NCT03576261

Heart Failure and Hemodynamic Stability During Anesthesia Induction

Does Heart Failure Has Impact on Hemodynamic Stability During Anesthesia Induction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Umeå University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aim is to investigate whether preoperative heart failure has impact on hemodynamic stability during anesthesia induction by target controlled infusion of anesthesia (TCI) in non-cardiac, non-morbidly obese surgery.

Detailed description

40 individuals are enrolled to the study after signed informed consent at the day of surgery. The study participants are randomized (non-blinded) to preoperative fluid therapy (preoperative colloid fluid bolus at 6 ml/kg LBW, Gelofusine™, Fresenius Kabi AB, Sweden) or control (no preoperative fluids) before standardized TCI- induction of anesthesia. No other intravenous fluids before anesthesia induction. Preoperative screening of biventricular systolic and diastolic function of the heart and level of venous return is implemented by transthoracic echocardiography approximately one hour before preoperative fluid therapy and anesthesia induction.

Conditions

• Hemodynamic Instability
• Anesthesia; Adverse Effect
• Heart Failure
• Diastolic Dysfunction
• Venous; Return (Anomaly)

Interventions

Type	Name	Description
OTHER	Preoperative colloid fluid bolus (Gelofusine)	Preoperative colloid fluid bolus
DIAGNOSTIC_TEST	Preoperative transthoracic echocardiography	Screening of biventricular systolic and diastolic function of the heart and level of venous return by transthoracic echocardiography approximately one hour before preoperative fluid therapy and anesthesia induction.

Timeline

• Start date: 2018-08-01
• Primary completion: 2021-12-01
• Completion: 2021-12-02
• First posted: 2018-07-03
• Last updated: 2021-12-16

Locations

1 site across 1 country: Sweden