NCT04916184

Aerobic Versus Combined Exercise and Diastolic Dysfunction

Effects of Exercise Training on Diastolic and Systolic Dysfunction in Patients With Chronic Heart Failure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Evangelismos Hospital · Academic / Other
• Sex: All
• Age: 36 Years – 71 Years
• Healthy volunteers: Not accepted

Summary

Thirty-two stable patients with chronic heart failure participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM). Before and after the program, they underwent a symptom-limited maximal cardiopulmonary exercise testing and serial echocardiography evaluation examining the indices of diastolic dysfunction (DD).

Detailed description

Thirty-two stable patients with chronic heart failure (age: 56 ± 10 years, EF: 32 ± 8%, 88 % men) participated in an exercise rehabilitation program. They randomly assigned to aerobic exercise (AER) or combined aerobic and strength training (COM), based on age and peak oxygen uptake, as stratified randomization criteria. Before and after the program, they underwent a symptom-limited maximal cardiopulmonary exercise testing (CPET) and serial echocardiography assessment to evaluate peak oxygen uptake (VO2peak), peak workload (Wpeak), DD grade, right ventricular systolic pressure (RVSP) and EF.

Conditions

• Diastolic Dysfunction
• Heart Failure

Interventions

Type	Name	Description
OTHER	aerobic exercise	exercise training rehabilitation (aerobic exercise with/without strength training)
OTHER	combined exercise	exercise training rehabilitation (aerobic exercise with/without strength training)

Timeline

• Start date: 2016-01-01
• Primary completion: 2020-12-31
• Completion: 2021-02-01
• First posted: 2021-06-07
• Last updated: 2021-06-07

Locations

1 site across 1 country: Greece