NCT05988346

Ghrelin and Diastolic Heart Function

Ghrelin Expression Could Regulate Diastolic Heart Function in Obese Patients With Diabetes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: University of Campania Luigi Vanvitelli · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastolic function (LV-DF). Ghrelin could modulate these pathways. Thus, in the current study authors will investigate ghrelin expression in T2DM obese patients after abdominal fat excision, and particularly in those with normalization of LV-DF at 1 year of follow-up.

Conditions

• Diabetes Mellitus, Type 2
• Obesity, Abdominal
• Diastolic Dysfunction

Interventions

Type	Name	Description
PROCEDURE	abdominal plastic intervention	According to international guidelines, authors will remove the superficial abdominal fat from the patients enrolled in the study.

Timeline

• Start date: 2016-01-01
• Primary completion: 2022-01-01
• Completion: 2022-03-01
• First posted: 2023-08-14
• Last updated: 2023-08-24

Locations

1 site across 1 country: Italy