NCT00457652

Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Radboud University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Does caffeine reduce rosuvastatin induced protection against ischemia reperfusion injury?

Detailed description

Rosuvastatin is a proven cholesterol lowering medicine, which hereby is assumed to achieve a reduction in cardiovascular events. Apart from it's cholesterol lowering action, rosuvastatin may also increase tolerance against ischemia-reperfusion injury. In dogs rosuvastatin increases the endogenous concentration of adenosine, by enhancing the activity of the enzyme ecto-5'-nucleotidase, which converts adenosine monophosphate into adenosine. We hypothesize that rosuvastatin increases tolerance against ischemia-reperfusion injury by induction of ecto-5'-nucleotidase and thereby increasing adenosine activity. This protective effect of rosuvastatin can be abrogated by using the adenosine receptor antagonist caffeine.

Conditions

• Ischemia Reperfusion Injury

Interventions

Type	Name	Description
DRUG	Rosuvastatin	7 day treatment rosuvastatin 20mg

Timeline

• Start date: 2007-06-01
• Primary completion: 2007-09-01
• Completion: 2007-11-01
• First posted: 2007-04-06
• Last updated: 2008-04-15

Locations

1 site across 1 country: Netherlands