NCT03586414

MitoQ Supplementation and Cardiovascular Function in Healthy Men and Women

Mitochondrial Targeted Antioxidant Supplementation and Diastolic Function in Healthy Men and Women

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: All
• Age: 50 Years – 75 Years
• Healthy volunteers: Accepted

Summary

In this pilot study, the investigators will determine whether supplementation with a mitochondrial-targeted antioxidant (Mitoquinone (MitoQ)) improves mitochondrial function, left ventricular diastolic and vascular function.

Detailed description

Heart failure affects over 5 million American adults and the risk of heart failure increases with age. Diastolic function typically declines with age. Targeting age-related causal factors leading to the decline in diastolic function in both women and men is a major public health initiative. In this pilot study, the investigators will determine whether supplementation with a mitochondrial-targeted antioxidant (Mitoquinone (MitoQ)) improves mitochondrial function, left ventricular diastolic and vascular function in older adults. As an exploratory aim, the investigators will determine whether there are differences between men and women in response to this supplementation.

Conditions

• Diastolic Dysfunction

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	MITOQUINOL MESYLATE then placebo	MITOQUINOL MESYLATE then placebo: 'MITOQUINOL MESYLATE' administered twice daily for 4 weeks followed by a washout, then placebo capsule administered twice daily for 4 weeks. Capsules with active product contain 20 mg of 'MITOQUINOL MESYLATE'.
DIETARY_SUPPLEMENT	Placebo, then MITOQUINOL MESYLATE	'Placebo, then MITOQUINOL MESYLATE' : Placebo administered twice daily for 4 weeks followed by a washout, then 'MITOQUINOL MESYLATE' capsule administered twice daily for 4 weeks. Capsules with active product contain 20 mg of 'MITOQUINOL MESYLATE'.

Timeline

• Start date: 2021-08-01
• Primary completion: 2030-07-01
• Completion: 2030-08-01
• First posted: 2018-07-13
• Last updated: 2025-03-07

Locations

1 site across 1 country: United States