NCT05790161

Consequences of Caffeine Intake in Sleep Restricted Teenagers

Consequences of Caffeine Intake in Teenagers: Effects on Sleep, Reward Processing, Risk Taking, and Underlying Cerebral Mechanisms Under Conditions of Sleep Restriction

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 54 (estimated)
• Sponsor: Psychiatric Hospital of the University of Basel · Academic / Other
• Sex: All
• Age: 14 Years – 17 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to systematically investigate two prominent factors in teenagers' daily life: Caffeine and sleep restriction (SR) and their combined influence on sleep, cognition, and behavior in healthy adolescents. The main questions it aims to answer are: The effects of caffeine under conditions of SR and SE: * on sleep pressure and sleep continuity. * on BOLD activity differences in reward related areas during a reward task (monetary incentive delay task) and on reaction times (behavioral aspect) in the same task. * on BOLD activity differences during a risk taking task (wheel of fortune task) and on risky decision-making (behavioral aspect) in the same task. Participants will be either in the SR or SE condition (between-subject). The protocol consists of 2x of approximately one week in which a participant will receive caffeine or placebo (within-subject) at the last two evenings. The experiment consists of an ambulatory and a laboratory phase: * The ambulatory phase consists of 5 nights, including 3 stabilization nights (8h sleep opportunity) prior to 2 nights consisting of either SR with 6h sleep opportunity or SE with 9.5h sleep opportunity. Participants will wear an actiwatch and fill out sleep diaries during this period. * The laboratory phase will be the 6th evening, night and morning of the protocol and will be spent in our lab. Participants will do the following: * treatment (caffeine vs. placebo) intake * saliva sampling * drug screening * cognitive tests, including risk-taking and reward task * filling in questionnaires (sleep diary, sleep quality, sleepiness, mood, expectancy) * waking and sleep with EEG The next day, participants will undergo an fMRI scan, including the following: * resting-state scan * structural scan * arterial spin labeling scan * reward task scan * risk-taking task scan Around the scan, participants will fill out/undergo: * saliva sampling * questionnaires (reward task, mood, sleepiness, expectancy)

Conditions

• Caffeine
• Insufficient Sleep

Interventions

Type	Name	Description
DRUG	Caffeine	2mg/kg, once before night 6 and once before the scan (either on week 1 or 2, alternating with placebo)

Timeline

• Start date: 2023-03-31
• Primary completion: 2024-09-01
• Completion: 2024-09-01
• First posted: 2023-03-30
• Last updated: 2023-05-25

Locations

1 site across 1 country: Switzerland