NCT05638230

Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 2,500 (estimated)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to learn about left atrial reservoir strain in patients with heart failure with preserved ejection fraction. The main questions it aims to answer are: * Usefullness of LARS as a predictor of high HFA-PEFF diagnostic algorithm scores (≥5) * The relative importance of LARS in variables including each component of HFA-PEFF and traditional cardiovascular risk factors.

Conditions

• Heart Failure, Diastolic
• Heart Failure, Preserved Ejection Fraction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Left atrial reservoir strain	LA strain measurements can be obtained by two dimensional (2D) speckle tracking echocardiography (STE). Longitudinal strain and strain rate curves are generated for each of six atrial segments, obtained from the apical four and two chamber views. In the reservoir phase, as the LA fills and stretches, there is positive atrial strain that reaches its peak in systole at the end of LA filling, prior to opening of the mitral valve. Following this, passive LA emptying ensues with opening of the mitral valve resulting in decreased atrial strain with negative deflection of the strain curve up to a plateau period which is analogous to diastasis. LA reservoir strain (LARS), or peak atrial longitudinal strain or LA systolic strain, is measured at the end of the reservoir phase.

Timeline

• Start date: 2021-08-01
• Primary completion: 2023-07-31
• Completion: 2025-07-31
• First posted: 2022-12-06
• Last updated: 2022-12-06

Locations

1 site across 1 country: South Korea