| Not Yet Recruiting | Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction NCT07429396 | Instituto Politécnico de Leiria | — |
| Recruiting | Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patien NCT07199088 | University of Health Sciences Lahore | N/A |
| Enrolling By Invitation | Chronic Exogenous Ketosis in HFpEF NCT06937320 | Duke University | Phase 2 |
| Enrolling By Invitation | A Preliminary Study for INFORMED NCT05585125 | Weill Medical College of Cornell University | Phase 4 |
| Recruiting | A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRES NCT05887271 | University of Leicester | Phase 2 / Phase 3 |
| Recruiting | Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status NCT06009276 | University of Virginia | — |
| Recruiting | Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction NCT06061549 | Sardocor Corp. | Phase 1 |
| Recruiting | Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure NCT05677100 | Procyrion | N/A |
| Active Not Recruiting | HIDRAdenitis Suppurativa and HEART Disease NCT05989945 | Herlev and Gentofte Hospital | — |
| Completed | External Body Pressure in Heart Failure With Preserved Ejection Fraction NCT05764564 | Duke University | Phase 1 / Phase 2 |
| Recruiting | Pilot Study Lp299v Supplementation in Chronic Heart Failure NCT05752760 | Medical College of Wisconsin | N/A |
| Active Not Recruiting | Cardiac Structure and Function in Patients with Cystic Fibrosis NCT06084468 | Herlev and Gentofte Hospital | — |
| Recruiting | Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction NCT06785506 | Erasmus Medical Center | — |
| Active Not Recruiting | RESPONDER-HF Trial NCT05425459 | Corvia Medical | N/A |
| Completed | Safety and Efficacy Study of AI LVEF NCT05140642 | Cedars-Sinai Medical Center | N/A |
| Recruiting | Value of Intense Phenotyping in Heart Failure With Preserved Ejection Fraction NCT05479669 | University Medical Center Groningen | — |
| Completed | Exercise Training in Heart Failure With Preserved Ejection Fraction - a Long-term Follow-up NCT05162859 | Technical University of Munich | — |
| Unknown | The Effect of Different Low-Level Tragus Stimulation Parameters On Autonomic Nervous System Function NCT04682704 | University of Oklahoma | N/A |
| Completed | Impact of Empagliflozin on Functional Capacity in Heart Failure with Preserved Ejection Fraction NCT05139472 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Me NCT05475028 | University of Campania Luigi Vanvitelli | — |
| Recruiting | Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis NCT04950218 | Herlev and Gentofte Hospital | — |
| Unknown | sPERMIdine supplemenTation on Metabolic, Neuronal and Cardiovascular Response to Exercise TRAINING NCT05128331 | University Medicine Greifswald | N/A |
| Unknown | Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Stra NCT05638230 | Yonsei University | — |
| Recruiting | Assessment of Left Ventricular Filling Pressure by Applying Artificial Intelligence Algorithms to Left Atrial NCT05768698 | Istituto Auxologico Italiano | — |
| Completed | Cardiac Magnetic Resonance Tomography for Heart Failure With Preserved Ejection Fraction NCT05322109 | German Heart Institute | — |
| Completed | Impact of Beta-blockers on Physical Function in HFpEF NCT04767061 | Weill Medical College of Cornell University | Phase 4 |
| Completed | Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF NCT04757584 | Weill Medical College of Cornell University | Phase 4 |
| Completed | Physiologic Accelerated Pacing as a Treatment in Patients With Heart Failure With Preserved Ejection Fraction NCT04546555 | Daniel L Lustgarten | N/A |
| Completed | The Aortix CRS Pilot Study NCT04145635 | Procyrion | N/A |
| Active Not Recruiting | The Relationship Between Inflammatory ARTritis and CArdiac DIseAse NCT05647577 | University Hospital, Gentofte, Copenhagen | — |
| Unknown | Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure NCT05008692 | University Health Network, Toronto | — |
| Completed | MyoMobile Study: App-based Activity Coaching in Patients with Heart Failure and Preserved Ejection Fraction NCT04940312 | Johannes Gutenberg University Mainz | — |
| Recruiting | Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging NCT04602338 | Chinese Academy of Medical Sciences, Fuwai Hospital | — |
| Recruiting | Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF NCT05577819 | Massachusetts General Hospital | N/A |
| Unknown | Personalized Atrial Septostomy for Heart Failure NCT04573166 | China National Center for Cardiovascular Diseases | N/A |
| Completed | Exercise Pulmonary Transit Time NCT04336995 | Vanderbilt University Medical Center | Phase 4 |
| Completed | Physiological Signals, Activity and Posture for Surface Mounted Insertable Cardiac Monitor in Heart Failure St NCT04112576 | Boston Scientific Corporation | — |
| Unknown | Stratified Treatment to Ameliorate Diastolic Left Ventricular Stiffness in Heart Failure With Preserved Ejecti NCT04475042 | Mariëlle Scheffer | Phase 2 |
| Completed | Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program NCT04281849 | VA Eastern Colorado Health Care System | N/A |
| Terminated | Evaluating Metabolic Mechanisms of Ertugliflozin in Diabetes & Heart Failure NCT04071626 | University Hospitals Cleveland Medical Center | Phase 4 |
| Unknown | Mechanisms of Right Ventricular Adaptation in Patients With Heart Failure With Preserved Ejection Fraction NCT04154657 | Johann Wolfgang Goethe University Hospital | N/A |
| Unknown | HbA1c as an Early Serologic Marker for the Hemodynamic Progression of Stage A Heart Failure NCT04450576 | Parkview Medical Center | — |
| Active Not Recruiting | AB-1002 in Patients With Class III Heart Failure NCT04179643 | AskBio Inc | Phase 1 |
| Active Not Recruiting | Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction NCT04068844 | University of Texas Southwestern Medical Center | N/A |
| Completed | Effects of Empagliflozin on Exercise Capacity and Left Ventricular Diastolic Function in Patients With Heart F NCT03753087 | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | Phase 4 |
| Recruiting | Multimodality Imaging in the Screening, Diagnosis and Risk StratifictiON of HFpEF NCT04603404 | Chinese Academy of Medical Sciences, Fuwai Hospital | — |
| Completed | Respiratory Muscle Function in Heart Failure NCT03924479 | Mayo Clinic | N/A |
| Unknown | Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Fail NCT03830957 | Rajaie Cardiovascular Medical and Research Center | N/A |
| Completed | CCM in Heart Failure With Preserved Ejection Fraction NCT03240237 | Impulse Dynamics | N/A |
| Completed | Hemodynamic-GUIDEd Management of Heart Failure NCT03387813 | Abbott Medical Devices | N/A |
| Completed | CoQ10 and D-ribose in Patients With Diastolic Heart Failure NCT03133793 | University of Kansas Medical Center | Phase 2 |
| Terminated | Muscle, Essential Amino Acids, and eXercise in Heart Failure NCT03312387 | Arizona State University | N/A |
| Completed | Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs NCT02941705 | Cedars-Sinai Medical Center | Phase 2 |
| Completed | Implementation of Telerehabilitation In Support of HOme-based Physical Exercise for Heart Failure NCT03183323 | Helse Nord-Trøndelag HF | N/A |
| Completed | Mechanisms and Management of Exercise Intolerance in Older Heart Failure Patients NCT03111017 | The University of Texas at Arlington | N/A |
| Completed | Feasibility Study of a New Peripheral Oedema Monitor for Heart Failure NCT02993601 | Heartfelt Technologies | — |
| Completed | Noninvasive Neuromodulation to Reserve Diastolic Dysfunction NCT02983448 | University of Oklahoma | N/A |
| Terminated | Novel Cardiac Rehabilitation in Patients Heart Failure and Preserved Ejection Fraction NCT02762825 | Henry Ford Health System | N/A |
| Completed | Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF NCT02589977 | Marvin W. Kronenberg, M.D. | Phase 4 |
| Completed | Exercise Intolerance in Elderly Patients With HFpEF(Heart Failure With Preserved Ejection Fraction) NCT02636439 | Wake Forest University Health Sciences | N/A |
| Completed | Weight Loss as Therapy for Heart Failure With Preserved Ejection Fraction NCT02911337 | Medical University of South Carolina | N/A |
| Completed | Improving Metabolic Health in Patients With Diastolic Dysfunction NCT03448185 | University of Texas Southwestern Medical Center | N/A |
| Completed | Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease NCT03476785 | University of Texas Southwestern Medical Center | N/A |
| Completed | PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study) Stockholm Heart Failure Study NCT03671122 | Karolinska Institutet | — |
| Completed | Kyoto Congestive Heart Failure Study NCT02334891 | Kyoto University, Graduate School of Medicine | — |
| Unknown | Optimized Management of Comorbidity in Heart Failure With Preserved Ejection Fraction in the Elderly (>60 Year NCT02425371 | Göteborg University | Phase 3 |
| Withdrawn | Exercise Training in Treating Diastolic Heart Failure NCT02155842 | Norwegian University of Science and Technology | N/A |
| Completed | Efficacy Study of Pacemakers to Treat Slow Heart Rate in Patients With Heart Failure NCT02145351 | Mayo Clinic | N/A |
| Unknown | Renal Denervation in Patients With Heart Failure With Normal LV Ejection Fraction NCT02115230 | InCor Heart Institute | N/A |
| Completed | Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support. NCT02408003 | Sahlgrenska University Hospital | N/A |
| Completed | Diuretics and Dopamine in Heart Failure With Preserved Ejection Fraction NCT01901809 | Johns Hopkins University | Phase 4 |
| Unknown | Assessment of Functional Capacity and Inflammatory Markers in Women With Heart Failure With Preserved Ejection NCT02649400 | Federal University of São Paulo | — |
| Completed | Autologous Bone Marrow Mononuclear Cells in the Combined Treatment of Coronary Heart Disease NCT02059512 | St. Petersburg State Pavlov Medical University | N/A |
| Completed | Atrial Fibrillation Ablation NCT03410966 | University of Campania Luigi Vanvitelli | N/A |
| Completed | Yôga and Breathing Techniques Training in Patients With Heart Failure and Preserved Ejection Fraction NCT03028168 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Inhaled Nitrite in Subjects With Pulmonary Hypertension NCT01431313 | Schmidhofer, Mark, MD | Phase 2 |
| Completed | Predicting Heart Failure Outcomes With Biomarkers and Imaging NCT07332520 | Xinjiang Medical University | — |
| Completed | Sildenafil in HFpEF (Heart Failure With Preserved Ejection Fraction) and PH NCT01726049 | University Medical Center Groningen | Phase 3 |
| Completed | Radiofrequency-based Speckle Tracking Echocardiography to Evaluate Diastolic Function NCT01182805 | University of Michigan | Phase 1 / Phase 2 |
| Completed | SIDAMI - Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (AMI) NCT01046838 | Jacob E Mueller | Phase 4 |
| Completed | Prognostic Impact of Noncardiac Comorbidities in Heart Failure Patients NCT02946476 | Ospedale Maggiore Di Trieste | — |
| Terminated | Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure NCT00799435 | Baylor College of Medicine | Phase 4 |
| Completed | Exercise Intolerance in Elderly Patients With Diastolic Heart Failure NCT00959660 | Wake Forest University | N/A |
| Completed | Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension NCT00820352 | University Teaching Hospital Hall in Tirol | Phase 3 |
| Unknown | Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction NCT00628082 | University Hospital Birmingham | — |