrawn | PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia NCT05295784 | University of Arkansas | Phase 1 |
| Completed | Caffeinated Chewing Gum on 400-meter Performance NCT06430996 | Chih-Hui Chiu | N/A |
| Completed | Caffeine & Bodybuilding Dehydration Ability NCT06431035 | Chih-Hui Chiu | N/A |
| Completed | Caffeinate Chewing Gum on Ice Hockey Performance NCT06557655 | National Taiwan Sport University | N/A |
| Unknown | Caffeine and Training Intensity Quantification NCT06210984 | St. Mary's University, Twickenham | N/A |
| Unknown | Motivational, Affective and Performance Effects of Caffeine Supplementation NCT06321861 | Jagiellonian University | N/A |
| Unknown | Baby-CINO: CaffeINe Treatment Optimisation in Premature Infants NCT06416956 | University of Oxford | — |
| Completed | The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function. NCT06602921 | Loughborough University | N/A |
| Completed | Effects of Caffeine Ingestion on the Biomechanics of Healthy Young Subjects NCT06039358 | University of Vic - Central University of Catalonia | N/A |
| Completed | The Turkish Version Of The Brief-Caffeine Expectancy Questionnaire NCT06038903 | Eskisehir Technical University | — |
| Completed | Caffeine, Resistance Exercise and EMG NCT06606652 | University of Alcala | N/A |
| Completed | Effect of Acute Caffeine and Beetroot Juice Intake on Strength, Power, and Muscular Endurance NCT06596395 | University of Alcala | N/A |
| Completed | Effects Of Caffeine On Cognitive Performance NCT05995314 | University of Castilla-La Mancha | N/A |
| Completed | Effects of Caffeinated Gum on a Basketball-specific Tests in Basketball Players NCT06016985 | Chih-Hui Chiu | N/A |
| Recruiting | Caffeine Optimization Versus Standard Caffeine Dosage (2B-2) NCT05588934 | University of Arizona | N/A |
| Recruiting | Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI NCT06763172 | Hsiao-Ying Wey | Phase 4 |
| Completed | Effects of Caffeine, L-Theanine, and Diaphragmatic Breathing on Esports Players' Performance NCT06621797 | Hacettepe University | N/A |
| Unknown | Consequences of Caffeine Intake in Sleep Restricted Teenagers NCT05790161 | Psychiatric Hospital of the University of Basel | N/A |
| Completed | Caffeine and Hypoxia During Exercise in Males and Females NCT05764018 | Jozef Stefan Institute | N/A |
| Completed | Improving Cognition With Neurodegradation Countermeasure NCT05715073 | University of South Carolina | N/A |
| Completed | A Clinical Trial to Assess the Efficacy of a Plant-based Energy Shot on Focus and ADHD-like Symptoms NCT05857956 | Proper Wild, Inc. | N/A |
| Completed | Effects of Energy Drinks on Sleep and Cardiovascular Health NCT05503732 | Mayo Clinic | N/A |
| Unknown | The Effects of Caffeine on Heart Rate and Heart Rate Variability NCT05521386 | St Mary's University College | N/A |
| Completed | Caffeine Dose: Performance and Recovery NCT07090421 | Ulaç Can YILDIRIM | N/A |
| Completed | Effects of Caffeine on Upper Extremity Performance NCT05916352 | Cyprus International University | N/A |
| Completed | Caffeine Citrate Use and Electronic Activity of the Diaphragm (EDI) Changes NCT05393817 | Seoul St. Mary's Hospital | — |
| Completed | Sleep Deprivation Study NCT05560620 | NeuroCatch Inc. | N/A |
| Completed | Caffeinated Gum Softball Performance NCT06079996 | Chih-Hui Chiu | N/A |
| Active Not Recruiting | Does Caffeine Facilitate Human Reward Learning Behaviors? NCT05325502 | Yu-Shiuan Lin | N/A |
| Recruiting | The Caffeine Therapy in the Fetal to Neonatal Transition NCT05454332 | Hospital de Clinicas de Porto Alegre | Phase 4 |
| Completed | Caffeine Intake Inrelation to Perioperative Analgesic Consumption NCT05330754 | Ain Shams University | — |
| Completed | Consumption Status of Caffeine and Adverse Effects Experience Among Anesthetists NCT05323578 | Ain Shams University | — |
| Completed | Carbohydrate Rinsing and Caffeine Gum on Performance of Romanian Deadlifts Performance NCT05900349 | National Taiwan Sport University | N/A |
| Completed | Caffeine Supplementation, Resistance Training and Blood Antioxidant Status NCT05230303 | The Jerzy Kukuczka Academy of Physical Education in Katowice | N/A |
| Completed | Caffeine Supplementation Improves the Cognitive Abilities and Shooting Performance of Trained E-sports Players NCT05521347 | National Taiwan Sport University | N/A |
| Unknown | Placebo Effects Investigated by Different Experimental Designs NCT04317157 | University of Sao Paulo | N/A |
| Completed | Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.) NCT06195137 | Lu Jiang | N/A |
| Completed | Changes in Metabolic Rate and Perceptual Indicators After Acute Ingestion of Paraxanthine NCT05811923 | Lindenwood University | N/A |
| Completed | Energy Drink Effects on Performance, Mood, and Cardiovascular Outcomes NCT05559372 | Nathaniel Jenkins | N/A |
| Completed | Can Coffee/Caffeine Improve Post-Operative Gastrointestinal Recovery NCT04547868 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Target Weaning Oxygen to Determine Cafffeine Duration for AOP NCT04868565 | Children's Hospital of Chongqing Medical University | Phase 4 |
| Unknown | Pain Management After Shoulder Arthroplasty NCT04872270 | Rothman Institute Orthopaedics | Phase 3 |
| Completed | The Effects of Caffeine on Physical Performance of Ice Hockey Players NCT05170139 | Universidad de Zaragoza | N/A |
| Completed | Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance NCT04712578 | Texas Tech University | N/A |
| Completed | Real-Time Caffeine Optimization During Total Sleep Deprivation NCT04399083 | University of Arizona | N/A |
| Completed | Caffeine and Cerebrovascular Reactivity NCT04730193 | University of Oklahoma | EARLY_Phase 1 |
| Suspended | Effect of Caffeine Supplementation and Personalized Insoles on Females NCT04642131 | Universidad de Zaragoza | N/A |
| Completed | Effect of Caffeine on Myocardial Oxygenation NCT04585854 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Genetics in the Effect of Caffeine on Fat Oxidation NCT05975489 | Universidad Francisco de Vitoria | N/A |
| Completed | Remote Guided Caffeine Reduction NCT04560595 | Johns Hopkins University | N/A |
| Unknown | Associations Between Genetic Markers of Caffeine Metabolism, Appetite Hormones and Body Weight NCT04514588 | Gkouskou Kalliopi | N/A |
| Completed | Acute Caffeine Ingestion on Futsal Performance NCT04852315 | Universidad Francisco de Vitoria | N/A |
| Completed | Neuroplastic Alterations of the Motor Cortex by Caffeine NCT04011670 | University Medical Center Goettingen | N/A |
| Unknown | Direct Effect of Caffeine on Diaphragmatic Muscles NCT04483492 | Hacettepe University | — |
| Completed | Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening NCT04975360 | University of Zurich | N/A |
| Completed | Protocol PERCAF 2018 NCT03859882 | Institut de Recherche Biomedicale des Armees | N/A |
| Completed | Fluids Affecting Bladder Urgency and Lower Urinary Symptoms NCT03625492 | University of Michigan | N/A |
| Completed | The Effects of Iontophoresis in Women With Gynoid Hidrolipodystrophy. NCT03556917 | Universidade Norte do Paraná | Phase 2 / Phase 3 |
| Completed | Effects of Caffeine on Sleep-wake Regulation in Teenagers NCT04321785 | Carolin Reichert | N/A |
| Completed | Acute Effects of Fitness Drink Formulas on Energy Expenditure and Fat Metabolism NCT04455009 | University of Central Florida | N/A |
| Completed | The Effect of Caffeine Ingestion in Prevention of Postoperative Ileus After Caesarean Section. NCT03815877 | Ain Shams University | N/A |
| Completed | Effect of Caffeine on Heart Rate Variability in Newborns NCT04869176 | University of Ljubljana | N/A |
| Unknown | Caffeine for Preterm Infants With Apnea of Prematurity(AOP) NCT03298347 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Completed | Study on Sodium and Caffeine in Children and Adolescents NCT02900261 | University of Lausanne Hospitals | — |
| Completed | The Impact of Caffeine on Cognition in Schizophrenia NCT02832401 | Nova Scotia Health Authority | N/A |
| Completed | Influence of Caffeine Consumption on the Human Circadian System NCT05409339 | Psychiatric Hospital of the University of Basel | N/A |
| Completed | Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive Control NCT02940808 | Leiden University Medical Center | N/A |
| Completed | Effect of Caffeine Intake in Vestibular Function NCT02825199 | Instituto Brasiliense de Otorrinolaringologia | Phase 4 |
| Completed | The Effects of e+Shots Energy Beverage on Mental Energy NCT03850275 | Clarkson University | N/A |
| Completed | Evaluating the Role of Expectations in Response to Caffeine Consumption: An RCT NCT02461693 | University of Alabama at Birmingham | N/A |
| Withdrawn | Metabolic and Genetic Impacts of Energy Drinks in Youth NCT03512496 | University of Calgary | N/A |
| Completed | Effect of Feedings on Caffeine in Premature Infants NCT02293824 | Duke University | — |
| Completed | "The Effects of Caffeine on Overactive Bladder Symptoms and Mental Health in Postmenopausal Women" NCT02180048 | Loma Linda University | N/A |
| Completed | Influence of Caffeine on HRV and Exercise Performance in Spinal Cord Injury NCT02083328 | Swiss Paraplegic Research, Nottwil | N/A |
| Completed | Effects of a Cocoa Shot on the Human Brain 2 NCT02080845 | Wake Forest University Health Sciences | N/A |
| Completed | Early Versus Routine Caffeine Administration in Extremely Preterm Neonates NCT01783561 | Sharp HealthCare | Phase 4 |
| Completed | Effects of a Cocoa Shot on the Human Brain NCT01924481 | Wake Forest University Health Sciences | N/A |
| Completed | Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants NCT01435486 | Hamad Medical Corporation | N/A |
| Completed | Neurophysiological Reserve With Caffeine Manipulation NCT01167478 | University of Sao Paulo | N/A |
| Completed | Effects of Caffeine in Hydration and Energy Metabolism NCT01477294 | Technical University of Lisbon | N/A |
| Completed | Genetic Determinants of Cardiovascular Response to Coffee Drinking NCT01330680 | G. d'Annunzio University | N/A |
| Completed | The Effect of Caffeine on Ischemic Preconditioning NCT00184912 | Radboud University Medical Center | N/A |