| Not Yet Recruiting | A Cross-sectional Study on the Impact of Shift Work on Diastolic Dysfunction in Healthcare Workers NCT07331233 | National Taiwan University Hospital | — |
| Recruiting | Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension NCT07480265 | Necmettin Erbakan University | — |
| Not Yet Recruiting | Effect of Swimming Exercise on Diastolic Dysfunction NCT06945913 | Uşak University | N/A |
| Recruiting | AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction NCT06580158 | Mayo Clinic | — |
| Unknown | Timely Recovery After Subclinical Heart Failure NCT06341101 | Academisch Ziekenhuis Maastricht | Phase 4 |
| Active Not Recruiting | Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography NCT06200519 | University College Cork | — |
| Active Not Recruiting | Polyamine Treatment in Elderly Patients With Coronary Artery Disease NCT06186102 | University of Aarhus | Phase 2 |
| Completed | Tumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes Mellitus NCT06129448 | Sirnak State Hospital | — |
| Unknown | Diastology-Guided Management of Decompensated Heart Failure NCT06131008 | McMaster University | N/A |
| Unknown | The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection NCT05847244 | Sara ElAdawy | Phase 2 |
| Active Not Recruiting | Effect of Intradialytic Exercise on Left Ventricular Diastolic Function in Hemodialysis Patients NCT06584734 | Instituto Nacional de Cardiologia Ignacio Chavez | N/A |
| Unknown | Diastolic Function in Myotonic Dystrophy Type 1 NCT06029192 | Centre d'Investigation Clinique et Technologique 805 | — |
| Unknown | Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Moni NCT05745337 | University of Vermont | Phase 1 |
| Completed | Diastolic Dysfunction in Septic Shock and Cardiomyopathy Genetic Variants NCT05552521 | Hospital Garcia de Orta | — |
| Unknown | Diastolic Function Assessment With Cardiac Magnetic Resonance Imaging NCT05438030 | Imperial College London | N/A |
| Recruiting | Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES NCT05408559 | Texas Tech University Health Sciences Center | Phase 1 / Phase 2 |
| Unknown | Diagnostics of Coronavirus Disease 2019 Cardiovascular Complications NCT05608603 | I.M. Sechenov First Moscow State Medical University | — |
| Unknown | Sex Related Differences in Cardiac Function NCT05796050 | Heinrich-Heine University, Duesseldorf | — |
| Terminated | Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors NCT05699915 | Algemeen Ziekenhuis Maria Middelares | N/A |
| Completed | Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection. NCT05379608 | I.M. Sechenov First Moscow State Medical University | N/A |
| Active Not Recruiting | MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women NCT03586414 | University of Colorado, Denver | N/A |
| Unknown | Diastolic dYsfunctioN AssessMent in critICally Ill Patients NCT04584203 | Humanitas Clinical and Research Center | — |
| Completed | Bisoprolol Administration to Prevent Anthracycline-induced Cardiotoxicity NCT05175066 | Shahid Beheshti University of Medical Sciences | Phase 3 |
| Recruiting | Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN) NCT04558450 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Danish National Randomized Study on Early Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic NCT03972644 | Odense University Hospital | N/A |
| Unknown | Effects of Remifentanil on Cardiac Function in Patients With Diastolic Dysfunction NCT04117009 | Yeditepe University | Phase 4 |
| Withdrawn | Diastolic Dysfunction PPCM in Patients With Documented Left Ventricular Systolic Function Recovery NCT04143997 | Medical College of Wisconsin | — |
| Completed | Diastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric Surgery NCT04128735 | Mahidol University | — |
| Completed | Personalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ej NCT04721314 | University of Vermont | N/A |
| Unknown | Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary Heart Di NCT03887013 | China National Center for Cardiovascular Diseases | Phase 4 |
| Completed | Effect of Diastolic Dysfunction on Dynamic Cardiac Monitors NCT04177225 | University of California, Davis | — |
| Terminated | The MyoVista Angiography Angioplasty Percutaneous Coronary Intervention Trial NCT03635801 | Royal Cornwall Hospitals Trust | — |
| Completed | Ciprofibrate and Pre-diabetes NCT03662984 | Maastricht University Medical Center | Phase 3 |
| Terminated | Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI NCT04149990 | Jacob Moller | Phase 2 |
| Completed | Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients NCT03768752 | Universitätsklinikum Hamburg-Eppendorf | — |
| Unknown | The Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension Stu NCT04190420 | Karolinska Institutet | — |
| Completed | Heart Failure and Hemodynamic Stability During Anesthesia Induction NCT03576261 | Umeå University | N/A |
| Completed | Assessment of Diastolic Function in High Risk Patients Undergoing Major Vascular Surgery NCT03534440 | Medical University of Warsaw | — |
| Completed | Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis NCT03249532 | Amsterdam UMC, location VUmc | N/A |
| Completed | PDD in Type 2 Diabetes w/wo Diastolic Dysfunction NCT03744975 | Mayo Clinic | Phase 2 |
| Unknown | Reversibility of Diastolic Disfunction in Septic Shock NCT03198611 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Unknown | REWARD: Using the REtina as a Window To Detect Cardiac microvasculAR Dysfunction In Diabetes Mellitus NCT04025996 | National Heart Centre Singapore | — |
| Completed | Prevalence of Hypovolemia and Heart Failure in Non-cardiac Surgery NCT03349593 | Umeå University | — |
| Completed | Pre-operative Focused Transthoracic Echocardiography for Prediction of Post-operative Cardiac Complications NCT04114474 | South Egypt Cancer Institute | — |
| Unknown | Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients NCT03177408 | Jing Li | — |
| Unknown | Frequency of Asymptomatic Left Ventricular Diastolic Dysfunction in Diabetes Mellitus Type 2 NCT03196687 | Assiut University | — |
| Unknown | Bubbles, Stress, Diastole NCT03210012 | Clinica ARS Medica | — |
| Completed | Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock NCT02918214 | University Hospital, Limoges | — |
| Completed | Characterizing HIV-related Diastolic Dysfunction NCT02860156 | Duke University | — |
| Completed | Effects of Empagliflozin on Left Ventricular Diastolic Function Compared to Usual Care in Type 2 Diabetics NCT02932436 | Johannes Gutenberg University Mainz | Phase 4 |
| Completed | Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects NCT02874703 | Massachusetts General Hospital | — |
| Completed | Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function NCT05058833 | Samsung Medical Center | — |
| Completed | Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients NCT02655770 | Rigshospitalet, Denmark | Phase 4 |
| Completed | Ghrelin and Diastolic Heart Function NCT05988346 | University of Campania Luigi Vanvitelli | — |
| Completed | Aerobic Versus Combined Exercise and Diastolic Dysfunction NCT04916184 | Evangelismos Hospital | N/A |
| Unknown | CORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD) NCT02499601 | CorAssist Cadiovascular Ltd. | N/A |
| Completed | Analysis of Incidence and Risk Factors of Severe Cardiovascular Events in Patients With Diastolic Dysfunction NCT03138109 | Yan Zhou, MD | — |
| Completed | Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian Descent NCT02660047 | Leiden University Medical Center | Phase 4 |
| Completed | Screening of Diastolic Dysfunction With Impedance Cardiography in Hypertensive Patients NCT03209141 | Centro Hospitalar de Lisboa Central | — |
| Unknown | Perioperative Measurements of Diastolic Function in Cardiac Surgery NCT02285309 | University College, London | — |
| Completed | Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity an NCT02294292 | Institute of Liver and Biliary Sciences, India | N/A |
| Completed | Metformin in the Diastolic Dysfunction of Metabolic Syndrome NCT02017561 | Universidade do Porto | Phase 2 |
| Completed | Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPD NCT03110614 | University of Alabama at Birmingham | — |
| Completed | Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients NCT01761318 | Leiden University Medical Center | Phase 4 |
| Completed | Effect of Dietary Sodium Restriction in the Management of Patients With Heart Failure and Diastolic Dysfunctio NCT01896908 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Targeting Inflammation to Treat Cardiovascular Aging NCT01775865 | Gary L. Pierce | Phase 2 |
| Unknown | Relation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes. NCT02689570 | University Hospital, Antwerp | — |
| Terminated | The Effect of Heart Rate on Cardiac Index in Patients With Left Ventricular Hypertrophy NCT01241838 | University of Aarhus | N/A |
| Terminated | Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular Hypertrophy NCT01188369 | University of Aarhus | Phase 4 |
| Terminated | A Trial of Intravenous Calcium and Myocardial Diastolic Dysfunction During Separation From Cardiopulmonary Byp NCT00955266 | Brigham and Women's Hospital | Phase 4 |
| Terminated | Effects of Pycnogenol on Cardiac Fibrosis and Diastolic Dysfunction in Aged Hypertensive Subjects NCT00952627 | University of Arizona | Phase 2 |
| Enrolling By Invitation | Disease Prevention in Clinical Practice Base on Patient Specific Physiology NCT03308773 | Pacific Coast Family Medical Group | — |
| Completed | Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Inde NCT00907439 | Washington University School of Medicine | — |
| Completed | Effect of Exercise on Heart Function in Healthy Elderly People NCT00804518 | Norwegian University of Science and Technology | N/A |
| Completed | Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients NCT00689819 | Wayne State University | N/A |
| Terminated | Weight Loss in Pre-Hypertensive Patients With Diastolic Dysfunction NCT00911209 | Ragavendra Baliga | N/A |
| Completed | Early Diagnosis of Diastolic Dysfunction and Reliability of DSE in Detecting Stress Diastolic Dysfunction NCT00998205 | University of Missouri-Columbia | N/A |
| Completed | Early Detection of Diastolic Dysfunction and the Role of Lifestyle Measures in Its Treatment NCT00998114 | University of Missouri-Columbia | N/A |
| Unknown | Clinical Observational Study Investigating the Role of Diastolic Dysfunction in Determining Abnormal Cardiores NCT00765349 | Newcastle-upon-Tyne Hospitals NHS Trust | — |
| Completed | The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients NCT00523549 | Novartis Pharmaceuticals | Phase 4 |
| Completed | Simvastatin and Diastolic Dysfunction NCT01061450 | Brasilia Heart Study Group | Phase 4 |
| Unknown | Markers of Oxidative Stress Diastolic Dysfunction NCT00846404 | Emory University | — |
| Completed | To Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of th NCT00170924 | Novartis | Phase 4 |