| Not Yet Recruiting | Ph3b/4 Trial in Patients With Barth Syndrome Barth Syndrome | Phase 4 | 2026-06-30 |
| Active Not Recruiting | ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subje Age Related Macular Degeneration (ARMD) | Phase 3 | 2024-05-30 |
| Completed | Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nucl Mitochondrial Myopathies, Mitochondrial Pathology, Mitochondrial DNA Mutation | Phase 3 | 2022-04-29 |
| Completed | ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-c Age-related Macular Degeneration | Phase 2 | 2019-03-27 |
| Terminated | A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label Primary Mitochondrial Myopathy | Phase 3 | 2017-10-09 |
| Completed | A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome Barth Syndrome | Phase 2 / Phase 3 | 2017-07-05 |
| Completed | An Observational Study of Patients With Primary Mitochondrial Disease (SPIMM-300) Primary Mitochondrial Disease | — | 2017-02-13 |
| Terminated | Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects W Primary Mitochondrial Disease | Phase 2 | 2016-12-01 |
| Completed | An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Age-Related Macular Degeneration | Phase 1 | 2016-10-28 |
| Completed | A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patient Heart Failure | Phase 2 | 2016-10-20 |
| Completed | A Study to Evaluate the Effects of 4 Weeks Treatment With Subcutaneous Elamipretide on Left Ventricular Functi Chronic Heart Failure | Phase 2 | 2016-09-02 |
| Completed | Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Primary Mitochondrial Disease | Phase 2 | 2016-08-22 |
| Completed | Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejectio Heart Failure | Phase 2 | 2016-06-01 |
| Completed | A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for T Leber's Hereditary Optic Neuropathy | Phase 2 | 2016-03-01 |
| Completed | A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for t Fuchs' Corneal Endothelial Dystrophy (FCED) | Phase 1 / Phase 2 | 2016-02-01 |
| Completed | A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 i Normal and Impaired Renal Function | Phase 1 | 2015-05-01 |
| Withdrawn | A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bendavi Heart Failure | Phase 1 | 2015-05-01 |
| Completed | Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy Mitochondrial Myopathy | Phase 1 / Phase 2 | 2015-02-01 |
| Completed | A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly Skeletal Muscle Mitochondrial Dysfunction in the Elderly | Phase 2 | 2015-01-15 |
| Completed | A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Inter Diabetic Macular Edema, Age-related Macular Degeneration | Phase 1 / Phase 2 | 2014-11-01 |
| Completed | A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive He Congestive Heart Failure | Phase 1 | 2014-07-01 |
| Completed | Safety and Pharmacokinetic (PK) Study of Oral Bendavia Administered for 7 Days Healthy Volunteers | Phase 1 | 2013-02-01 |
| Terminated | Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal Artery Renal Artery Obstruction, Hypertension, Renovascular, Ischemia Reperfusion Injury | Phase 1 / Phase 2 | 2012-12-01 |
| Completed | A Phase 1 Study Examining the Pharmacokinetics and Tolerability of a Single Oral Dose of Bendavia (MTP-131) Healthy | Phase 1 | 2012-11-01 |
| Completed | Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Ev Reperfusion Injury, STEMI | Phase 2 | 2012-04-01 |
| Completed | Study to Assess the Pharmacodynamic Effects of Unfractionated Heparin (UFH) in Healthy Volunteers With and Wit Healthy Volunteers | Phase 1 | 2012-01-01 |
| Completed | The Impact of Intravenous Bendavia™ on Endothelial Reactivity Dysfunction in Cigarette Smoking Healthy Volunteers | Phase 1 | 2012-01-01 |
| Completed | Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Ben Healthy | Phase 1 | 2010-05-01 |
| Available | An Intermediate Size Expanded Access Protocol of Elamipretide Mitochondrial Diseases, Barth Syndrome | — | — |