NCT00441597

Does Atorvastatin Reduce Ischemia-Reperfusion Injury in Humans in-Vivo?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.

Detailed description

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (also known as statins) have been found to reduce cardiovascular events. This protective effect has been traditionally explained by lowering plasma cholesterol and subsequent reduced progression of atherosclerosis. However in animal experiments statins have also shown the ability to induce pharmacologic preconditioning and thereby reduce infarct size. This effect contributes to the beneficial effect of statins on reducing of cardiovascular events. In order to differentiate between these two mechanisms of protection we will study the effect of atorvastatin on ischemia reperfusion damage after a short exposure to atorvastatin, before the lipid lowering effect of atorvastatin becomes apparent.

Conditions

• Ischemia Reperfusion Injury
• Cardiovascular Disease

Interventions

Type	Name	Description
DRUG	atorvastatin	atorvastatine 80mg, during 3 days

Timeline

• Start date: 2007-02-01
• Primary completion: 2009-02-01
• Completion: 2009-03-01
• First posted: 2007-03-01
• Last updated: 2009-03-17

Locations

1 site across 1 country: Netherlands